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| PROGRAM |
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| THURSDAY, MAY 7TH |
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| Noon - 1:30 PM |
Registration Begins
(Martin Conference Center Lobby / 77 Avenue Louis Pasteur ) |
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| 1:30 - 2:00 PM |
Opening Remarks |
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Kenneth Chien, MD, PhD Massachusetts General Hospital |
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Karl Tryggvason, MD, PhD Karolinska Institutet |
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Deborah Sweet, PhD Cell Press |
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| Keynote Lecture |
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| 2:00 - 3:00 PM |
Lee Hood, MD, PhD |
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Institute for Systems Biology, USA |
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Systems Medicine, Transforming Technologies and the Emergence of P4--Predictive, Personalized, Preventive and Participatory—Medicine |
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| 3:00 - 3:30 PM |
Break |
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| Session I: Confronting the Complexity of Human Disease |
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| Chair: Karl Tryggvason, MD, PhD |
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| 3:30 - 4:00 PM |
Stephen O'Rahilly, MD |
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University of Cambridge, UK |
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Dissecting the Metabolic Syndrome |
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| 4:00 - 4:30 PM |
Olle Lindvall, MD, PhD |
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Lund University Hospital, SE |
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Stem Cell Therapy for Neurodegenerative Disease—Will it Ever be Possible? |
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| Short Talk |
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| 4:30 - 4:50 PM |
Eric Schauberger |
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Michigan State University, USA |
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A New Locus on Chromosome 1p33 Increases Susceptibility to Asthma in Children |
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| 4:50 - 5:20 PM |
Christopher Walsh, MD, PhD |
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Children's Hospital Boston, USA |
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World-Wide, and Genome-Wide, Searches for Autism Genes |
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| 5:30 PM |
Welcome Reception |
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| FRIDAY, MAY 8TH |
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| 8:30 - 9:00 AM |
Breakfast / Registration |
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| Session II: Strategic Approaches to Stem Cell Application |
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| Chair: Douglas Melton, PhD |
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| 9:00 - 9:30 AM |
George Daley, MD, PhD |
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Children's Hospital Boston, USA |
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Patient-Specific Pluripotent Stem Cells |
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| 9:30 - 10:00 AM |
Johan Ericson, PhD |
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Karolinska Institutet, SE |
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Programming of ES Cell Differentiation by Intrinsic Transcriptional Determinants |
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| Short Talk |
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| 10:00 - 10:20 AM |
Je-Hyuk Lee, MD, PhD |
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Harvard Medical School, USA |
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Exploring Expression Regulatory Variants Using Allele-Specific Gene Expression in Human Induced Pluripotent Stem Cells |
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| 10:20 - 10:50 AM |
Break |
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| 10:50 - 11:20 AM |
Sangeeta Bhatia, MD, PhD |
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Massachusetts Institute of Technology and Howard Hughes Medical Institute, USA |
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Microscale Hepatic Tissue Engineering |
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| 11:20 - 11:50 AM |
Peter Schultz, PhD |
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The Scripps Research Institute, USA |
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A Chemical Approach to Stem Cell Biology |
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| 11:50 AM - 12:30 PM |
Lunch |
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| 12:30 - 2:30 PM |
Poster Session I |
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| Session III: Disease Physiology - The Individual as a System |
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| Chair: Katherine High, MD |
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| 2:30 - 3:00 PM |
Helen Hobbs, MD |
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University of Texas Southwestern, USA |
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Genetic Protection from Diseases of Dietary Excess |
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| 3:00 - 3:30 PM |
Richard Lifton, MD, PhD |
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Yale School of Medicine, USA |
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Extreme Outliers as Models of Common Human Disease |
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| Short Talk |
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| 3:30 - 3:50 PM |
Keval Chandarana |
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University College London |
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Involvement of Peptide YY in Bodyweight Changes Through Diet and Surgery |
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| 3:50 - 4:20 PM |
Break |
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| 4:20 - 4:50 PM |
Gerald Shulman, MD, PhD |
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Yale University and Howard Hughes Medical Institute, USA |
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Cellular Mechanisms of Insulin Resistance: Implications for Obesity, Lipodystrophy, Metabolic Syndrome and Type 2 Diabetes |
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| 4:50 - 5:20 PM |
Nils-Göran Larsson, MD, PhD |
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Max Planck Institute for Biology of Ageing, DE |
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Regulation of mtDNA Expression in Disease and Ageing |
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| Special Session: The Future for Physician Scientists |
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Chairs: Deborah Sweet, PhD and Sean Wu, MD, PhD
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| 5:30 PM |
Marc Tessier-Lavigne, PhD |
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Genentech, USA |
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| 5:50 PM |
Pamela Sklar, MD, PhD |
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Massachusetts General Hospital, USA |
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| 6:10 - 6:30 PM |
Discussion |
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| 7:00 PM |
Conference Dinner |
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Museum of Fine Arts, Boston (465 Huntington Avenue) |
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Titian, Tintoretto, Veronese: Rivals in Renaissance Venice |
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| SATURDAY, MAY 9TH |
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| 8:30 - 9:00 AM |
Breakfast / Registration |
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| Session IV: Individual Variation as a Parameter that Defines Disease |
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| Chair: Lee Hood, MD, PhD |
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| 9:00 - 9:30 AM |
David Cox, MD, PhD |
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Pfizer, USA |
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Human Genetic Variation and Improved Health Outcomes |
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| 9:30 - 10:00 AM |
David Altshuler, MD, PhD |
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Harvard Medical School and Massachusetts General Hospital |
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Genomic Variation and the Inherited Basis of Common Disease |
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| Short Talk |
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| 10:00 - 10:20 AM |
Alison Van Dyke |
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Wayne State University and Karmanos Cancer Institute |
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A Three-Stage Multipathway Analysis of Associations between SNPs and Lung Cancer among Women |
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| 10:20 - 10:50 AM |
Break |
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| 10:50 - 11:20 AM |
Pamela Sklar, MD, PhD |
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Massachusetts General Hospital, USA |
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Genetics and Genomics of Bipolar Disorder and Schizophrenia |
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| 11:20 - 11:50 AM |
Rene Bernards, PhD |
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The Netherlands Cancer Institute, NL |
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Finding Mechanisms and Biomarkers of Drug Resistance in Cancer |
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| 11:50 AM - 12:30 PM |
Lunch |
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| 12:30 - 2:30 PM |
Poster Session II |
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| Session V: The Future of Individualized Medicine |
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| Chair: Kenneth Chien, MD, PhD |
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| 2:30 - 3:00 PM |
Jonathan Irish PhD |
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Stanford University, USA |
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Connecting Mechanism and Outcome at the Single Cell Level |
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| 3:00 - 3:30 PM |
Katherine High, MD |
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Children's Hospital of Philadelphia and Howard Hughes Medical Institute, USA |
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Gene Therapy for Inherited Disorders: Hemophilia and Leber’s Congenital Amaurosis |
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| Short Talk |
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| 3:30 - 3:50 PM |
Roxanna Irani |
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University of Texas, USA |
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Hypertension in Pregnancy: Early Screening and Therapeutic Possibilities |
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| 3:50 - 4:20 PM |
Break |
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| 4:20 - 4:50 PM |
Mildred Cho, PhD |
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Stanford University, USA |
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The Future of Individualized Medicine: Can We Get There From Here? |
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| 4:50 - 5:20 PM |
Marc Tessier-Lavigne, PhD |
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Genentech, USA |
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Drug Discovery and the Prospects for Personalized Medicine |
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| 5:20 - 5:30 PM |
Closing Remarks |
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Orla Smith, PhD Cell Press |
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Kenneth Chien,MD, PhD Massachusetts General Hospital |
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Karl Tryggvason, MD, PhD Karolinska Institutet |
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