Center for the Study of Inflammatory Bowel Disease
19th Annual Symposium
Thursday, November 12, 2009
7:45 a.m. - 12:30 p.m.
| 7:45 - 8:25 | Registration and Breakfast Opening Remarks - Ramnik J. Xavier, M.D. - Director, CSIBD Session Moderator: Christian Reinecker, M.D. |
| 8:30 - 8:50 | Epithelial Ras Isoforms Modulate Inflammatory Response Kevin Haigis, Ph.D., Department of Pathology Massachusetts General Hospital |
| 8:55 - 9:15 | Identification of Intracellular Bacteria in Patients with Crohn's Disease and Autophagy Mutations Joshua Korzenik, M.D., Gastrointestinal Unit Massachusetts General Hospital |
| 9:20 - 9:40 | Sheepish B Cells Atsushi Mizoguchi, M.D., Ph.D., Department of Pathology Massachusetts General Hospital |
| 9:45 - 10:05 | Bone Marrow Stromal Cell Grafts for the Treatment of Colitis Biju Parekkadan, Ph.D., Department of Surgery Massachusetts General Hospital |
| 10:10 - 10:30 | Break |
| 10:35 - 10:55 | Progress in Gene Discovery in IBD Mark Daly, Ph.D., Center for Human Genetics Massachusetts General Hospital and Broad Institute |
| 11:00 - 11:20 | RNAi Screens: Uncovering Host-Viral Interactions Abraham Brass, M.D., Ph.D., Gastrointestinal Unit Massachusetts General Hospital |
| Special Invited Guest Speaker | |
| 11:30 - 12:30 | Restraining TLR Signaling: Regulation of Diet-Induced Obesity by the
RP105/TLR Axis Christopher Karp, M.D., Cincinnati Children's Hospital Medical Center |
Simches Research Building at Charles River Plaza
185 Cambridge Street, 3rd floor
The Symposium is open to the research community at no charge. To register, please e-mail Mariane Leonard
19th Annual Workshop
Integrating Innate and Adaptive Immunity in Complex Human Diseases
| Friday, November 13, 2009 | |
| 7:30 - 7:55 | Registration and Continental Breakfast Opening Remarks - Ramnik J. Xavier, M.D., Director, CSIBD |
| Session I: | INNATE IMMUNITY - REGULATION Moderators: Benjamin Medoff, M.D., and John Rioux, Ph.D. |
| 8:00 - 8:20 | IMD Pathway and Drosophila Innate Immunity Neal Silverman, Ph.D., University of Massachusetts Medical School, Boston, MA |
| 8:25 - 8:45 | Dissection of C. elegans Host Response to Infection Frederick Ausubel, Ph.D., Massachusetts General Hospital, Boston, MA |
| 8:50 - 9:10 | CARD9 and Innate Immunity Takashi Saito, Ph.D., RIKEN Center for Allergy and Immunology, Yokohama, Japan |
| 9:15 - 9:35 | Kinetic Control and Negative Feedback Loops in NF-KB Signaling Alexander Hoffmann, Ph.D., University of California, San Diego, CA |
| 9:40 - 10:00 | Discussion |
| 10:05 - 10:20 | Break |
| Session II: | TLR'S, NALPS AND DANGER SIGNALS Moderators: Fabio Cominelli, M.D., Ph.D., and Gail Hecht, M.D. |
| 10:25 - 10:45 | Innate Immunity and Allergenicity Christopher Karp, M.D., Cincinnati Children's Hospital Medical Center, Cincinnati, OH |
| 10:50 - 11:10 | NALP Proteins and Inflammsome Assembly Jurg Tschopp, Ph.D., University of Lausanne, Switzerland |
| 11:15 - 11:35 | Ubiquitin and Immunity Averil Ma, M.D., University of California, San Francisco, CA |
| 11:40 - 12:00 | NODS, NALPS Immunity Warren Strober, M.D., National Institutes of Health, Bethesda, MD |
| 12:05 - 12:25 | Discussion |
| 12:30 - 1:25 | Lunch |
| Session III: | LYMPHOCYTE ACTIVATION Moderators: Claudio Fiocchi, M.D., and Charles Elson III, M.D. |
| 1:30 - 1:50 | Transcriptional Regulation in CD4 Lymptocytes Anjana Rao, Ph.D., Harvard Medical School, Boston, MA |
| 1:55 - 2:15 | Transcriptional Control in CD8 T Cells Kenneth M. Murphy, M.D., Ph.D., Washington University School of Medicine in St. Louis, MO |
| 2:20 - 2:40 | Transciptional Regulation of Th17 Cells Liang Zhou, M.D., Ph.D., Feinberg School of Medicine, Northwestern University, Chicago, IL |
| 2:45 - 3:05 | Natural and Adapative Foxp3+ Regulatory T Cells: More of the Same or a Division of
Labor Juan Lafaille, Ph.D., New York University School of Medicine, New York, NY |
| 3:10 - 3:30 | Discussion |
| 3:35 - 3:50 | Break |
| Session IV: | INNATE IMMUNE SIGNALS AND ADAPTIVE IMMUNITY Moderators: Lloyd Mayer, M.D., and Atul Bhan, M.D. |
| 3:55 - 4:15 | ITAM Signals in DCs for CD4+ T Cell Priming Wojciech Swat, Ph.D., Washington University School of Medicine, St. Louis, MO |
| 4:20 - 4:40 | Innate Control of Adaptive Immunity Ruslan Medzhitov, Ph.D., Yale University School of Medicine, New Haven, CT |
| 4:45 - 5:05 | Reconstructing Regulatory Circuits in Pathogen Sensing Responses Aviv Regev, Ph.D., Broad Institute, MIT and Harvard, Cambridge, MA |
| 5:10 - 5:30 | Discussion |
| Saturday, November 14, 2009 | |
| 7:30 - 8:00 | Registration and Continental Breakfast Remarks |
| Session V: | IMMUNE CONTROLLERS AND ADAPTIVE IMMUNITY Moderators: Andrew Luster, M.D., Ph.D., and Christian Reinecker, M.D. |
| 8:05 - 8:25 | B Cells Immune Responses and Autoimmunity Shiv Pillai, M.D., Ph.D., Massachusetts General Hospital, Boston, MA |
| 8:30 - 8:50 | A Mouse Model for the Immune Surveillance of EBV Infected B Cells and Human Posttransplant Lymphoproliferative Disorder Klaus Rajewsky, Ph.D., Harvard Medical School, Boston, MA |
| 8:55 - 9:15 | Invivo Analysis of Dendritic Cell Development and Homeostasis Michel C. Nussenzweig, M.D., Ph.D., The Rockefeller University, New York, NY |
| 9:20 - 9:35 | Discussion |
| Session VI: | MICROBES, IMMUNITY AND DISEASE MODELS Moderators: Cox Terhorst, Ph.D., and Judy Cho, M.D. |
| 9:40 - 10:00 | Initiation of Arthritis in Response by Commensal Bacteria Diane Mathis, Ph.D., Joslin Diabetes Center, Boston, MA |
| 10:05 - 10:25 | Regulatory Lymphocytes and Intestinal Inflammation Fiona Powrie, M.D., Oxford University, Oxford, United Kingdom |
| 10:30 - 10:50 | Linking Innate and Adapative Immunity in Celiac Disease Bana Jabri, M.D., Ph.D., The University of Chicago, Chicago, IL |
| 10:55 - 11:10 | Discussion |
| Session VII: | COMMUNICATION BETWEEN INNATE AND ADAPTIVE IMMUNITY IN THE INTESTINAL MUCOSA Moderators: Balfour Sartor, M.D., and Scott Snapper, M.D., Ph.D. |
| 11:15 - 11:35 | Crohn's Disease Linking Innate to Adaptive Immunity Charles Elson III, M.D., University of Alabama, Birmingham, AL |
| 11:40 - 12:00 | Genetics and Biology of TL1A: A Central Regulator of Normal and IBD Mucosal Immunity Stephan Targan, M.D., Cedars Sinai Medical Center, Los Angeles, CA |
| 12:05 - 12:25 | Basophils and Mucosal Immunity David Artis, Ph.D., University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA |
| 12:30 - 12:50 | Macrophage's Coordinate Sentinel Responses in Intestinal Immunity Scott E. Plevy, M.D., University of North Carolina School of Medicine, Chapel Hill, NC |
| 12:55 - 1:15 | Negative Regulators of Innate Immunity Luke O'Neill, Ph.D., University Dublin Trinity College, Dublin, Ireland |
| 1:20 - 1:40 | Innate Immunity in HIV-1 Infection Marcus Altfeld, M.D., Ph.D., Ragon Institute of MGH, MIT, and Harvard, Charlestown, MA |
| 1:45 - 2:00 | Discussion |
| 2:05 | Lunch |
Autophagy in Immunity
Massachusetts General Hospital's
Center for the Study of Inflammatory Bowel Disease
18th Annual Workshop
November 14 - 15, 2008
CONFIRMED SPEAKERS:
- Tamotsu Yoshimori, Ph.D., Osaka University, Japan
- Anna Maria Cuervo, M.D., Ph.D., Albert Einstein College of Medicine, Bronx, NY
- Beth Levine, M.D., University of Texas Southwestern Medical Center, Dallas, TX
- Craig B. Thompson, M.D., University of Pennsylvania, Philadelphia, PA
- Jurg Tschopp, Ph.D., University of Lausanne, Switzerland
- Eric Baehrecke, Ph.D., University of Massachusetts Medical School, Worcester, MA
- Ramnik J. Xavier, M.D., Massachusetts General Hospital, Boston, MA
- Herbert W. Virgin IV, M.D., Ph.D., Washington University School of Medicine, St. Louis, MO
- John H. Brumell, Ph.D., The Hospital for Sick Children, Toronto, Ontario, Canada
- Vojo Deretic, Ph.D., University of New Mexico HSC, Albuquerque, NM
- Christian Munz, Ph.D., University Hospital Zurich, Switzerland
- Akiko Iwasaki, Ph.D., Yale University School of Medicine, New Haven, CT
- Noboru Mizushima, M.D., Ph.D., Tokyo Medical and Dental University, Tokyo, Japan
- Junying Yuan, Ph.D., Harvard Medical School, Boston, MA
- Christophe Benoist, M.D., Ph.D., Joslin Diabetes Center, Boston, MA
- Wojciech Swat, Ph.D., Washington University School of Medicine, St. Louis, MO
- Alfred Lewis Goldberg, Ph.D., Harvard Medical School, Boston, MA
- John J. LeMasters, M.D., Ph.D., Medical University of South Carolina, Charleston, SC
- James E. Bradner, M.D., Dana Farber Cancer Institute, Boston, MA
Simches Research Building at Charles River Plaza
185 Cambridge Street, 3rd floor, Boston, MA
The Workshop is open to the research community at no charge.
To register, please e-mail mleonard1@partners.org
PRE-REGISTRATION REQUIRED
17th Annual Symposium
Thursday, November 8, 2007
| Effect of Chitin Administration on Colitis Emiko Mizoguchi, M.D., Ph.D., Gastrointestinal Unit Massachusetts General Hospital |
Microendoscopy for In Vivo Cellular Imaging of Inflammatory Bowel Disease Seok Hyun (Andy) Yun, Ph.D., Wellman Center for Photomedicine Massachusetts General Hospital |
| p38 MAP Kinase Signaling in Macrophages Jin Mo Park, Ph.D., Cutaneous Biology Research Center Massachusetts General Hospital |
SIAE Mutations and Autoimmunity Shiv Pillai, M.D., Ph.D., Cancer Center Massachusetts General Hospital |
| Proteomics Approaches to Biomarker Discovery in Inflammatory Bowel Disease Kenneth E. Hung, M.D., Harvard Partners Center for Genetics and Genomics Massachusetts General Hospital |
CCR4-Dependent Regulatory T Cell Function in Inflammatory Bowel Disease Shannon Bromley, Ph.D., Center for Immunology and Inflammatory Diseases Massachusetts General Hospital |
| Genetic Analysis of Innate Immune Sensing and Response Bruce Beutler, M.D., The Scripps Research Institute, La Jolla, CA |
Annual Workshop: November 9 - 10, 2007
Host-Microbial Interactions at Mucosal Surfaces in Health and Disease
| Session I: Mapping The Flora | |
| Diversity Of The Human Intestinal Microbial Flora David Relman, M.D., Stanford University School of Medicine, Stanford, CA |
Metagenomic Analysis Of Human Distal Gut Microbiome Karen Nelson, Ph.D., Institute for Genomic Research, Rockville, MD |
| Host-Bacterial Mutualism Margaret McFall-Ngai, Ph.D., University of Wisconsin, Madison, WI | Session II: Influence Of Microbiota On Development Of Immune Response |
| Sampling Of Commensals And Induction Of Iga Andrew MacPherson, Ph.D., McMaster University Medical Center, Ontario, Canada |
Symbiotic Commensal Bacteria Direct Maturation Of The Host Immune System Dennis Kasper, M.D., Brigham and Women’s Hospital, Boston, MA |
| Immunoregulation Of Allergic And Inflammatory Disease By The Commensal Flora Cathryn Nagler, Ph.D., Massachusetts General Hospital, Boston, MA |
Sampling And Presentation Of Enteric Antigens Hans-Christian Reinecker, M.D., Massachusetts General Hospital, Boston, MA | Session III: Innate Microbial Recognition I |
| Communicable Ulcerative Colitis Induced By T-Bet Deficiency In The Innate Immune System Laurie Glimcher, M.D., Harvard School of Public Health, Boston, MA |
Innate Immune Signaling At The Intestinal Mucosal Surface Elke Cario, M.D., University of Essen, Essen, Germany |
| TLR-Commensal Interactions In Health And Disease Ruslan Medzhitov, Ph.D., Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT |
Genetic Analysis Of Innate Immunity Bruce Beutler, M.D., The Scripps Research Institute, La Jolla, CA | Session IV: Innate Microbial Recognition II |
| Tolerance To Intestinal Self Shannon Turley, Ph.D., Dana Farber Cancer Institute, Boston, MA |
Postnatal Acquisition Of Endotoxin Tolerance In Intestinal Epithelial Cells Mathias Hornef, M.D., University of Freiburg, Freiburg, Germany |
| Critical Role Of TLR:NF-_B Signaling In Commensal Bacteria Induced Colitis Christian Jobin, Ph.D., University of North Carolina at Chapel Hill, Chapel Hill, NC |
Intestinal Macrophages Play A Key Role In Th1 Dominant Chronic Colitis Through Excess Production Of IL12 And IL23 In Response To Bacteria Tadakazu Hisamatsu, M.D., Keio University School of Medicine, Tokyo, Japan | Session V: Role Of Microbes In Generation Of IL-23/Th17 Axis |
| Differential Activity Of IL-12 And IL-23 In Mucosal And Systemic Innate Immune Pathology Fiona Powrie, Ph.D., University of Oxford, Oxford, UK |
Regulation Of Inflammatory T Cells Chen Dong, Ph.D., University of Texas, Houston, TX |
| IL-23 And IL-27 – Related But Functionally Distinct Regulators Of Inflammation Daniel J. Cua, Ph.D., Schering-Plough Biopharma, Palo Alto, CA |
Roles of ROR_t And Foxp3 In Balancing Inflammation Dan R. Littman, M.D., Ph.D., Skirball Institute, NYU School of Medicine, New York, NY |
| IL-23 Plays A Key Role In Helicobacter Hepaticus Induced T Cell Dependent Colitis Marika Kullberg, Ph.D., The University of York, York, UK |
Session VI: Microbe Induced Immunoregulation (And Dysregulation In IBD) |
| Mucosal Effector Memory T Cells Hilde Cheroutre, Ph.D., La Jolla Institute for Allergy and Immunology, San Diego, CA | Regulatory T Cells In The Maintenance Of Mucosal Homeostatis And Prevention Of Intestinal Inflammation Scott Snapper, M.D., Ph.D., Massachusetts General Hospital, Boston, MA |
| Foxp3+ Regulatory T Cells In The Intestinal Lamina Propria Yasmine Belkaid, Ph.D., Laboratory of Parasitic Diseases NIAID, Bethesda, MD |
Tight Mucosal Compartmentation Of The Murine Immune Response To Antigens Of The Enteric Microbiota Charles Elson, M.D., University of Alabama, Birmingham, AL |
| Role Of Commensal Sensing In B Cell Mucosal Immunoregulation Jonathan Braun, M.D., Ph.D., UCLA School of Medicine, Los Angeles, CA |
|
16th Annual Symposium
Thursday, November 9, 2006
| Role of Chitinase 3-like-1 in Inflammatory Bowel Disease Emiko Mizoguchi, M.D., Ph.D. Gastrointestinal Unit, Massachusetts General Hospital |
Molecular Mechanism of the Anti-Inflammatory Effect of N-3 Fatty Acids in Fat-1 Transgenic Mice with DSS-Induced Colitis Jing X. Kang, M.D., Ph.D., Department of Cardiac Nutrition Massachusetts General Hospital |
| High Throughput Approaches to Dissecting Signaling Pathways Ramnik Xavier, M.D., Gastrointestinal Unit Massachusetts General Hospital |
Impact of Telomere Dysfunction on Ulcerative Colitis Richard S. Maser, Ph.D., Department of Medical Oncology Dana Farber Cancer Institute |
| Identification of the Muramyl Dipeptide Transporter in Phagocytes Required for NOD2 and NALP3 Activation Lynda Stuart, M.D., Ph.D., Pediatrics Massachusetts General Hospital |
Identification of Genes Regulating Epithelial Cell Renewal in the Adult Drosophila Intestine Craig A. Micchelli, Ph.D., Genetics Harvard Medical School |
| Rapid Membrane Remodeling During Phagosome Formation and Maturation Sergio Grinstein, Ph.D., The Hospital for Sick Children, Toronto, Canada |
Annual Workshop: November 10 - 11, 2006
The Phagosome and the Immune/Inflammatory Response
| Session I: Receptors Involved in Phagocytosis | |
| Fc Receptors and Phagocytosis Jeffrey Ravetch, M.D., Ph.D., Rockefeller University, New York, NY |
Not Only Tolls: Innate Recognition by Macrophage Receptors Siamon Gordon, M.B., Ch.B., Ph.D., University of Oxford, Oxford, UK |
| Phagocytosis of Bacterial Pathogens in Drosophila Christine Kocks, Ph.D., Massachusetts General Hospital, Boston, MA |
CD11b/CD18 (CR3) Signaling and Neutrophil Cytotoxicity Tanya Mayadas, Ph.D., Brigham and Women's Hospital, Boston, MA |
| Session II: Phagosome / Endosome Maturation | |
| A Systems Approach to Dissecting Immunity Alan Aderem, Ph.D., The Institute for Systems Biology, Seattle, WA |
Phagosomes and Cross Presentation in Dendritic Cells Sebastian Amigorena, Ph.D., Institut Curie, Paris, France |
| A Systems Biology Analysis of the Drosophila Phagosome Lynda Stuart, M.D., Ph.D., Massachusetts General Hospital, Boston, MA |
Mechanisms of Cross-Presentation Peter Cresswell, Ph.D., Yale University School of Medicine, New Haven, CT |
| Session III: Killing Mechanisms/NADPH Oxidase | |
| Regulation of NADPH Oxidase Activity in the Developing and in the Mature Neutrophil Dirk Roos, Ph.D., Sanquin Research at CLB and Landsteiner Laboratory, Amsterdam, The Netherlands |
NADPH Oxidase and Pi3K Michael Yaffe, M.D., Ph.D., Massachusetts Institute of Technology, Cambridge, MA |
| Regulation of NADPH Oxidase Function by SLAM Family Receptors Cox Terhorst, Ph.D., Beth Israel Deaconess Medical Center, Boston, MA |
How Neutrophils Kill Microbes Anthony Segal, M.D., Ph.D., University College London, UK |
| Role of Rac in Regulation of Noxl-3 Hideki Sumimoto, M.D., Ph.D., Kyushu University, Japan |
|
| Session IV: Intestinal Phagocytes | |
| Profound Inflammatory Anergy of Intestinal Macrophages Phillip Smith, M.D., The University of Alabama at Birmingham, Birmingham, AL |
Microbial Uptake in Gut Hans Christian Reinecker, M.D., Massachusetts General Hospital, Boston, MA |
| Survival and Replication of Crohn's Disease-Associated E. Coli Within Macrophages Arlette Darfeuille-Michaud, Ph.D., Université Auvergne , Clermont-Ferrand, France |
|
| Session V: Microbes, Phagosomes and Endosomes | |
| Salmonella Invasion of Host Cells Sergio Grinstein, Ph.D., The Hospital for Sick Children, Toronto, Canada |
Viral Entry Into Endosomes Ari Helenius, Ph.D., Institut f. Biochemie, Zurich, Switzerland |
| The Phagosomal Environment and Microbial Fitness David G. Russell, Ph.D., Cornell University, Ithaca, NY |
The Tyrosine Kinase Hck is Involved in Phagolysosome Biogenesis and Cell Migration Isabel Maridonneau-Parini, Ph.D., Institut de Pharmacologie et de Biologie Structurale, Toulouse, France |
| Phagocytosis: At the Crossroads of Innate and Adaptive Immunity Michel Desjardins, Ph.D., Université de Montréal, Canada |
|
| Session VI: Uptake of Apoptotic Cells by DC | |
| Engulfment of Apoptotic Cells and Nuclei Expelled from Erythroid Precursors, and its Defect Shigekazu Nagata, Ph.D., Osaka University Medical School, Osaka, Japan |
Recognition and Engulfment of Apoptotic Cells Simon Brown, Ph.D., The University of Edinburgh, UK |
| Phagocytosis of Apoptotic Neutrophils Regulates Granulopoiesis via IL-23 and IL-17 Klaus Ley, M.D., University of Virginia Health, Charlottesville, VA |
The Apoptotic Cell Receptor CR3 and Dendritic Cell Function Nina Bhardwaj, M.D., Ph.D., New York University Medical Center, New York, NY |
15th Annual Symposium
Thursday, November 10, 2005
| Age-dependent Changes in Intestinal Gene Expression Modulate the Immune Response to Enteric
Salmonella Infection Bobby J. Cherayil, M.D. Pediatric Gastrointestinal Unit Massachusetts General Hospital |
Are Beta2 Integrins Ready to Dance with Anthrax? Jian-Ping Xiong, Ph.D. Renal Unit Massachusetts General Hospital |
| The CD200 Receptor Regulates Mucosal Injury and Signaling by TLR4 Roy Soberman, M.D. Renal Unit Massachusetts General Hospital |
Dependence of Intestinal Granulomatous Inflammation on Macrophage-like Dendritic Cells Ken Sugimoto, M.D., Ph.D. Immunopathology Unit Massachusetts General Hospital |
| Glycosylation is Important in Bacterial-Epithelial Cross Talk During the
Establishment of Microbial Ecosystem in the Mammalian Gut N. Nanda Nanthakumar, M.D. Pediatric GI Massachusetts General Hospital |
Induction of NADPH Oxidase by the Cell Surface Receptor SLAM and the MyD88 Adapter Protein: Parallel or Serial Pathways? F. Stephen Laroux, Ph.D. Division of Immunology Beth Israel Deaconess Medical Center |
| The Role for LIGHT and TL1A in Th1 Mediated Mucosal Inflammation Stephan Targan, M.D. Cedars Sinai Medical Center Los Angeles, CA |
Annual Workshop: November 11 - 12, 2005
Immunological Memory
Friday, November 11, 2005
| SESSION I: T Cell Memory | |
| Memory CD8 T Cell Differentiation Rafi Ahmed, Ph.D. Emory University School of Medicine, Atlanta, GA |
Vitamins for Memory Hilde Cheroutre, Ph.D. La Jolla Institute for Allergy and Immunology San Diego, CA |
| Private Specificities of Heterologous Immunity Raymond Welsh, Ph.D. University of Massachusetts Medical Center Worcester, MA |
Private Specificities of Heterologous Immunity Raymond Welsh, Ph.D. University of Massachusetts Medical Center Worcester, MA |
| Antigen Presentation by Immature DC Generates Central Memory Cells With Robust Expansion
Potential Following Secondary Stimulation With Mature DC Cornelis Melief, Ph.D. Leiden University Medical Center Leiden, The Netherlands |
Cytokines and CD8+ Memory Cells Jonathan Sprent, M.D., Ph.D., The Scripps Research Institute, La Jolla, CA |
| SESSION II: T Cell Memory | |
| Cytokines and CD8+ Memory Cells Jonathan Sprent, M.D., Ph.D., The Scripps Research Institute, La Jolla, CA |
Homeostatic Mechanisms of Memory T Cell Generation Stephen Jameson, Ph.D., University of Minnesota, Minneapolis, MN |
| CD4 Memory Subsets: Generation, Maintenance and Function Susan Swain, Ph.D., Trudeau Institute, Inc., Saranac Lake, NY |
Memory CD4+ T Cells in a Chronic Disease: Studies With Leishmania Major Phillip Scott, Ph.D., University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA |
| SESSION III: B Cell and Plasma Cell Memory | |
| B Cell and Plasma Cell Memory Antonio Lanzavecchia, M.D., Institute for Research in Biomedicine Bellinzona, Switzerland |
A New Look at Human Memory B Cells Jean Claude Weill, Ph.D., INSERM, Paris, France |
| Regulation of Autoreactive Memory B Cell Formation Andrew Caton, Ph.D., The Wistar Institute Philadelphia, PA |
Antigen-Specific Memory B Cell Subsets Michael McHeyzer-Williams, Ph.D. The Scripps Research Institute La Jolla, CA |
| Memory B Cells in Mice Klaus Rajewsky, M.D. Harvard Medical School Boston, MA |
|
| SESSION IV: Memory and Recruitment | |
| Generation of Gut Tropic T Cells by Intestinal Dendritic Cells William Agace, Ph.D. Lund University Sweden |
In Situ Analysis of Effector/Memory T Cell Migration and Function Ulrich von Andrian, M.D. Harvard Medical School Boston, MA |
| Development of Memory T Cell Subsets Leo Lefrancois, Ph.D. University of Connecticut Farmington, CT |
Chemokine Control of Effector/Memory T Cell Entry and Exit in Periphery Tissue Andrew Luster, M.D., Ph.D. Massachusetts General Hospital Boston, MA |
| SESSION V: Memory and Inflammation | |
| Mucosal Specific Mechanisms of IFN Gamma Regulation Stephan Targan, M.D. Cedars Sinai Medical Center Los Angeles, CA |
Crosstalk of Mucosal Microbiota With Systemic iNKT and CD4+ T Cell Populations Jonathan Braun, M.D., Ph.D. University of California Los Angeles, CA |
| The Role of L-Selectin and PSGL-1 in Inflammatory Bowel Disease Klaus Ley, M.D. University of Virginia Health System Charlottesville, VA |
T Cell Cytokine Signaling and Apoptosis Markus Neurath, M.D., Ph.D. University of Mainz Germany |
14th Annual Symposium
Thursday, November 11, 2004
Thursday, November 11, 2004
| Examining Dynamics of Dynamin-Auxilin Interactions in Live Cells Sanja Sever, Ph.D., Renal Unit, Massachusetts General Hospital, Boston, Massachusetts |
Protein Tyrosine Phosphatases in GI Inflammation and Cancer Frank David, M.D., Ph.D., Cancer Biology |
| Benjamin Neel, M.D., Ph.D., Cancer Biology Beth Israel Deaconess Medical Center, Boston, Massachusetts |
Linking IBD and Cancer Through Cables Lawrence Zukerberg, M.D., Pathology Department, Massachusetts General Hospital, Boston, Massachusetts |
| Cross-Regulation Between TGF-beta and Galpha i2 Signaling Pathways Mei Wu, M.D., Ph.D., Dermatology Department, Massachusetts General Hospital, Boston, Massachusetts |
Postgenomic Screens in Yeast Provide New Insights into Shigella Pathogenesis Cammie Lesser, M.D., Ph.D., Infectious Disease, Massachusetts General Hospital, Boston, Massachusetts |
| Chitinase 3-Like-1 Exacerbates Intestinal Inflammation by Enhancing Bacterial Adhesion and Invasion in Colonic Epithelial Cells Emiko Mizoguchi, M.D., Ph.D., Gastrointestinal Unit, Massachusetts General Hospital, Boston, Massachusetts |
Inventing and Re-Inventing the GI Tract -Stem Cells, Development and Differentiation
Annual Workshop: November 12 - 13, 2004
| SESSION I: Development I: Organogenesis and Morphogenesis | |
| GI Organogenesis - Lessons From Xenopus Aaron Zorn, Ph.D., Cincinnati Children's Hospital Medical Center, Cincinnati, OH |
Developmental Patterning of the Gut in C. Elegans Helen Chamberlin, Ph.D., Ohio State University, Columbus, OH |
| Transcription Factor Control of Gastrointestinal Development Ramesh Shivdasani, M.D., Ph.D., Dana Farber Cancer Institute, Boston, MA |
Notch Signaling Endoderm Development - Lessons From Zebrafish Didier Stainier, Ph.D., University of California, San Francisco, CA |
| Regulation of Intestinal Fate by Notch in the Embryo and the Adult Ben Stanger, M.D., Ph.D., Massachusetts General Hospital, Boston, MA |
Molecular Regulation of Endocrine Pancreas Development James Wells, Ph.D., Cincinnati Children's Hospital Medical Center, Cincinnati, OH |
| Endocrine Cell Fate Specification in the GI Tract Gerard Gradwohl, Ph.D., INSERM, Strasbourg, France |
|
| SESSION II: Differentiation | |
| Molecular Pathways of Glucocorticoid Action on the Developing Intestine Susan Henning, Ph.D., Baylor College of Medicine, Houston, TX |
Extracellular-Matrix Molecules Signal Intestinal Morphogenesis and Differentiation Patricia Simon-Assmann, Ph.D., INSERM, Strasbourg, France |
| Epithelial Mesenchymal Interaction in Intestinal Morphogenesis Deborah Rubin, M.D., Washington University School of Medicine, St. Louis, MO |
Fork Head Protein and Transcriptional Regulation of GI Differentiation Klaus Kaestner, Ph.D., University of Pennsylvania Medical Center, Philadelphia, PA |
| NPO and Intestinal Differentiation in Zebrafish Allan Mayer, M.D., Ph.D., Medical College of Wisconsin, Milwaukee, WI |
Molecular Basis of the Intestinal Epithelium Differentiation - The Role of HMG-Box Transcription Factors Philippe Jay, Ph.D., Institut de Genetique Humaine, France |
| SESSION III: Stem Cells | |
| Thymic Origin of Intestinal Alphabeta T Cells Revealed by Fate Mapping of RORgammat+ Cells Dan R. Littman, M.D., Ph.D. New York University Medical Center, New York, NY |
Intestinal T Cells Utilize Wnt/b-Catenin Signaling to Generate Potent Innate Immune Responses at the Epithelial Barrier Terence Barrett, M.D., Northwestern University Medical School, Chicago, IL |
| Clonal Analysis of Intestinal Epithelium Matthew Bjerknes, Ph.D., University of Toronto, Canada |
Stem Cell and BMP Signaling Linheng Li, Ph.D., Stowers Institute for Medical Research, Kansas City, MO |
| Stem Cells for Gene Delivery in the Gut Hiroshi Mashimo, M.D., Ph.D., Boston VA Medical Center, Boston, MA |
|
| SESSION IV: Regeneration/Repair | |
| Fibroblast Growth Factors and Intestinal Stem Cell Regeneration Steven M. Cohn, M.D., Ph.D., University of Virginia Health System, Charlottesville, VA |
Bone Marrow Stem Cells and GI Regeneration Mamoru Watanabe, M.D., Ph.D., Tokyo Medical and Dental University, Tokyo, Japan |
| Molecular Basis of Functional Adaptation in Intestine Marc Levin, M.D., Washington University School of Medicine, St. Louis, MO | Regulation of Intestinal Repair Daniel K. Podolsky, M.D., Massachusetts General Hospital, Boston, MA |
13th Annual Symposium
Thursday - November 13, 2003
Thursday - November 13, 2003
| Use of Non-Mammalian Models for the Study of Host/Pathogen Interactions Eleftherios E. Mylonakis, M.D., Infectious Disease Unit Massachusetts General Hospital, Boston, Massachusetts |
Signal Transduction Through NOD2 - Role of Downstream RIPs and Caspases Lewis C. Cantley, Ph.D., Division of Signal Transduction Derek W. Abbott, M.D., Ph.D., Division of Signal Transduction Beth Israel Deaconess Medical Center, Boston, Massachusetts |
| Roles of Matrix Metalloproteinases in the Experimental Inflammatory Bowel Disease that Accompanies Mucosal Injury in Mice Masaki Inada, D.D.S., Ph.D., Department of Medicine Massachusetts General Hospital, Boston, Massachusetts |
Signaling and the Cytoskeleton - Deciphering the Role of WASP Family Members in Microbial Pathogenesis and Epithelial Function Scott B. Snapper, M.D., Ph.D., Gastrointestinal Unit Anna Lyubimova, Ph.D., Gastrointestinal Unit Massachusetts General Hospital, Boston, Massachusetts |
| PKK - A Pleotropic Activator of NFkappaB Shiv S. Pillai, M.B.B.S., Ph.D., Cancer Center Massachusetts General Hospital, Boston, Massachusetts |
DOCK4 Signaling Pathway in Cancer Vijay Yajnik, M.D., Ph.D., Gastrointestinal Unit Massachusetts General Hospital, Boston, Massachusetts |
| Activation of a Selective CD8+ Regulatory T Cell by Intestinal Epithelial Cells Lloyd Mayer, M.D. The Mount Sinai Medical Center, New York, New York |
Immune Regulatory Networks
Annual Workshop: November 14 - 15, 2003
| SESSION I: Overview/Plenary | |
| The Spectrum of Treg Ethan Shevach, M.D., National Institutes of Health , Bethesda, MD |
CD4+ CD25+ Foxp3+ Regulatory T Cells Shimon Sakaguchi, M.D., Ph.D. Kyoto University, Kyoto, Japan |
| SESSION II: Development of Treg | |
| Thymic Development and Function - Tregs Andy Caton, Ph.D. Wistar Institute, Philadelphia, PA |
Diverse Origins and Phenotypes of Regulatory T Cells Harald von Boehmer, M.D., Ph.D. Harvard Medical School, Boston, MA |
| Scurfin and CD4+CD25+ T Reg
Fred Ramsdell, Ph.D. Celltech R&D Inc. Bothell, WA |
Foxp3 Programs the Development and Function of CD4+CD25+ Treg
Alexander Rudensky, Ph.D. University of Washington Seattle, WA |
| SESSION III: Mechanism(s) of Action and Trafficking of Treg | |
| Toll Pathways and Treg Ruslan Medzhitov, Ph.D., Yale University School of Medicine, New Haven, CT | T Cell Regulation and Homeostasis Birgitta Stockinger, M.D., The National Institute for Medical Research, London, UK |
| SESSION IV: Induction of Treg by Specialized Populations of DC | |
| DC That Induce Tolerance and Treg Differentiation In Vivo Herve Groux, Ph.D., Hôpital de l'Archet, Nice, France | Ligation on DC and Induction of Th2/Treg Anne O'Garra, Ph.D., The National Institute for Medical Research, London, UK |
| Plasmacytoid DC and Induction of Treg Yong-Jun Liu, Ph.D., University of Texas MD Anderson Cancer Center, Houston, TX |
Induction of Treg by Targeting Antigen to Immature DC Michel Nussenzweig, M.D., Ph.D., The Rockefeller University, New York, NY |
| ICOS-ICOS-Ligand Pathway and Treg Development Dale T. Umetsu, M.D., Ph.D., Stanford University, Stanford, CA |
Specialized Subpopulations of Mucosal DC Brian Kelsall, M.D., National Institutes of Health, Bethesda, MD |
| Treg Cells and TRANCE-RANK Signals Richard Flavell, Ph.D., Yale University School of Medicine, New Haven, CT |
|
| Session v : Suppression of Disease by Regulatory Cells | |
| Treg and EAE Jocelyn Demengeot, Ph.D., Instituto Gulbenkian de Ciência, Oeiras, Portugal |
CD4+ CD25+ Treg and Leishmania; Persistence and Immunity David Sacks, Ph.D., National Institutes of Health , Bethesda, MD |
| Antigen Induced Regulatory T Cells in Autoimmunity Matthias von Herrath, M.D., La Jolla Institute for Allergy and Immunology, La Jolla, CA |
Arthritis and Interleukin 10-Producing B Cells Marco Londei, M.D., University College London, London, UK |
| Regulatory B Cells in Chronic Colitis Atsushi Mizoguchi, M.D., Ph.D., Massachusetts General Hospital, Boston, MA |
|
| SESSION VI: Regulatory Cells and IBD (I) | |
| DCs and Tregs Regulating Airway Inflammation and IBD Anuradha Ray, Ph.D., University of Pittsburgh School of Medicine, Pittsburgh, PA |
Treg and the CD45RB Transfer Model Fiona Powrie, M.D., University of Oxford, London, UK |
| Treg, the Thymus and Colitis: GITR Ligands Cox Terhorst, Ph.D., Beth Israel Deaconess Medical Center, Boston, MA |
Treg Microbial Flora and Murine Colitis Charles Elson III, M.D., University of Alabama, Birmingham, AL |
| SESSION VII: Regulatory Cells and IBD (II) | |
| Activation of CD8+ Tregs by Intestinal Epithelial Cells
Lloyd Mayer, M.D. The Mount Sinai Medical Center, New York, NY |
Intestinal Dendritic Cells Hans-Christian Reinecker, M.D., Massachusetts General Hospital, Boston, MA |
| Treg and Th1/Th2 Models Warren Strober, M.D., National Institutes of Health , Bethesda, MD |
Lymphocyte Activation in the SAMP1/YitFc Model of Ileitis Fabio Cominelli, M.D., Ph.D. University of Virginia |
| ICOS Pathways Regulate Murine Colitis Mamoru Watanabe, M.D., Ph.D. Tokyo Medical and Dental University Tokyo, Japan |
|
12th Annual Symposium
Thursday - November 21, 2002
Thursday - November 21, 2002
| Nonhuman Primate Model for Colorectal Cancer Jae U. Jung, Ph.D., Division of Tumor Virology Harvard Medical School, Southborough, Massachusetts |
ESE-1, an Enterocyte-Specific ets Transcription Factor, Regulates MIP-3a Gene Expression in Colonic Epithelial Cells Andrew C Keates, Ph.D., Gastrointestinal Unit Beth Israel Deaconess Medical Center, Boston, Massachusetts |
| Molecular Interactions in Shigella Actin-Based Motility Marcia Goldberg, M.D., Infectious Disease Unit Massachusetts General Hospital, Boston, Massachusetts |
Small Intestinal Dendritic Cells in Mice With a Targeted Deletion of CX3CR1 and Green Fluorescence Protein Reporter Insertion Hans-Christian Reinecker, M.D., Gastrointestinal Unit Jan H. Niess, M.D., Gastrointestinal Unit Massachusetts General Hospital, Boston, Massachusetts |
| Visualization of MHC Class II Molecules in the Small Intestine Jatin Vyas, M.D., Ph.D., Infectious Disease Unit Massachusetts General Hospital, Boston, Massachusetts |
The Relationship Between the Thymus and T Regulatory Cells in Murine Models
of Colitis William A. Faubion, Jr., M.D., Gastrointestinal Unit Beth Israel Deaconess Medical Center, Boston, Massachusetts |
| The Role of the NF- k B/IkB Pathway in Substance P Receptor Gene Regulation Simos Simeonidis, Ph.D., Gastroenterology Division Beth Israel Deaconess Medical Center, Boston, Massachusetts |
Functional Interface Between Salmonella and the Host: Type III
Secretion at Work Jorge Galan, Ph.D. Yale University School Of Medicine New Haven, Connecticut |
Microbial - Mucosal Interactions
Annual Workshop: November 22 - 23, 2002
| SESSION I: The Flora | |
| The Gastrointestinal Ecosystem Robin G. Lorenz, M.D., Ph.D., University of Alabama at Birmingham, Birmingham, Alabama |
Influence of Gut Bacteria on Host Physiology Lora Hooper, Ph.D., Washington University School of Medicine, St. Louis, Missouri |
| The Mucosal Biofilm Alexander Swidsinski, M.D., Klinik Gastroenterology, Berlin, Germany | |
| SESSION II: Bacterial Pathogenesis | |
| Salmonella Signaling in the Host Jorge Galan, Ph.D., Yale University School of Medicine, New Haven, Connecticut |
Signaling Pathways During Yersinia Infection
Ralph Isberg, Ph.D., Tufts University, Boston, Massachusetts |
| Molecular Interactions of Yops With Host Cells James Bliska, Ph.D., State University of New York at Stony Brook, Stony Brook, New York |
Modulation of Tight Junctions by Shigella Beth McCormick, Ph.D., Massachusetts General Hospital, Boston, Massachusetts |
| Host Cytoskeletal - Pathogen Interactions Scott B. Snapper, M.D., Ph.D., Massachusetts General Hospital, Boston, Massachusetts |
|
| SESSION III: Epithelial Function and the Host Response to Microbes | |
| Bacterial-Epithelial Interactions Kim E. Barrett, Ph.D., UCSD Medical Center, San Diego, California |
Interactions of EPEC With Epithelial Cells Gail Hecht, M.D., University of Illinois, Chicago, Illinois |
| Epithelial Cell Responses to Gram-Negative Bacterial Infection Dana Philpott, M.D., Institut Pasteur, Paris, France |
Defensins and Microbial Infection Charles Bevins, M.D., Ph.D., The Cleveland Clinic Foundation, Cleveland, Ohio |
| SESSION IV: Innate Immune Response to Microbes (TLRs) | |
| TLRs and Bacterial Infection Douglas Golenbock, M.D., University of Massachusetts Medical Center, Worcester, Massachusetts |
Flagellin/TLR5 in Innate and Adaptive Mucosal Immunity Andrew Gewirtz, Ph.D., Emory University, Atlanta, Georgia |
| TLRs and Nods in Intestinal Mucosa Daniel K. Podolsky, M.D., Massachusetts General Hospital, Boston, Massachusetts |
Nod2 in Mice and Humans Gabriel Nunez, M.D., University of Michigan Medical School, Ann Arbor, Michigan |
| Session v : Mucosal Immune Regulatory Responses Induced by Enteric Microbes (I) | |
| Helicobacter and Gastrointestinal Immunity Peter Ernst, D.V.M., Ph.D., University of Virginia, Charlottesville, Virginia |
Gastrointestinal Response to Bacterial Infection David Schauer, D.V.M., Ph.D., Massachusetts Institute of Technology, Cambridge, Massachusetts |
| TLRs, G Coupled Receptors, and Innate B Cells in Microbial-Immune Homeostasis Jonathan Braun, M.D., Ph.D., UCLA Hospital, Los Angeles, California |
Influence of Luminal Flora on Allergic Responses to Food Cathryn Nagler, Ph.D., Massachusetts General Hospital, Boston, Massachusetts |
| SESSION VI: Mucosal Immune Regulatory Responses Induced by Enteric Microbes (II) | |
| Regulation of T cell Responses to Enteric Bacteria Charles Elson, Ph.D., University of Alabama at Birmingham, Birmingham, Alabama | Regulation of Response to Luminal Flora by IL-10 Balfor Sartor, M.D., University of North Carolina School of Medicine, Chapel Hill, North Carolina |
| Molecular Mechanisms Regulating Inflammatory Bowel Disease Warren Strober, M.D., National Institutes of Health, Bethesda, Maryland | |
| SESSION VII: The Luminal Flora and IBD | |
| Mucosal Inflammatory Responses by Enteric Microflora in Human IBD Toshifumi Hibi, M.D., Keio University Hospital, Tokyo, Japan | Adherent-Invasive Bacteria and IBD Arlette Darfeuille-Michaud, Ph.D., Univesite d'Auvergne, France |
| Molecular Intestinal Microbial Diversity (normal vs. IBD) Yingzi Cong, Ph.D., University of Alabama at Birmingham, Birmingham, Alabama | |
11th Annual Symposium
Thursday - November 15, 2001
Thursday - November 15, 2001
| Regulation of VEGF by the Wnt and K-ras Pathways in Colonic Epithelial Cells Daniel C. Chung, M.D., Gastrointestinal Unit Massachusetts General Hospital, Boston, Massachusetts |
Transcriptional Regulation of Tight Junction Associated Protein Expression in
Intestinal Epithelial Cells Hans-Christian Reinecker, M.D., Gastrointestinal Unit Massachusetts General Hospital, Boston, Massachusetts |
| Can the Chemokine TECK Activate TH1 and TH2 Cells in a CR9-Independent
Manner? Robert E. Gerszten, M.D., Cardiology Division Massachusetts General Hospital, Boston, Massachusetts |
Role of Intestinal Epithelial Cell-Derived Galectin-4 as a Pathogenic Mediator in Chronic Colitis Atsushi Mizoguchi, M.D., Immunopathology Massachusetts General Hospital, Boston, Massachusetts |
| Shiga Toxin Production and Lysis Gene Expression During Cellular Invasion by
Shigella Dysenteriae 1 Joan Butterton, M.D., Infectious Disease Unit Massachusetts General Hospital, Boston, Massachusetts |
The Induction of Intestinal Inflammation: Role of Luminal Bacterial Antigen Haining Shi, Ph.D., Mucosal Immunology Massachusetts General Hospital, Boston, Massachusetts |
| Signaling and the Cytoskeleton in Mammalian Cells: Lessons Learned from
Microbes that Move Marcia Goldberg, M.D., Infectious Disease Unit Massachusetts General Hospital, Boston, Massachusetts |
Role of NF- k B in Neuropeptide-Mediated Intestinal Inflammation Charalabos Pothoulakis, M.D., Gastrointesinal Division Beth Israel Deaconess Medical Center, Boston, Massachusetts |
| Nod2 and Crohn's Disease Gabriel Nunez, M.D. University of Michigan Medical School, Ann Arbor, Michigan |
NF- k B IN HOST DEFENSE: GENETICS, BIOCHEMISTRY AND FUNCTION
Annual Workshop: November 16 - 17, 2001
| SESSION I: MECHANISMS OF NF- kB ACTIVATION | |
| Ras like GTPases in the Regulation of NF- k B Sankar Ghosh, Ph.D., Yale University, New Haven, CT |
Regulation of NF- k B Action by Reversible Acetylation Warner C. Greene, M.D., Ph.D., University of California, San Francisco, CA |
| Regulation of NF- k B IkappB by Lysosome Function Ana Maria Cuervo, M.D., Ph.D., Tufts University School of Medicine, Boston, MA | |
| SESSION II: FUNCTIONAL DISSECTION OF NF- k B ACTIVATION PATHWAYS | |
| Expression Profiling of NF- k B Pathways Carter Van Waes, M.D., Ph.D., National Institute on Deafness and Other Communication Disorders, Bethesda, MD |
Functional Consequences of Conditional Targeting of NEMO and IKK Mark Schmidt-Supprian , M.D., Center for Blood Research, Inc., Boston, MA |
| A20-/- in Regulating NF- k B Function
Averil Ma, M.D., University of Chicago, Chicago, IL |
The Role of IKK in IBD Florian Greten, M.D., University of California, San Diego, CA |
| SESSION III: NF- k B IN THE REGULATION OF INFLAMMATORY, ANTIAPOPTOTIC, AND IMMUNE RESPONSES | |
| NF- k B and Human Genetic Pathologies Alain Israel, M.D., Institut Pasteur, France |
NF- k B Transcription Factors in Cancer Thomas D. Gilmore, Ph.D., Boston University, Boston, MA |
| NF- k B in the Regulation of Chemokines Andrew Luster, M.D., Ph.D., Massachusetts General Hospital, Boston, MA |
NF- k B in T-cell Development and Function Ramnik Xavier, M.D., Massachusetts General Hospital, Boston, MA |
| NF- k B in B-cell Development and Function Shiv Pillai, M.D., Ph.D., Massachusetts General Hospital, Boston, MA |
Mechanisms of T-cell Development and Function Terence Barrett, M.D., Northwestern University Medical School, Chicago, IL |
| Modulation of Proinflammatory and Apoptotic Signaling Cascade by Cellular
Differentiation in Intestinal Epithelial Cells Christian Jobin, Ph.D., University of North Carolina at Chapel Hill, Chapel Hill, NC |
|
| Session iv . NF- k B IN THE RECOGNITION OF PATHOGENS AND INTESTINAL INFLAMMATION | |
| Activation of NF- k B by Intracellular LPS Receptor Nod1/2 Gabriel Nunez, M.D., University of Michigan Medical School, Ann Arbor, MI |
Intracellular NF- k B Activation by Shigella Flexneri Philippe J. Sansonetti, M.D., Institut Pasteur, FRANCE |
| Prokaryotic Inhibition of NF- k B Activation in Epithelial Cells James L. Madara, M.D., Emory University School of Medicine, Atlanta, GA |
Typhlocolitis in NF- k B-Deficient Mice Bruce H. Horwitz, M.D., Ph.D., Brigham and Women's Hospital, Boston, MA |
| NF- k B and Ubiquitin in IBD Toshifumi Hibi, M.D., Keio University School of Medicine, Tokyo, Japan |
|
| SESSION V. NF- k B AS TARGET FOR NOVEL THERAPEUTICS | |
| Cellular Targets for Inhibiting the NF- k B Pathway Richard B. Gaynor, M.D., University of Texas Southwestern Medical Center, Dallas, TX |
Phosphorothioate Oligonucleotides in the Inhibition of NF- k B Warren Strober, M.D., National Institutes of Health, Bethesda, MD |
| Inhibitors of NF- k B Nuclear Localization Steven G. Nadler, Ph.D., Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, NJ |
Approaches to NF- k B Inhibition Yajun Xu, Ph.D., Millennium Pharmaceutical, Cambridge, MA |
