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Principal Investigator Mohammed Milad, M.D., Psychiatry
Influence of Gonadal Hormones on Fear Extinction
We will use functional MRI and psychophysiological measures to examine the influence of sex and gonadal hormones on brain regions involved in extinction recall. Two hypotheses will be tested: 1) elevated estrogen levels during menstrual cycle will attenuate activity of the extinction circuit, and thus extinction capacity will be reduced, and 2) administration of progesterone will facilitate functional activity of this extinction circuitry during extinction recall that will result in enhanced extinction capacity.

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