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Principal Investigator Jill Goldstein , M.D., Psychiatry
Title
fMRI of Sex Effects, Affect and Hormones in Schizophrenia
Abstract
This is a study of the impact of gonadal and adrenal hormones on affective arousal in schizophrenia as compared to normal control individuals and adult offspring at risk for schizophrenia. Psychophysiological indicators of arousal (heart rate and galvanic skin response) are collected during fMRI scanning to validate arousal states as is blood, in order to assess relationships between hormonal changes and brain activations. Hypotheses regarding the impact of hormones are focused on brain regions that are normally sexually dimorphic and implicated in affective processing (i.e. amygdala, insula, cingulate gyrus, and frontoorbital cortex (FOC)). We predict disrupted activations in these regions in schizophrenia and in high risk offspring, which we predict will be related to disruptions in gonadal and adrenal hormones.

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