Mass General Home

676

Principal Investigator Braden Kuo, M.D., Psychiatry
Title
Defining Central Circuits of Visceral Pain
Abstract
The purpose of our proposed project is: to measure fMRI signal in primary visceral pain pathways in normal human subjects and in patients with dyspepsia following instilling a liquid meal at a fixed rate into the stomach until maximal satiety, a surrogate model of dyspepsia; to measure fMRI signal in autonomic pathways and in endogenous analgesic pathways in normal human subjects and in patients with dyspepsia using the above model; and to correlate physiological parameters (heart rate, skin conductance, respiratory rate) to hedonic ratings (ratings on a visual analogue scale of satiety, nausea, bloating, and pain) during the liquid meal stimulus in normal human subjects and patients with dyspepsia.

Key Personnel