Lab Overview
Small molecules can be invaluable tools for studying and treating diseases, but discovering novel small molecules is a difficult and risky process. Many of the challenges of small molecule discovery stem from the inability of in vitro assays to model the complex physiology of disease. Consequently, the in vitro assays used in small molecule discovery are poor predictors of the beneficial and adverse effects of the small molecule when translated to an in vivo setting. We are circumventing these problems by performing high throughput small molecule discovery in vivo using zebrafish as a model organism. Areas of interest include cardiovascular disease, anemia, leukemia, and psychiatric disease.
Recent News
• Congratulations to Joanna Yeh and Kathleen Munson for their recent publication in Nature Chemical Biology
• Congratulations to Charles Hong and Chetana Sachidanandan for their recent publication in Nature Medicine
• Congratulations to David Kokel for his recent review article in Briefings in Functional Genomics and Proteomics
• Congratulations to Joanna Yeh for being awarded a Mentored Research Scientist Development Award (K01) from the NIH and a Clafflin Award from the MGH
back to top |
