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| Event Flyer (.PDF) |
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| Event Program (.PDF) |
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| Thursday, May 20th |
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| Noon |
Registration Begins |
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| 1:30 PM |
Opening Remarks |
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| 2:00 PM |
Keynote Address |
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George Church |
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Harvard Medical School |
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Technologies for Reading, Writing & Arithmetic of Omes |
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| 3:00 PM |
Break |
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| Session One: Innovative Technologies in Systems Biology |
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| Chair: Goran Hansson, Karolinska Institutet |
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| 3:30 PM |
Michael Snyder |
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Stanford University School of Medicine |
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Transcription Binding Variation in Eucaryotes |
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| 4:00 PM |
Ruedi Aebersold |
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ETH Zurich, Institute of Molecular Systems Biology |
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Proteomic analysis of Pertubed Networks in Cancer, In Situ and Remotely |
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| 4:30 PM |
Effat Emamian (Short Talk) |
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Advanced Technologies for Novel Therapeutics |
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Molecular Fault Diagnosis Engineering: A Novel Systems Biology Approach for Finding Faulty Molecules in Complex Human Disorders |
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| 4:50 PM |
Lani Wu |
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University of Texas Southwestern |
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Cellular Heterogeneity in Models of Cancer and Metabolism: Which Differences Make a Difference? |
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| 5:30 PM |
Tour Sci Life Lab at KI |
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| 7:00 PM |
Welcome Reception (The City Hall of Stockholm) |
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| Friday, May 21st |
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| Session Two: Systems Level Approaches to Cancer |
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| Chair: Steven Altschuler, University of Texas Southwestern |
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| 8:30 AM |
Registration |
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| 9:00 AM |
Aviv Regev |
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The Broad Institute |
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Unbiased Reconstruction of Mammalian Regulatory Networks |
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| 9:30 AM |
Scott W. Lowe |
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Howard Hughes Medical Institute & Cold Spring Harbor Laboratory |
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Constructing and Deconstructing Cancer using Mouse Models and RNAi |
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| 10:00 AM |
Catherine Spina (Short Talk) |
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Boston University |
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Rebooting Breast Cancer: Novel Insights from Network Inference |
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| 10:20 AM |
Break |
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| 10:50 AM |
Judy Lieberman |
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Harvard Medical School |
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Tumor Suppressor microRNAs: Master Regulators of Cell Proliferation and Differentiation |
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| 11:20 AM |
Jussi Taipale |
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University of Helsinki and Karolinska Institutet |
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Systems Biology of Cancer |
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| Noon |
Lunch |
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| 12:30 PM |
Poster Session I |
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| Session Three: Metabolic Disease from the Systems Perspective |
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| Chair: Jesper Tegner, Karolinska Institutet |
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| 2:30 PM |
Juleen R. Zierath |
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Karolinska Institutet |
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DNA Methylation in Type 2 Diabetes and Obesity: Influence on Insulin Sensitivity |
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| 3:00 PM |
Debbie M. Muoio |
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Duke University |
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Comprehensive Metabolic Profiling for Understanding Obesity-Related Energy Dysregulation |
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| 3:30 PM |
Benjamin T. Bikman (Short Talk) |
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Duke-NUS Graduate Medical School |
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Mechanism of Inflammation-Induced Insulin Resistance: Reliance of Toll-Like Receptor-4 (TLR4) Action on Ceramide Synthesis Reveals Roles for Saturated Fatty Acids |
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| 3:50 PM |
Break |
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| 4:20 PM |
Sadaf Farooqi |
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University of Cambridge |
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Molecular Mechanisms Involved in Human Obesity |
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| 4:50 PM |
D. Grahame Hardie |
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University of Dundee |
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AMPK as a Drug Target in both Diabetes and Cancer - Too Good to be True? |
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| Trainee Session (5:30 - 6:30 PM) |
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| Chairs: Nikla Emambokus, Cell Press and Lara Szewczak, Cell Press |
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Jussi Taipale |
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University of Helsinki and Karolinska Institutet |
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Judy Lieberman |
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Harvard Medical School |
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Lani Wu |
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University of Texas Southwestern |
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| 7:30 PM |
Welcome Drink and Conference Dinner (Moderna Museet)
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| Saturday, May 22nd |
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| Session Four: Metabolism and Cancer - Targeting Common Pathways |
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| Chair: Juleen R. Zieerath, Karolinska Institutet |
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| 8:30 AM |
Registration |
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| 9:00 AM |
Lewis Cantley |
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Harvard Medical School |
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PI 3-Kinase and Cancer Metabolism |
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| 9:30 AM |
Michael N. Hall |
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University of Basel |
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TOR Signaling and the Control of Cell and Animal Growth |
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| 10:00 AM |
Dennis Vitkup (Short Talk) |
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Columbia University |
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Cancer-Induced Changes in Expression of the Human Metabolic Network |
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| 10:20 AM |
Break |
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| 10:50 AM |
Steve Shoelson |
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Joslin Diabetes Center / Harvard Medical School |
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Moving Away from the One Target-One Drug Paradigm in Aging- and Obesity-Related Conditions |
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| 11:20 AM |
Tak W. Mak |
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University of Toronto |
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Tumour Cell Survival under Metabolic Stress |
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| Noon |
Lunch |
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| 12:30 PM |
Poster Session II |
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| Session Five: Systems Biology in Drug Development |
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| Chair: Hans Jornvall, Karolinska Institutet |
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| 2:30 PM |
Xiaodong Wang |
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Howard Hughes Medical Institute & University of Texas Southwestern |
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Endoplasmic Reticulum UDPase ENDPT-5 Promotes Cell Growth in the PI3K/PTEN Pathway |
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| 3:00 PM |
Philippe Bastiaens |
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Max Plank Institute of Molecular Physiology, Dortmund |
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Spatial Regulation of Growth Factor Signaling |
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| 3:30 PM |
Steven B. Heymsfield |
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Merck & Co. |
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Pharmacologic Agents as Molecular Probes of Human Energy Balance Regulatory Systems |
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| 4:00 PM |
Break |
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| 4:30 PM |
Giulio Superti-Furga |
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Research Center for Molecular Medicine of the Austrian Academy of Sciences |
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Molecular Networks in Leukemia and Innate Immunity |
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| 5:00 PM |
Ravi Iyengar |
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Mount Sinai School of Medicine |
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Systems Pharmacology for Adverse Event Prediction and Multi-target Based Therapy |
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| 5:30 PM |
Closing Remarks |
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