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Publications


Selected peer-reviewed publications
  1. Vora, A., Fitzgerald, M. and Grandgenett, D.(1990). Removal of 3'-OH-terminal nucleotidesfrom blunt-ended long terminal repeat termini by the avian retrovirus integration protein. J. of Virol., 64, 5656-5659 PMID: 2214031

  2. Fitzgerald, M., Vora, A. and Grandgenett, D. (1991). Development of an acid-soluble assay for measuring retrovirus integrase 3'-OH terminal nuclease activity.  Anal. Biochem., 196, 19-23. PMID: 1888032

  3. Fitzgerald, M., Vora, A., Zeh, B. and Grandgenett, D. (1992). Concerted integration of viral DNA termini by purified avian myeloblastosis virus integrase.  J. of Virol., 66, 6257-6263 PMID: 1328665

  4. Grandgenett, D., Inman, R., Vora, A. and Fitzgerald, M. (1993). Comparison of DNA binding and integration half-site selection by avian myeloblastosis virus integrase. J. of Virol., 67, 2628-2636 PMID: 8474165

  5. Fitzgerald, M. and Grandgenett, D. (1994). Retroviral integration: in vitro host site selection by avian myeloblastosis virus integrase. J. of Virol., 68, 4314-4321 PMID: 8207806

  6. Vora, A., McCord, M.,Fitzgerald, M., Inman, R., Grandgenett, D. (1994) Efficient concerted integration of retrovirus-like DNA in vitro by avian myeloblastosis virus integrase. Nucleic Acids Res., 22, 4454-4461 PMID: 7971276

  7. Reed, GL., Houng, A.,Fitzgerald, ML. (1999) Platelet secretory protein, a human unc-18c homologue that interacts with syntaxin 4 and is phosphorylated in activated cells: implication for triggered secretion in platelets. Blood, 93:2617-2626 PMID: 10194441

  8. Fitzgerald, ML and Reed, GL. (1999) Rab6 is phosphorylated in thrombin-activated platelets by a protein kinase C-dependent mechanism: effects on GTP/GDP binding and cellular distribution. Biochemical Journal 342:353-360 PMID: 10455022

  9. Fitzgerald, ML, Moore, KJ, Freeman, M., and Reed, GL. (2000) Lipopolysaccharide induces Scavenger Receptor-A expression in mouse macrophages: a divergent regulatory mechanism relative to human macrophages. J. of Immunology 164(5):2692-700 PMID: 10679110

  10. Moore KJ, Rosen ED, Fitzgerald ML, Randow F, Andersson LP, Altshuler D, Milstone DSPP, Mortensen RM, Spiegelman BM, Freeman, MW (2001) The role of PPAR-gamma in macrophage differentiation and cholesterol uptake.  Nature Medicine 2001 Jan;7(1):41-7 PMID: 11135614

  11. Fitzgerald ML, Mendez AJ, Moore KJ, Andersson LP, Panjeton HA, and MW Freeman. (2001) ABCA1 contains an N-terminal signal-anchor sequence that translocates the protein’s first hydrophilic domain to the exoplasmic space J. of Biol. Chem. 276: 15137-15145 PMID: 11328826

  12. Fitzgerald ML, Morris AL, Rhee JS, Andersson LP, MendezAJ, Freeman MW. Naturally Occurring Mutations in the Largest Extracellular Loops of ABCA1 Can Disrupt Its Direct Interaction with Apolipoprotein A-I. J Biol Chem 2002 Sep 6;277(36):33178-87 PMID: 12084722

  13. Fukumoto H, Deng A, Irizarry MC, Fitzgerald ML, Rebeck GW. Induction of the cholesterol transporter ABCA1 in central nervous system cells by liver X receptor agonists increases secreted Abeta levels. J Biol Chem. 2002 Dec 13;277(50):48508-13. PMID: 12384498

  14. Fitzgerald ML, Morris AL, Chorni A, Mendez AJ, Zannis VI, Freeman MW. ABCA1 and amphipathic apolipoproteins form high affinity molecular complexes required for cholesterol efflux. J. of Lipid Research, 2004 Feb;45(2):287-94. Epub 2003 PMID: 14617740

  15. Chroni A, Liu T, Fitzgerald ML, Freeman MW, Zannis VI. Cross-Linking and Lipid Efflux Properties of APOA-I Mutants Suggest Direct Association between APOA-I Helices and ABCA1. Biochemistry (2004) Feb 24;43(7):2126-39. PMID: 14967052

  16. Nieland TJ, Chroni A, Fitzgerald ML, Maliga Z, Zannis VI, Kirchhausen T, Krieger M. Cross-inhibition of SR-BI- and ABCA1-mediated cholesterol transport by the small molecules BLT-4 and glyburide. J Lipid Res. 2004 Jul;45(7):1256-65. Epub 2004 Apr 21 PMID: 15102890

  17. Fitzgerald ML, Okuhira KI, Short GF 3rd, Manning JJ, Bell SA, Freeman M. ABCA1 contains a novel C-terminal VFVNFA motif that is required for its cholesterol efflux and apoA-I binding activities. J Biol Chem. 2004 279:48477-485 PMID: 15347662

  18. Fukuchi J, Hiipakka RA, Kokontis JM, Hsu S, Ko AL, Fitzgerald ML, Liao S. Androgenic suppression of ATP-binding cassette transporter A1 expression in LNCaP human prostate cancer cells. Cancer Res. 2004 Nov 1;64(21):7682-5. PMID: 15520169

  19. Kim WS*, Fitzgerald ML*, Kang K, Okuhira KI, Bell SA, Manning JJ, Koehn SL, Lu N, Moore KJ, Freeman MW. Abca7 null mice retain normal macrophage phosphatidylcholine and cholesterol efflux activity despite alterations in adipose mass and serum cholesterol levels. J Biol Chem. 2004 280:3989-89 PMID: 15550377

  20. Okuhira KI*, Fitzgerald ML*, Sarracino DA, Manning JJ, Bell SA, Goss JL, Freeman MW. Purification of ABCA1 and associated binding proteins reveals the importance of beta 1-syntrophin in cholesterol efflux. J Biol Chem. 2005, 79:48477-48485 PMID: 16192269  * Co-First Authors

  21. Huang ZH, Fitzgerald ML, Mazzone T. Distinct Cellular Loci for the ABCA1-Dependent and ABCA1-Independent Lipid Efflux Mediated by Endogenous Apolipoprotein E Expression. Arterioscler Thromb Vasc Biol. 2006 Jan;26(1):157-62. Epub 2005 Oct 27 PMID: 16254198

  22. Fitzgerald ML, Xavier R, Haley KJ, Welti R, Goss JL, Brown CE, Zhuang DZ, Bell SA, Lu N, McKee M, Seed B, Freeman MW. ABCA3 inactivation in mice causes respiratory failure, loss of pulmonary surfactant and depletion of lung phosphatidylglycerol. J Lipid Res. 2007, 48:621-632. PMID: 17142808

  23. Tamehiro N, Zhou S, Okuhira K, Benita Y, Brown CE, Zhuang DZ, Latz E, Hornemann T, von Eckardstein A, Xavier RJ, Freeman MW, Fitzgerald ML. SPTLC1 Binds ABCA1 to Negatively Regulate Trafficking and Cholesterol Efflux Activity of the Transporter. Biochemistry, 2008 Jun 10;47(23):6138-47. Epub 2008 May 17. PMID: 18484747

  24. Zuo, Z., Zhuang, D., Han, R., Isaac, G., Manning, J., McKee, M., Welti, R., Brissette, J., Fitzgerald, ML, and Freeman, MW. ABCA12 maintains the epidermal lipid permeability barrier by facilitating formation of ceramide linoleic esters. J Biol Chem.  2008 Dec 26; 283(52):36624-35. Epub 2008 Oct 27 PMID: 18957418
Reviews
  1. Reed, GL, Fitzgerald, ML., Polgar, J. (2000)Molecular mechanisms of platelet exocytosis: insights into the "secrete" life of thrombocytes. Blood. Nov 15;96(10):3334-42 PMID: 11071625

  2. Moore, KJ, Fitzgerald, ML, Freeman, MW. Peroxisome proliferator-activated receptors in macrophage biology: anti-inflammatory modulators? Curr. Opin. Lipidology, 2001 Oct;12(5):519-27. PMID: 11561171

  3. Fitzgerald, ML, Moore, KJ, Freeman, MW. Nuclear hormone receptors and cholesterol trafficking: the orphans find a new home. J. Mol. Medicine, 2002 May;80(5):271-81 PMID: 12021839




Journal of Lipid Research cover image highlighting our work conducted in collaboration with Dr. Mason Freeman analyzing the role of ABCA3 in the generation of lung surfactant lipids





Journal of Biological Chemistry cover image highlighting our report that described the functional importance of the ABCA1 C-terminal protein interaction domain
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