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Consider your preliminary study design: What is your hypothesis? How can you improve it?


  • Excellent research begins with a clear hypothesis which can be either supported or rejected through the generation and analysis of new data collected via the conduct of clinical research.
  • These data should be subjected to statistical analysis, and the results should either confirm or reject the original hypothesis.
  • To create a strong hypothesis, start with a good research question -- one for which the answer will matter to other researchers in the field, practicing clinicians, or patients.
  • Convert your research question to hypothesis by asserting a position. This will lead directly to a consideration of measures, both of exposure and outcome.
  • The null hypothesis is a statement a researcher wants to test. In general, the null hypothesis is the same as a theoretical expectation. Analysis is performed to reject or accept the null hypothesis.


Consultation with Clinical Research Program (CRP) Faculty


Harvard X's Fundamentals of Clinical Trials

Design and Conduct of Clinical Trials

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