The Cardiovascular Research Center at Massachusetts General Hospital


Farouc Jaffer

Farouc Jaffer

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Lab Overview

Our laboratory is developing in vivo molecular imaging and theranostic approaches to visualize and treat vascular disease, including atherosclerosis, thrombosis, and vascular injury. A primary focus of the laboratory is the development of optical (fluorescence microscopy, reflectance imaging, tomography), integrated nuclear–computed tomography (SPECT/CT, PET/CT), and MRI approaches to visualize protease activity, cellular inflammation, and transglutaminase activity. Theranostic approaches are utilizing light-activated targeted nanoparticles for reducing plaque inflammation. The laboratory interacts closely with the MGH Center for Molecular Imaging Research and the Advanced Microscopy Center. Finally we are developing novel intravascular near infrared fluorescence (NIRF) catheter technology in large animals. Successful prototypes are anticipated to undergo clinical testing in human coronary arteries to identify inflamed, high-risk plaques.





Figure 1.
In vivo near infrared fluorescence imaging of cysteine protease activity in atherosclerotic plaques.




Figure 2.
In vivo MRI and ex vivo optical imaging of cellular inflammation in apoE -/ mice using magnetofluorescent nanoparticles.


Collaborative Relationships
Farouc Jaffer's group is part of the Vascular + Metabolic and Translational Medicine programs.

Publications
Click here to view Farouc Jaffer's publications.

For patients interested in seeing Dr. Jaffer in his clinical practice, click here to find out more or call the MGH Heart Center at 866-MGH-8910.


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