The Cardiovascular Research Center at Massachusetts General Hospital


Sean Wu

Sean Wu

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Members
Members

Wen-Pin Chen, Ph.D.
Wen-Pin Chen received his Ph.D. from National Taiwan University. After completing my thesis work in Professor Ming-Jai Su’s Lab in the Institute of Pharmacology about the mechanisms of the mechanical and electrophysiological modulation of a1-adrenergic activation in normal and cardiomyopathic hearts in 2002. And then, he joined in Drug Research Center at NTU as a postdoctoral fellow to have charge in cardiovascular pharmacology projects including anti-arrhythmic and cardioprotective agents against ischemia-reperfusion injury, drugs anti-diabetic cardiovascular complications and drugs anti-septic cardiomyopathy since 2002. His major research work included using patch clamp technique to characterize the change of cardiac electrophysiology under pathophysiological conditions and the modulation by drugs, measuring Ca2+ transients of single cardiac cells, and using catheter to measure left ventricular pressure and volume to approach hemodynamic function in normal and disease animal models. Being interested in pharmacological screen for drugs that regulate postnatal cardiac progenitor cells, he enters cardiovascular research center of MGH as a research fellow.

 
Marc EnglesMarc Engels, M.D.
Marc Engels grew up and graduated from high school in Curaçao, a Caribbean island forming part of the Dutch Antilles. He attained his propaedeutic exam in Life Science & Technology at Leiden University and Technical University Delft in the Netherlands,  before entering Medical School at Leiden University. He combined his studies with a pre-Master program in Biomedical Sciences. After graduating from Medical School in 2009 he joined the Wu lab to work on cardiac stem cell research under the direct mentorship of Sean Wu. Marc is hoping to start with a PhD-training later this year.
 
Serge GregoireSerge Gregoire, Ph.D.
Serge Gregoire attended the University of Sherbrooke in Quebec, Canada, from 1999-2001 for his undergraduate training. He majored in biology specializing in biotechnology. This allows him to be recruited in the laboratory of Dr. Xiang-Jiao Yang in the department of Experimental Medicine at McGill University to pursue his Ph.D. training. He studied the molecular regulatory mechanisms of Myocyte Enhancer Factor 2 (MEF2) family of transcription factors. He has shown that histone deacetylase 4 modulates the sumoylation and phosphorylation of MEF2 proteins. This has allowed him to identify a phospho-sumoyl switch. He has demonstrated that this motif is present in more than 80 proteins and that it serves as a valuable signature for in silico identification of proteins regulated by adjacent phosphorylation and sumoylation. More importantly, the proteins identified by such screening play critical roles in cancer formation/progression, cell signaling, stemness, metabolism, and cytoskeletal regulation, highlighting the physiological significance of this motif.
 
Markus KraneMarkus Krane, M.D.
Markus Krane graduated from the Ludwig Maximillians University School of Medicine in Munich, Germany in 2004. He performed his medical thesis in cardiopulmonary bypass in a pig model in the Department of Experimental Surgery (Prof. Dr. Robert Bauernschmitt) of the German Heart Center Munich. After graduating from medical school he has started his cardiac surgery fellowship training at the German Heart Center Munich in the Department of Cardiovascular Surgery (Prof. Dr. Rüdiger Lange) in 2005. Being interested in embryonic and induced pluripotent stem cell biology in the context of cardiac differentiation/development he has entered the Wu Lab of the cardiovascular research center at the MGH as a research fellow in 2009.
 
Rajarajan Kuppusamy, Ph.D.
Rajarajan Kuppusamy is a Veterinary Graduate, completed his Bachelor of Veterinary Science at Madras Veterinary College, Chennai, India. He did his Master of Veterinray Science in Animal Physiology at S.V. Veterinary University, Tirupati, India. He completed his Ph.D in Animal Physiology at Indian Veterinary Research Institute, India. For his doctoral degree he worked on In Vitro Fertilization & embryo genomics. He worked as Scientist for three years at Center for Cellular and Molecular Biology (CCMB), Hyderabad, India.  At CCMB, he worked in various Assisted Reproductive Technologies- Somatic Cell Nuclear Transfer, IVF, ICSI, Transgenic and Knock-out mice, Cryopreservation of embryos and oocytes and Cell culture. Being interested in ES cells and iPS cells, Assisted Reproductive Technology, transplantation research and regenerative biology, he joined Wu Lab as a research fellow in June 2009.
 
Alyssa Riley, B.S.
Alyssa graduated from the University of Massachusetts Amherst in 2004 with a BS in Animal Science. That summer, she joined the CBR Institute for Biomedical Research at Children's Hospital Boston working under Yuko Fujiwara in Fred Alt and Stuart Orkin's transgenic core. Her interests in reproductive physiology led her to Charles River Laboratories working as a reproductive specialist, primarily rederiving investigators' mouse lines.  Currently, she is the transgenic core manager for Wu lab, primarily injecting ES and IPS cells into mouse blastocysts. In June 2010 she is attending the cryopreservation of mouse germplasm course at Jackson Laboratory and hopes with its completion, will be added to the transgenic core's services.  
 
 
Alumni
 
Xiaojing HuangXiaojing Huang, B.A.
Xiaojing graduated from Princeton in 2008 with a BA in chemistry, working on mathematical modelling theory for dynamic systems. Her current interests include cardiac regenerative therapy and the development of IPS disease models.
 
Yaun-Hung ImageYuan-Hung Liu, M.D.
Yuan-Hung Liu was graduated from National Taiwan University School of Medicine in Taipei, Taiwan. He subsequently received internal medicine residency and cardiology fellowship training at National Taiwan University Hospital. Yuan-Hung Liu became CV staff at Far Eastern Memorial Hospital in Taipei in July, 2002. He took responsibility of intensive care and resident training in cardiovascular intensive care unit from 2002 to 2003. Being interested in cardiac electrophysiology, he received cardiac electrophysiology (EP) fellowship training at National Taiwan University Hospital from 2003 to 2006, and then set up EP Lab at Far Eastern Memorial Hospital.
 
James OhJames Oh, B.S.
James Oh graduated from LaGuardia High School for Music and Art in New York, NY. He completed his undergraduate training at the University of North Carolina at Chapel Hill in 2007. While majoring in physics and philosophy, he completed his thesis in biology in Stephen Crews' laboratory where he studied transcriptional regulation. At UNC, James began a stem cell interest group for ethics debates. Furthermore, he has received undergraduate training in Michael Young's lab at The Rockefeller University where he investigated the role circadian proteins.
 
Esther Yu, B.S.
Esther Yu graduated from Centennial High School in Roswell, GA. She completed her undergraduate training at the Massachusetts Institute of Technology in 2007. Along with majoring in biology at MIT, she worked in the lab of Thijn Brummelkamp at the Whitehead Institute, where she performed RNAi screens to identify and characterize novel genes in various cancer pathways. Furthermore, she investigated methods to use RNAi to selectively target tumorogenic cells.
 
Min Zeng, M.D.
Min Zeng graduated from the West China University of Medical Science (Sichuan, China). Subsequently she worked in The First affiliated Hospital of The West China University of Medical Science, and Hainan Provincial People's Hospital majoring in cardiology. She participated in the research of the effect evaluation of nasal continuous positive air pressure (n-CPAP) treatment in patient with acute coronary syndrome (ACS) and sleep apnea syndrome (SAS) which was sponsored by Ministry of Health, P.R. China in 2002.And in 2004, she undertook the research financed by Hainan provincial health bureau: A follow up study of incidence of stroke and risk factors in patients with Nonvalvular Atrial Fibrillation(NVAF). Because she has a burgeoning interested in the formation of early stage myocardial lineage commitment by a molecular genetic approach, she joined the Wu lab as a postdoctoral fellow in 2007.
Massachusetts General Hospital the cardiovascular research center