MGH Center for Chordoma Care





Edwin Choy, MD, PhD Telephone 617-724-4000 Office Address Massachusetts General Hospital Cancer Center 55 Fruit Street, Yawkey 7B Boston, MA 02114 Clinical Address Massachusetts General Hospital Cancer Center Ctr. for Sarcoma & Connective Tissue Oncology 55 Fruit Street, Yawkey 3 Boston, MA 02114

Orthopaedic Oncology Francis Hornicek, MD, PhD Director & Surgeon Frank X. Pedlow, Jr. MD Surgeon Kevin Raskin, MD Surgeon Joseph Schwab, MD Surgeon Dempsey Springfield, MD Surgeon Nursing Al Ferreira, RN Nurse Coordinator Anne Fiore, NP Nurse Practitioner Radiation Oncology Yen-Lin Chen, MD Radiation Oncologist Thomas DeLaney, MD Radiation Oncologist Norbert Liebsch, MD, PhD Radiation Oncologist Medical Oncology Edwin Choy, MD, PhD Medical Oncologist David Harmon, MD Medical Oncologist Scott Plotkin, MD, PhD Medical Oncologist Judianne Henderson, NP Nurse Practitioner NeuroSurgery Frederick Barker, MD Neurosurgeon Lawrence Borges, MD Neurosurgeon William Curry, MD Neurosurgeon Plastic Surgery William Gerald Austen, MD Plastic Surgeon Eric Liao, MD, PhD Plastic Surgeon Radiology Susan Kattapuram, MD Radiologist Daniel Rosenthal, MD Radiologist Pathology G. Petur Nielsen, MD Pathologist Andrew Rosenberg, MD Pathologist ENT Stacey Gray, MD Otolaryngologist Eric Holbrook, MD ENT Surgeon Derrick Lin, MD ENT Surgeon James Rocco, MD, PhD ENT Surgeon Research Francis Hornicek, MD, PhD Co-Director Ramnik Xavier, MD Co-Director Zhenfeng Duan, MD, PhD Joseph Schwab, MD Surgeon Click here for the Contact Us page		“To manage a disease as rare and challenging as chordoma, you need a high volume chordoma center where world leaders in chordoma biology, surgery, radiation, pathology, radiology and nursing can all work closely together in a seamless fashion. MGH has exactly such a center.” Edwin Choy MD, PhD Clinical Address Massachusetts General Hospital Cancer Center Center for Sarcoma and Connective Tissue Oncology 55 Fruit Street, YAW 3 Boston, MA 02114 Clinical Interests Sarcoma and Connective Tissue Oncology Education MD Degree: New York University School of Medicine, NY, 2000 PhD Degree: New York University School of Medicine, NY, 1999 Postdoctoral Training Residency: Internal Medicine, Massachusetts General Hospital, Boston, MA Fellowship: Hematology and Oncology, Dana-Farber Cancer/Partners CancerCare, Boston, MA Postdoctoral Research Fellowship: Medical and Population Genetics, Broad Institute of MIT and Harvard University, Cambridge, MA Board Certification Internal Medicine Medical Oncology Hospital Appointments Attending, Hematology & Medical Oncology Director of Sarcoma Research Massachusetts General Hospital Academic Appointments Instructor in Medicine, Harvard Medical School Publications Duan, Z., Choy, E., Harmon, D., Yang, C., Ryu, K., Schwab, J., Mankin, H., and Hornicek, F. (2009) “Insulin-like growth factor-I receptor tyrosine kinase inhibitor cyclolignan picrophodophyllin inhibits proliferation and induces apoptosis in multidrug resistant osteosarcoma cell lines.” Mol. Cancer Ther., In Press. Choy, E., Digumarthy, S., and Koplin, S. (2009) "A 23 year old man with cough, hoarseness, and fever." Case Records of the Massachusetts General Hospital, New Engl J Med. In Production. Duan, Z., Choy, E., Harmon, D., Yang, C., Ryu, K., Schwab, J., Galmarini, C., Del Maria, C., Mankin, H., and Hornicek, F.J. “ZNF93 Increases Resistance to ET-743 (Trabectedin; Yondelis®) and PM00104 (Zalypsis®) in Human Cancer Cell lines. PLOS ONE, In press. Duan, Z., Choy, E., Jimeno, J.M., del Maria Cuevas, C., Mankin, H.J., and Hornicek, F.J. (2009) “Diverse cross-resistance phenotype to ET-743 and PM00104 in multi-drug resistant cell lines selected in vitro using paclitaxel, doxorubicin or cisplatin.” Cancer Chemotherapy and Pharmacology, 63(6):1121-9. Yang, C., Schwab, J., Schoenfeld, A., Hornicek, F., Wood, K., Nielsen, G., Choy, E., Mankin, H., and Duan, Z. (2009) “A Novel Target for Treatment of Chordoma: Stat3.” Mol Canc Ther, In press. Yang C, Hornicek FJ, Wood KB, Schwab JH, Choy E, Iafrate J, Rosenberg A, Nielsen P, Xavier R,Mankin H, and Duan Z. (2009) “Characterization and Analysis of Human Chordoma Cell Lines.” Spine. In press. De Jager, P., Baecher-Allan, C., Maier, L.M., McCauley, J.L., Sawcer, S., Goris, A., Yelensky, R., Price, N., Patterson, N., de Bakker, P., Tran,m D., Aubin, C., Pobywajlo, S., Rossin, E., Choy, E., et al. (2009) “The role of the CD58 locus in multiple sclerosis.” Proc Nat Acad Sci, 106(13):5264-9. Schwab J, Antonescu C, Boland P, Healey J, Rosenberg A, Nielsen P, Iafrate J, Delaney T, Yoon S, Choy E, et al. (2009) “Combination of PICK/mTOR Inhibition Demonstrates Efficacy in Human Chordoma.” Anticancer Res. 29(6):1867-71. Maduekwe UN, Hornicek FJ, Springfield DS, Raskin KA, Harmon DC, Choy E, et al. (2009) “Role of sentinel lymph node biopsy in the staging of synovial, epithelioid, and clear cell sarcomas. Ann Surg Oncol. 16(5):1356-63. Choy, E., Yelensky, R., Bonakdar, S., et al. (2008) “Genetic Analysis of Human Traits In-Vitro: Drug Response and Gene Expression in Lymphoblastoid Cell Lines.” PLOS Genetics, 4(11):e1000287. equally contributing first-authors Duan, Z., Weinstein, E., Ji, D., Ames, R., Choy, E., et al. (2008) “Lentiviral shRNA screen of multidrug resistant associated genes identifies PRP-4 as a new regulator of chemoresistance in human ovarian cancer.” Mol. Cancer Ther., 8:2377-85. Reich, D., Patterson, N., Ramesh, V., De Jager, P.L., McDonald G.V., Tandon, A., Choy, E., et al. (2007) “Admixture mapping of an allele affecting serum IL6 and IL6 receptor levels.” American Journal of Human Genetics* 80(4):716-26. Choy, E. and Philips, M.R. (2001) “Green fluorescent protein-tagged Ras proteins for intracellular localization.” Methods in Enzymology 332, 50-64. Choy, E. and Philips, M.R. (2000) “Expression and activity of a prenylcysteine-directed carboxyl methyltransferase.” Methods in Enzymology 325, 101-114. Choy, E., Chiu, V.K., Silletti, J., Feoktistov, M., Morimoto, T., Michaelson, D., Ivanov, I.E., and Philips, M.R. (1999) “Endomembrane Trafficking of Ras: the CAAX Motif Targets Proteins to the ER and Golgi.” Cell 98, 69-80. Dai, Q., Choy, E., Chiu, V., Romano, J., Slivka, S.R., Steitz, S.A., Michaelis, S., and Philips, M.R. (1998) “Mammalian Prenylcysteine Prenyltransferase is in the Endoplasmic Reticulum.” Journal of Biological Chemistry 273(24), 15030-15034. Click here for PubMed listings for Dr. Choy Dr. Choy specializes in the treatment of sarcoma and chordoma at the MGH Cancer Center and the Harris Center for Chordoma Care. Sarcomas are rare malignant tumors derived from connective tissue. Although a substantial group of sarcomas are characterized by a defined chromosomal translocations, the molecular basis for most subtypes of sarcomas is unknown. In collaboration with other investigators at The Massachusetts General Hospital, The Dana-Farber Cancer Institute, and The Broad Institute, he utilizes high-throughput genotyping technology to understand the molecular basis of sarcomas in order to gain insight into novel therapeutic options for patients who would otherwise have no treatment alternatives. In addition to this translational approach, his clinical research team collaborates closely with the sarcoma team at Dana-Farber in testing novel agents in a patient population in a phase I, II, or III setting. His team is currently enrolling patients onto clinical trials perturbing the IGF1R, mTor, src, DR5, VEGF, c-met, and hsp-90 pathways.
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