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Job Opportunities updated November
17, 2009 |
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Welcome to Boston!
Boston is a great place to live and work. From the
Boston Symphony Orchestra to the Museum of Fine Arts,
from Newbury Street galleries to the bookstores of Harvard
Square, this cosmopolitan city has enough cultural attractions
to keep you busy for a lifetime. 
Boston is America’s 20th largest city with a population of 650,000 and it has the nation's highest concentration of colleges with more than 250,000 students flocking to the city each fall. Boston is a city steeped in history where you can walk to Paul Revere's House, the Old North Church, the Boston Tea Party and Massacre sites, Faneuil Hall, the U.S.S. Constitution, the country’s first public library and ride the country’s first subway system to Fenway Park – home to the 2004 World Series Champions – the Boston Red Sox. Boston is also a city looking ahead to tomorrow. For centuries Boston has stood at the forefront of technological and civic transformation attracting scholars from across the world.
The Center for Human Genetic Research is located in the new Simches Research Center at the Massachusetts General Hospital. Situated in the center of the city and along the beautiful Charles River, the Massachusetts General Hospital is the third oldest hospital in the United States and the largest in New England. It consistently ranks as one of the country's best hospitals by U.S. News and World Report.
The CHGR offers an exceptional opportunity to learn and grow in an exciting and stimulating environment. If you'd like to join our team, have a look at our job opportunities below!
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| Postdoctoral Training Positions |
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Please contact individual
faculty directly to inquire about postdoctoral training
opportunities. While all faculty are always interested
in hearing from prospective applicants, below are some
specifically advertised positions.
Postdoctoral Fellow
The Center for Human Genetics Research at the Massachusetts
General Hospital is seeking a highly motivated post-doctoral
fellow to study Mucolipidosis type IV, a lysosomal storage
disorder caused by mutations in the gene encoding Mucolipin-1.
Our laboratory has recently created the mouse model
for MLIV therefore the project will involve handling
mouse models along with tissue culture and cell biology
research. Ultimately, we hope to discover effective
treatments aimed at abolishing the abnormal cellular
storage in this disease.
Suitable candidates should hold a Ph.D. in molecular
or cellular biology, neurobiology, or related discipline.
The successful candidate will have the ability to work
collaboratively and excellent oral and written communication
skills. Experience with mouse models, tissue culture
and cellular/molecular biology required.
To apply, please send you curriculum vitae and contact
information for three professional references to:
Susan A. Slaugenhaupt
Center for Human Genetic Research
Massachusetts General Hospital
Richard B. Simches Research Center
CPZN-5254
185 Cambridge Street
Boston, MA 02114
Phone: (617) 643-3091
slaugenhaupt@chgr.mgh.harvard.edu
Postdoctoral Fellow (Chemical Genomics)
Job Description: The Massachusetts General Hospital
Center for Human Genetic Research/Harvard Medical School
is seeking a highly motivated post-doctoral fellow in
the area of chemical genomics and stem cell models of
human disease. This is a unique opportunity for working
in a fast-paced, and highly collaborative research group
working at the interface of chemistry, biology, and
medicine. The emphasis of the position will be on the
use of reprogramming methods to generate genetically
accurate models of human diseases mechanisms and the
implementation of cell-based assays using high-content
imaging and automated microscopy. Candidates will be
required to use molecular and cell biology techniques,
including maintaining and manipulate mammalian fibroblast
and stem cell lines and using viral-mediated gene delivery.
The position will also require familiarity with the
use of genomic analysis methods, including gene expression
profiling and SNP detection.
Qualifications: PhD in cell biology, neurobiology,
or stem cell biology or related field. Must posses familiarity
with the operation of standard lab equipment, and techniques
related to mammalian cell culture, fluorescence microscopy,
immunocytochemistry, and molecular biology. Must have
excellent computer skills and ability to perform basic
quantitative analysis of large data sets. More advanced
statistics or programming skills a plus. Requires effective
oral and written communication skills along with meticulous
laboratory technique and recording skills. Must be able
to use discretion to organize workflow and to change
methodologies to optimize work results and communicate
effectively with all levels of staff to ensure that
work supports team goals.
Interested applicants should send curriculum vitae and
names of three references to:
Dr. Stephen Haggarty, Center for Human Genetic Research,
Massachusetts General Hospital, 185 Cambridge Street,
Boston, MA 02114, e-mail: haggarty@chgr.mgh.harvard.edu
Post-Doctoral Fellow
(Psychiatric Genetics, Pharmacogenetics, and Statistical
Genetics)
The Psychiatric and Neurodevelopmental Genetics Unit
in the MGH Center for Human Genetic Research and the
Psychiatric Genetics Program in Mood and Anxiety Disorders
in the MGH Department of Psychiatry has an immediate
opening for a postdoctoral position to conduct cutting-edge
genetic, statistical and bioinformatic analyses of large-scale
studies of a range of psychiatric phenotypes including
disease susceptibility and pharmacogenetic outcomes.
Ongoing studies include genomewide and candidate gene
analyses of antidepressant response, psychotic, mood,
and anxiety disorders, and substance use disorders.
Close supervision and intensive training will be provided
by a team of collegial experts in neuropsychiatric genetics,
statistical genetics, bioinformatics, and genetic epidemiology.
We seek a highly motivated and dedicated MD or PhD in
genetics, bioinformatics or statistical genetics with
excellent quantitative skills, proven ability to work
well in a collaborative environment, fluency with all
modes of communication in English, and strong writing
skills. The successful applicant will have strong training
in statistics or biostatistics, data mining, and genetic
analysis as well as experience with database management
and computer programming. To apply, please send a single
email containing your CV, a short statement describing
your qualifications for this position, and contact information
for three professional references to:
Dr. Jordan W. Smoller
e-mail: jsmoller@hms.harvard.edu
Postdoctoral Research Fellow
The Center for Human Genetics Research at the Massachusetts
General Hospital is seeking a highly motivated and versatile
post-doctoral fellow to study trinucleotide repeat instability
in Huntington’s disease. The lab employs a variety
of genetic, biochemical and cell-based approaches to
dissect mechanisms of repeat instability in accurate
genetic models of the disease. The position offers the
opportunity to work in a stimulating and highly collaborative
environment at the forefront of human genetic disease
research. Possible projects involve the generation of
novel mouse models to test specific hypotheses of repeat
instability, and the investigation of repeat instability
in induced pluripotent stem (iPS) cells derived from
HD patients.
Suitable candidates should hold a Ph.D. in genetics,
neurobiology, molecular/cellular biology or related
discipline. The successful candidate will have strong
background training in molecular biology and mammalian
cell culture, the ability to work collaboratively, and
excellent oral and written communication skills. Experience
with mouse embryonic stem (ES) cells including gene
targeting, manipulation of large pieces of genomic DNA
using BAC recombineering methodologies, mouse models,
and human iPS cells/stem cells is a plus.
To apply, please send you curriculum vitae and contact
information for three professional references to:
Dr. Vanessa Wheeler
email: wheeler@helix.mgh.harvard.edu
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| Staff Positions |
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Clinical Director of Phenotyping
The Autism Consortium funded study on Phenotype and
Genetic Factors in Autism Spectrum Disorders, operating
within the Psychiatric and Neurodevelopmental Genetics
Unit in the MGH Center for Human Genetic Research, has
an immediate opening for a Clinical Director of Autism
Phenotyping. This is a faculty level position, with
an academic appointment in the Department of Psychiatry
at Harvard Medical School.
The Autism Consortium (AC) is a scientific and clinical
collaboration involving 11 Boston area institutions.
Supported by a non-profit that is dedicated to facilitating
and funding research and clinical care, the Consortium’s
mission is to support a disease-based collaboration
dedicated to rapidly advancing the understanding, diagnosis,
and treatment of autism through collaborative research
to improve the care of children and families affected
by autism and related disorders. The mission of the
Phenotyping Core Project is to improve diagnostic and
assessment tools and improve understanding of the relationship
between individual phenotype and underlying genotype.
The applicant will work closely with the Principal
Investigator and the Clinical Research Program Manager
as part of the AC’s centralized Phenotyping Core,
will participate in all AC phenotyping activities, with
a focus on clinical research activities, including staff
training, research report writing, and family feedback.
Associated responsibilities will include daily research
flow/design, family screening, data collection, data
management, conference calls and meetings, manuscript
preparations, and proposal activity.
Principal Duties and Responsibilities:
• Provide training and ongoing supervision to
project staff in the administration and scoring of all
standardized measures required for the core phenotype
research battery, including cognitive, language and
related assessments.
• Provide training in the administration and scoring
of ADI-R and ADOS and ensure maintenance of research
reliability.
• Compose research reports for study participants,
summarizing the findings of the project assessment battery
for affected individuals.
• Provide verbal feedback to families and provide
clinical referrals as needed.
• Organize and lead AC ‘Journal Club’,
summarizing recent empirical literature and coordinating
presentations from AC members.
• Carry out data extraction, analyses and reporting
for presentations of phenotype data at relevant academic
conferences.
Qualifications: PhD level psychologist
with training in related field(s) (neuropsychology,
clinical psychology, developmental psychology, etc.)
required. Excellent organizational, interpersonal and
communication skills required. Previous supervisory
experience required.
Skills/Abilities/Competencies Required:
Ability to work well with a team and function as a leader
and team member; to make independent effective decisions,
knowledge of research design; strong organizational,
oral and written communications skills; strong database
management and clear understanding of clinical and research
data bases. At least 5 years experience with administration
of ADI-R and ADOS required, as well as at least 3 years
experience training others on these instruments.
Interested applicants should send curriculum vitae and
names of three references to:
Dr. Susan Santangelo
Center for Human Genetic Research
Massachusetts General Hospital
CPZN-6256
185 Cambridge Street
Boston, MA 02114
email:
ssantangelo@pngu.mgh.harvard.edu
Senior Research Scientist (Biochemistry)
Job Description: The Massachusetts
General Hospital Center for Human Genetic Research/Harvard
Medical School is seeking a highly motivated individual
to developing chemical screens for targets relevant
to neuropsychiatric and neurodegenerative disorders.
Emphasis will be on the development of novel enzymatic
assays and cell-based secondary assays and the integration
of this information with structural biology. Projects
will involve detailed knowledge of enzymology and protein
biochemistry. Position is ideal for those interested
in CNS pharmacology and drug discovery.
Qualifications: a PhD in biochemistry,
molecular biology, cell biology, or related field required
with at least 2 years of laboratory experiences in an
laboratory environment preferably working on an independent
project. Must also have an in-depth understanding of
the principles of enzymology and knowledge of high-throughput
screening approaches. Familiarity with biophysical approaches
to characterizing protein-small molecule interactions
and structural biology a plus. Must have familiarity
with the operation of standard lab equipment, and techniques
related to mammalian cell culture, fluorescence microscopy,
immunocytochemistry, and molecular biology (cloning,
RT-PCR, western blotting). Must have excellent computer
skills and ability to perform basic quantitative analysis
of large data sets. Knowledge of programs such as Spotfire,
PipelinePilot and GraphPrism would be preferred. More
advanced statistics or programming skills a plus. Excellent
critical thinking skills and attention to detail needed.
Must be able to use sound judgment to effectively solve
problems, work independently, and handle a variety of
tasks. Requires effective oral and written communication
skills along with meticulous laboratory technique and
recording skills. Must be able to use discretion to
organize workflow and to change methodologies to optimize
work results and communicate effectively with all levels
of staff to ensure that work supports team goals.
Interested applicants should send curriculum vitae
and names of three references to:
Dr. Stephen Haggarty, Center for Human Genetic Research,
Massachusetts General Hospital, 185 Cambridge Street,
Boston, MA 02114,
email: haggarty@chgr.mgh.harvard.edu
Senior Research Scientist (Neural Stem Cell
Biology)
Job Description: The Massachusetts
General Hospital Center for Human Genetic Research/Harvard
Medical School is seeking a highly motivated individual
to fill a Research Scientist position in the area of
neural stem cell biology and neurodevelopment. The focus
will be on the use of molecular techniques to characterize
the effects of small-molecule probes on disease genes
and pathways. In addition, the project will involve
the integration of these data with results from other
model organisms, including mouse and zebrafish. This
is a unique opportunity for working in a fast-paced,
and highly collaborative, translational research group
working at the interface of chemistry, biology, and
therapeutic development.
Qualifications: PhD in neurobiology,
molecular biology, or related field required. Must have
1-2 years experience in working with stem cells and
have demonstrated expertise in the use of fluorescence
microscopy, flow cytometry, cellular imaging/microscopy,
and molecular biology (RT-PCR, western blotting). Additional
expertise in the use of siRNA and recombinant viral
vector systems would be an advantage. Prior work with
small molecules and familiarity with high-throughput
screening a plus. Must posses excellent computer skills
and ability to perform basic quantitative analysis of
large data sets. Knowledge of programs such as Spotfire,
PipelinePilot and GraphPrism would be preferred. More
advanced statistics or programming skills a plus. Excellent
critical thinking skills and attention to detail needed.
Must be able to use sound judgment to effectively solve
problems, work independently, and handle a variety of
tasks. Requires effective oral and written communication
skills along with meticulous laboratory technique and
recording skills. Must be able to use discretion to
organize workflow and to change methodologies to optimize
work results and communicate effectively with all levels
of staff to ensure that work supports team goals.
Interested applicants should send curriculum vitae and
names of three references to:
Dr. Stephen Haggarty, Center for Human Genetic Research,
Massachusetts General Hospital, 185 Cambridge Street,
Boston, MA 02114,
email:
haggarty@chgr.mgh.harvard.edu
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| Technician Positions |
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Research Technician II
Job Description: The Massachusetts
General Hospital Center for Human Genetic Research/Harvard
Medical School is seeking a highly motivated individual
to fill a Research Technician II position to study the
molecular genetics of neurodegenerative diseases. The
work involves the use of classic molecular biology techniques
(cloning, DNA and RNA extraction, PCR, RT-PCR, gel analysis,
western blotting), cell biology (cell culture) and broad-scale
genomics approaches (gene expression microarrays, proteomics).
Responsibilities will include performing molecular biology
laboratory research and providing technical support
for members of the lab.
Qualifications: The applicant should
have an interest in cellular and molecular biology with
at least 2 years of laboratory experience including
standard techniques, western blotting and tissue culture.
The ideal candidate will possess excellent critical
thinking and organizational skills, pays close attention
to detail, is willing to learn, is comfortable carrying
out their work independently and enjoys working in a
team environment. Minimum degree and field of knowledge:
BS/BA. 2 year commitment preferred.
Interested candidates should submit their curriculum
vitae and contact information to:
Karen L. Durant-Faria
kdurantfaria@partners.org
Phone: (617) 643-3388
Senior Research Technologist (Chemical Genomics)
Job Description: The Massachusetts
General Hospital Center for Human Genetic Research/Harvard
Medical School is seeking a highly motivated individual
to fill a Senior Research Technologist position in the
area of high-throughput screening/assay development
with a focus on brain disorders. Overall the position
will support the development and implementation of cell-
and protein-based assays for chemical lead discovery.
This is a unique opportunity for working in a fast-paced,
and highly collaborative, translational research group
working at the interface of chemistry, biology, and
therapeutic development. The position will involve responsibility
for operation of robotic liquid-handling systems, plate
readers, and high-content imaging systems, as well as
training group members in the use of instruments as
needed. The position will also require formatting and
managing a compound library to support probe development
efforts.
Qualifications: PhD in molecular biology,
chemistry, or related field required with at least 2
years of laboratory experiences in an environment involving
work with robotics, HTS, small molecule or RNAi libraries.
Must posses familiarity with the operation of standard
lab equipment, and techniques related to mammalian cell
culture, fluorescence microscopy, and molecular biology.
Must posses excellent computer skills and ability to
perform basic quantitative analysis of large data sets.
Knowledge of programs such as Spotfire, PipelinePilot
and GraphPrism would be preferred. More advanced statistics
or programming skills a plus. Excellent critical thinking
skills and attention to detail needed. Must be able
to use sound judgment to effectively solve problems,
work independently, and handle a variety of tasks. Requires
effective oral and written communication skills along
with meticulous laboratory technique and recording skills.
Must be able to use discretion to organize workflow
and to change methodologies to optimize work results
and communicate effectively with all levels of staff
to ensure that work supports team goals.
Interested applicants should send curriculum vitae and
names of three references to:
Dr. Stephen Haggarty, Center for Human Genetic Research,
Massachusetts General Hospital, 185 Cambridge Street,
Boston, MA 02114,
email: haggarty@chgr.mgh.harvard.edu
NOTICE OF FILING
This notice is provided as a result
of the filing of an application for permanent labor
certification. Any person may provide documentary evidence
bearing on the application to the Certifying Officer
of the Department of Labor, Employment and Training,
Foreign Labor Certification, National Processing Center,
Harris Tower, 233 Peachtree St., Suite 410, Atlanta,
GA 30303.
Massachusetts General Hospital is filing
an Application for Alien Employment Certification for
the following position located in Boston, MA:
Assistant in Research to independently
lead autism research studies focusing on genes involved
in a particular form of brain synaptic plasticity and
neuronal pathways related to brain and synaptic development
and functions; independently lead autism research on
epidemiological factors associated with autism. Serve
as a consultant to collaborate with a group that is
designing a new autism data software (Query Data) by
reviewing data and advise them for changing useless,
inaccurate or ambiguous variables, as well as teaching
autism diagnostic tools and IQ assessment tests to their
software designers enabling them to have a better insight
into autism and to design more accurate software. Prepare
research team to ascertain future samples for genetic
study focused on a given population by teaching ADI
and ADOS techniques; review the lab researchers' taped
interviews; check and discuss their coding scores; provide
guidance regarding reliability; and teach researchers
ethical issues surrounding data capture and blood sample
collection. Prepare and supervise team regarding the
SPSS and SAS statistical analyses for epidemiological
studies of environmental risk factors for autism. Teach
and supervise lab researchers regarding specialized
tasks such as estimating gene location from UCSC and
Aceview, and Tag SNPs selection using software such
as HapMap, dbSNP, SNPper and tagger. Prepare research
progress reports for ongoing proposals as well as prepare
manuscripts for publication. Write grant requests to
fund research on the genetic and environmental risk
factors for autism. Choose appropriate tag SNPs based
on quality control measures and population, prepare
samples for genotyping, and order primers for selected
tagSNPs. Prepare samples for genotyping, perform DNA
extraction, prepare Pico Greening samples (quantification
of DNA), carry out purification for low concentrated
samples, prepare dilution plate based on type of platform,
and carry out genotyping. Collaborate with colleagues
in Autism Spectrum Disorder diagnosis; participate in
family visits for ADI and ADOS diagnostic instruments;
and prepare research team to ascertain future sample
for genetic study focused on a given population. Independently
write grant applications to acquire research funding
for studies on the genetic and environmental risk factors
for autism. 40/hr/wk. Salary $75,000/year. Must have
MD or Ph. D. in Developmental Psychiatry, Clinical Psychiatry,
Genetic Epidemiology, or Statistical Genetic. Must also
have five years of experience in the same type of position
or five years of experience in any post-doctoral or
post-M.D. scientific or medical occupation involving
research on autism and diagnosis of autism, including
experience with statistical genetics, human molecular
genetics, and genotyping and genetic data analysis using
plink and FBAT. Contact Dr. Susan L.Santangelo, Psychiatric
& Neurodevelopmental Genetics Unit, Center for Human
Genetic Research, Massachusetts General Hospital,185
Cambridge Street, CPZN 6-256, Boston, MA 02114.
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