Edwin Choy, MD, PhD

Telephone
617-724-4000

Office Address
Massachusetts General Hospital Cancer Center
55 Fruit Street, Yawkey 7B
Boston, MA 02114


Clinical Address
Massachusetts General Hospital Cancer Center
Ctr. for Sarcoma & Connective Tissue Oncology
55 Fruit Street, Yawkey 3
Boston, MA 02114

 
         



Orthopaedic Oncology
Francis Hornicek, MD, PhD Director & Surgeon
Frank X. Pedlow, Jr. MD Surgeon
Kevin Raskin, MD Surgeon
Joseph Schwab, MD Surgeon

Nursing
Al Ferreira, RN Nurse Coordinator
Anne Fiore, NP Nurse Practitioner

Radiation Oncology
Yen-Lin Chen, MD Radiation Oncologist
Thomas DeLaney, MD Radiation Oncologist
Norbert Liebsch, MD, PhD Radiation Oncologist

Medical Oncology
Edwin Choy, MD, PhD Medical Oncologist
David Harmon, MD Medical Oncologist
Scott Plotkin, MD, PhD Medical Oncologist
Gregory Cote, MD Medical Oncologist
Judianne Henderson, NP Nurse Practitioner

NeuroSurgery
Frederick Barker, MD Neurosurgeon
Lawrence Borges, MD Neurosurgeon
William Curry, MD Neurosurgeon

Surgical Oncology
John Mullen, MD Surgeon


Plastic Surgery
William Gerald Austen, MD Plastic Surgeon
Eric Liao, MD, PhD Plastic Surgeon

Radiology
Susan Kattapuram, MD Radiologist
Daniel Rosenthal, MD Radiologist

Pathology
G. Petur Nielsen, MD Pathologist

ENT
Stacey Gray, MD Otolaryngologist
Eric Holbrook, MD ENT Surgeon
Derrick Lin, MD ENT Surgeon
James Rocco, MD, PhD ENT Surgeon
Benjamin S. Bleier, M.D. ENT Surgeon

Research
Francis Hornicek, MD, PhD Co-Director
Ramnik Xavier, MD Co-Director
Zhenfeng Duan, MD, PhD
Joseph Schwab, MD Surgeon

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“To manage a disease as rare and challenging as chordoma, you need a high volume chordoma center where world leaders in chordoma biology, surgery, radiation, pathology, radiology and nursing can all work closely together in a seamless fashion. MGH has exactly such a center.”  


Edwin Choy MD, PhD

 

Clinical Address
Massachusetts General Hospital Cancer Center
Center for Sarcoma and Connective Tissue Oncology
55 Fruit Street, YAW 3
Boston, MA 02114

Clinical Interests
Sarcoma and Connective Tissue Oncology

Education
MD Degree: New York University School of Medicine, NY, 2000
PhD Degree: New York University School of Medicine, NY, 1999

Postdoctoral Training
Residency: Internal Medicine, Massachusetts General Hospital, Boston, MA
Fellowship: Hematology and Oncology, Dana-Farber Cancer/Partners CancerCare, Boston, MA
Postdoctoral Research Fellowship: Medical and Population Genetics, Broad Institute of MIT and Harvard University, Cambridge, MA

Board Certification
Internal Medicine
Medical Oncology

Hospital Appointments
Attending, Hematology & Medical Oncology
Director of Sarcoma Research
Massachusetts General Hospital

Academic Appointments
Assistant Professor, Harvard Medical School

Publications
Duan, Z.*, Choy, E.*, Harmon, D., Yang, C., Ryu, K., Schwab, J., Mankin, H., and Hornicek, F. (2009) “Insulin-like growth factor-I receptor tyrosine kinase inhibitor cyclolignan picrophodophyllin inhibits proliferation and induces apoptosis in multidrug resistant osteosarcoma cell lines.” Mol. Cancer Ther., In Press. 

Choy, E., Digumarthy, S., and Koplin, S. (2009) "A 23 year old man with cough, hoarseness, and fever." Case Records of the Massachusetts General Hospital, New Engl J Med. In Production.

Duan, Z., Choy, E., Harmon, D., Yang, C., Ryu, K., Schwab, J., Galmarini, C., Del Maria, C., Mankin, H., and Hornicek, F.J. “ZNF93 Increases Resistance to ET-743 (Trabectedin; Yondelis®) and PM00104 (Zalypsis®) in Human Cancer Cell lines. PLOS ONE, In press.

Duan, Z., Choy, E., Jimeno, J.M., del Maria Cuevas, C., Mankin, H.J., and Hornicek, F.J. (2009) “Diverse cross-resistance phenotype to ET-743 and PM00104 in multi-drug resistant cell lines selected in vitro using paclitaxel, doxorubicin or cisplatin.” Cancer Chemotherapy and Pharmacology, 63(6):1121-9.

Yang, C., Schwab, J., Schoenfeld, A., Hornicek, F., Wood, K., Nielsen, G., Choy, E., Mankin, H., and Duan, Z. (2009) “A Novel Target for Treatment of Chordoma: Stat3.” Mol Canc Ther, In press.

Yang C, Hornicek FJ, Wood KB, Schwab JH,  Choy E, Iafrate J, Rosenberg A, Nielsen P, Xavier R,Mankin H, and  Duan Z. (2009) “Characterization and Analysis of Human Chordoma Cell Lines.” Spine. In press.

De Jager, P., Baecher-Allan, C., Maier, L.M., McCauley, J.L., Sawcer, S., Goris, A., Yelensky, R., Price, N., Patterson, N., de Bakker, P., Tran,m D., Aubin, C., Pobywajlo, S., Rossin, E., Choy, E., et al. (2009)  “The role of the CD58 locus in multiple sclerosis.” Proc Nat Acad Sci, 106(13):5264-9.

Schwab J, Antonescu C, Boland P, Healey J, Rosenberg A, Nielsen P, Iafrate J, Delaney T, Yoon S, Choy E, et al. (2009) “Combination of PICK/mTOR Inhibition Demonstrates Efficacy in Human Chordoma.” Anticancer Res. 29(6):1867-71.

Maduekwe UN, Hornicek FJ, Springfield DS, Raskin KA, Harmon DC, Choy E, et al. (2009) “Role of sentinel lymph node biopsy in the staging of synovial, epithelioid, and clear cell sarcomas. Ann Surg Oncol. 16(5):1356-63.

Choy, E.*, Yelensky, R.*, Bonakdar, S., et al. (2008) “Genetic Analysis of Human Traits In-Vitro: Drug Response and Gene Expression in Lymphoblastoid Cell Lines.” PLOS Genetics, 4(11):e1000287. *equally contributing first-authors

Duan, Z., Weinstein, E., Ji, D., Ames, R., Choy, E., et al.  (2008) “Lentiviral shRNA screen of multidrug resistant associated genes identifies PRP-4 as a new regulator of chemoresistance in human ovarian cancer.” Mol. Cancer Ther., 8:2377-85.

Reich, D., Patterson, N., Ramesh, V., De Jager, P.L., McDonald G.V., Tandon, A., Choy, E., et al. (2007) “Admixture mapping of an allele affecting serum IL6 and IL6 receptor levels.” American Journal of Human Genetics 80(4):716-26.

Choy, E. and Philips, M.R. (2001) “Green fluorescent protein-tagged Ras proteins for intracellular localization.” Methods in Enzymology 332, 50-64.

Choy, E. and Philips, M.R. (2000) “Expression and activity of a prenylcysteine-directed carboxyl methyltransferase.” Methods in Enzymology 325, 101-114.

Choy, E., Chiu, V.K., Silletti, J., Feoktistov, M., Morimoto, T., Michaelson, D., Ivanov, I.E., and Philips, M.R. (1999) “Endomembrane Trafficking of Ras: the CAAX Motif Targets Proteins to the ER and Golgi.” Cell 98, 69-80.

Dai, Q., Choy, E., Chiu, V., Romano, J., Slivka, S.R., Steitz, S.A., Michaelis, S., and Philips, M.R. (1998) “Mammalian Prenylcysteine Prenyltransferase is in the Endoplasmic Reticulum.” Journal of Biological Chemistry 273(24), 15030-15034.

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Dr. Choy specializes in the treatment of sarcoma and chordoma at the MGH Cancer Center and the Harris Center for Chordoma Care. Sarcomas are rare malignant tumors derived from connective tissue. Although a substantial group of sarcomas are characterized by a defined chromosomal translocations, the molecular basis for most subtypes of sarcomas is unknown.

In collaboration with other investigators at The Massachusetts General Hospital, The Dana-Farber Cancer Institute, and The Broad Institute, he utilizes high-throughput genotyping technology to understand the molecular basis of sarcomas in order to gain insight into novel therapeutic options for patients who would otherwise have no treatment alternatives.

In addition to this translational approach, his clinical research team collaborates closely with the sarcoma team at Dana-Farber in testing novel agents in a patient population in a phase I, II, or III setting. His team is currently enrolling patients onto clinical trials perturbing the IGF1R, mTor, src, DR5, VEGF, c-met, and hsp-90 pathways.

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