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Carlos Fernández-del Castillo, M.D.
Division of General Surgery
15 Parkman Street, WANG (WACC) 460
Boston, MA 02114
cfernandez@partners.org
Phone: (617) 726-5644
Fax: (617) 724-3383

Clinical Background:

MD Degree:
National Autonomous University of Mexico, Mexico City

Residency:
Chief Resident in Surgery Instituto Nacional de la Nutricion, Mexico City

Fellowship:
Research fellow in Surgery, Harvard Medical School, Boston, Massachusetts

Board of Certifications:
Mexican Board of Surgery

Clinical Interests:
Pancreatic Diseases, Pancreatobiliary Surgery, Gastrointestinal Surgery

Professional Societies:
American College of Surgery
Society for Surgery of the Alimentary Tract
Society of Surgical Oncology
American Pancreatic Association
Society of University Surgeons

Recent Publications:

1. Salvia R, Fernández-del Castillo C, Bassi C, Thayer SP, Falconi M, Mantovani W, Pederzoli P, Warshaw AL. Main-duct intraductal papillary mucinous neoplasms of the pancreas: Clinical predictors of malignancy and long-term survival following resection. Annals of Surgery 2004; 239:679-687.

1. Brugge, WR, Lewandrowski K, Lee-Lewandrowski E, Centeno BA, Szydlo T, Regan S, Fernández-del Castillo C, Warshaw AL, and the Investigators of the CPC study. Diagnosis of pancreatic cystic neoplasms: a report of the cooperative pancreatic cyst study. Gastroenterology 2004; 126:1330-1336.

2. Deshpande V, Fernández-del Castillo C, Muzikansky A, Deshpande A, Zucerberg L, Warshaw AL, Lauwers GY. Cytokeratin 19 is a powerful predictor of survival in pancreatic endocrine neoplasms. Am J Surg Pathol 2004 (in press).

3. Deshpande V, Selig MK, Nielsen GP, Fernandez-del Castillo C, Lauwers GY. Ductulo-insular pancreatic endocrine neoplasms: clinicopathologic analysis of a unique subtype of pancreatic endocrine neoplasms. Am J Surg Pathol 2003; 27:461-8.

4. KernBE, Balcom JH, Antoniu BA,Warshaw AL, Fernández-del Castillo C. Troponin I Peptide (Glu94-Leu123), a cartilage-derived angiogenesis inhibitor: in vitro and in-vivo effects on human endothelial cells and on pancreatic cancer. Journal of Gastrointestinal Surgery 2003; 7:961-969.

5. Thayer SP, Pasca di Magliano M. Heiser PW, Nielsen CM, Roberts DJ, Lauwers GY, Qi YP, Gysin S,m Fernández-del Castillo C, Yajnik V, Antoniu B, McMahon M, Warshaw AL, Hebrok M. Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis. Nature 2003; 425:851-856.

6. Fernández-del Castillo C, Targarona J, Thayer SP, Rattner DW, Brugge WR, Warshaw AL: Incidental Pancreatic Cysts: Clinicopathologic Characteristics and Comparison with Symptomatic Patients. Archives of Surgery 2003; 138: 427-434.

7. Keck T, Balcom J, Fernández-del Castillo C, Antoniu B, Warshaw AL. Matrix Metalloproteinase-9 Promotes Neutrophil Migration and Alveolar Capillary Leakage in Pancreatitis-associated Lung Injury in the Rat. Gastroenterology 2002; 122:188-201.

8. Balcom J, Keck T, Warshaw AL, Graeme Cook F, Fernández-del Castillo C. Prevention of Pancreatic Fistula with a New Synthetic, Absorbable Sealant: Evaluation in a Dog Model. J of American College of Surgeons 2002; 195:490-296.

Werner J, Mouris S, Warshaw AL, Lewandrowski K, Laposata M, Iozzo R, Carter E, Schatz, Fernández-del Castillo C. Alcoholic pancreatitis in rats: injury nonoxidative metabolites of ethanol. Am J Physiol (Gastrointest Liver Physio) 2002; 283:G65-73.