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Job Opportunities updated November
29, 2011 |
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Welcome to Boston!
Boston is a great place to live and work. From the
Boston Symphony Orchestra to the Museum of Fine Arts,
from Newbury Street galleries to the bookstores of Harvard
Square, this cosmopolitan city has enough cultural attractions
to keep you busy for a lifetime. 
Boston is America’s 20th largest city with a population of 650,000 and it has the nation's highest concentration of colleges with more than 250,000 students flocking to the city each fall. Boston is a city steeped in history where you can walk to Paul Revere's House, the Old North Church, the Boston Tea Party and Massacre sites, Faneuil Hall, the U.S.S. Constitution, the country’s first public library and ride the country’s first subway system to Fenway Park – home to the 2004 World Series Champions – the Boston Red Sox. Boston is also a city looking ahead to tomorrow. For centuries Boston has stood at the forefront of technological and civic transformation attracting scholars from across the world.
 The Center for Human Genetic Research is located in the new Simches Research Center at the Massachusetts General Hospital. Situated in the center of the city and along the beautiful Charles River, the Massachusetts General Hospital is the third oldest hospital in the United States and the largest in New England. It consistently ranks as one of the country's best hospitals by U.S. News and World Report.
The CHGR offers an exceptional opportunity to learn and grow in an exciting and stimulating environment. If you'd like to join our team, have a look at our job opportunities below!
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| Postdoctoral Training Positions |
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Please contact individual
faculty directly to inquire about postdoctoral training
opportunities. While all faculty are always interested
in hearing from prospective applicants, below are some
specifically advertised positions.
Postdoctoral Fellowship in iPSC-based studies
of the Neurobiology of Schizophrenia and Bipolar Disorder
A postdoctoral fellow position is available in the
MGH Center for Human Genetic Research to study induced
pluripotent stem cell (iPSC)-derived neuronal cells
from patients with schizophrenia and bipolar disorder
to identify disease signatures by using chemical biology
and functional genomics approaches. The overall goal
is to discover cellular signatures for schizophrenia
and bipolar disorder in iPSC-derived neurons using phenotypic
and gene expression studies.
Signature-based high-throughput screens will then be
used to identify novel small molecule probes to investigate
the disease biology of schizophrenia and bipolar disorder
and to provide leads for therapeutic development. The
project entails close collaboration with the Chemical
Biology Program at the Broad Institute of Harvard and
MIT. The fellow will have simultaneous academic appointments
at the Massachusetts General Hospital and Harvard Medical
School.
Qualifications: PhD in neurobiology,
molecular biology, or related field required. Must have
1-2 years experience in working with stem cells and
have demonstrated expertise in the use of fluorescence
microscopy, flow cytometry, cellular imaging/microscopy,
and molecular biology (RT-PCR, cloning, immunoprecipitation,
western blotting). Additional expertise in the use of
RNA interference and viral vectors preferred.
Candidates should include an updated CV, complete contact
information for three references, and a cover letter
describing their past research experience, career goals
and potential future research interests.
Applicants should send materials to:
Rakesh Karmacharya, MD, PhD
email: karmacharya@mcb.harvard.edu
Statistical Geneticist Post-Doctoral Positions
Available
Collaborative research efforts co-led by Drs. Jose
Florez and David
Altshuler are seeking post-doctoral candidates with
experience in statistical genetics and/or computational
biology, for high-throughput genetic projects in admixed
populations around type 2 diabetes and related traits.
Available funded projects involve the conduct and analysis
of third-generation/high-density (1000 Genomes-based)
genome-wide association scans in Latinos; implementation
and development of imputation and admixture tools; next-generation
sequencing projects in individuals with familial or
extreme phenotypes; analysis of high-throughput, phenotype-specific
genotype data in an NIH-funded multi-ethnic clinical
trial of diabetes prevention; and design and analysis
of genotype-based physiological analyses in ongoing
pharmacogenetic studies.
The relevant research groups operate synergistically
at both the Program in Medical Genetics at the Broad
Institute (www.broadinstitute.org)
and the Center for Human
Genetic Research at the Massachusetts
General Hospital (http://www2.massgeneral.org/chgr/),
in close collaboration with colleagues at the newly
constituted Analytic and Translational Genetics Unit
(directed by Mark Daly).
Scientists interact in a stimulating intellectual environment
enriched by population geneticists, clinicians, statisticians,
computational biologists, physiologists, and epidemiologists.
A variety of large and well-phenotyped datasets are
available for the development and testing of innovative
research tools, as well as for medically relevant scientific
discovery.
The candidate should have received a doctoral degree
in epidemiology, statistics, computational biology or
related disciplines. He/she should be familiar with
modern statistical methods in the analysis of genetic
data, and have experience with mining and curating large-scale
datasets. A strong background in statistical concepts
is essential. Applicants should enjoy working in a multi-disciplinary
environment, excel in their interpersonal skills, and
pay attention to detail. Demonstrated ability to meet
project deadlines, prioritize tasks, manage complex
projects, and communicate in spoken and written English
effectively is highly desirable.
The target starting date is spring 2011 (a doctorate
graduation date of June 2011 is acceptable). Competitive
salary and benefits commensurate to the cost of living
in the Boston area will be provided. Women/minorities
are encouraged to apply.
If interested, please email a cover letter and attach
your resume and the names/contact information for three
professional references to:
Dr. Jose Florez at jcflorez@partners.org.
Postdoctoral Position in the Saxena Lab
Genetics of circadian pathways in type 2 diabetes
The Saxena laboratory at Massachusetts General Hospital
(Center for Human Genetics Research and Department of
Anesthesia, Critical Care and Pain Medicine) is seeking
a talented Postdoctoral fellow to study the molecular
and physiologic function of circadian and sleep genes
in metabolism, based on the recent discovery of circadian
type 2 diabetes genes using genome-wide association
studies (GWAS).
Specifically, the candidate will identify causal variants
and genes from GWAS and exome sequencing, assess function
using molecular genetics and cell culture models, develop
iPS cell models of causal variants, and understand the
mechanism by which causal risk variants alter sleep,
circadian and metabolic physiology.
The fellow will have the opportunity to participate
in study design, acquire experimental data, analyze
large scale data, and present research results regularly
at lab and local scientific meetings. Candidates with
Ph.D., M.D. or both degrees and relevant experience
in human genetics, genomics, molecular biology techniques,
and/or experience with cell culture are encouraged to
apply. Skills in bioinformatics are highly valued. A
track record of excellence should be evident in past
publications and scholarly activities. Excellent problem
solving, oral and written communication skills are a
must. The research is highly collaborative and the applicant
must possess the ability to interact with multidisciplinary
staff in a fast-paced environment. A competitive stipend
and excellent benefits will be provided for this position.
Interested candidates should email their CV, cover letter
and 3 references to: rsaxena@chgr.mgh.harvard.edu
Post-Doctoral Research Fellow Position: Computational
Models of Neuropsychiatric Disease Risk
Job Description:
We are looking to recruit a highly motivated postdoctoral
research fellow to join a multidisciplinary translational
research group focusing on developing innovative applications
of machine learning to stratify risk for disease and
treatment outcomes of neuropsychiatric disorders. The
Laboratory of Psychiatric Pharmacogenomics (R. Perlis,
PI) and Dr. Purcell's Laboratory are part of the Center
for Human Genetics, one of 5 thematic centers at the
Massachusetts General Hospital/Harvard Medical School
and are also closely integrated with the Stanley Center
for Psychiatric Research at the Broad Institute. The
focus will be on the development and implementation
of computational models of risk which integrate clinical
and genomic data. Projects might include computational
aspects of large-scale whole genome association studies,
analysis of sequence and structural variation data,
analysis of whole exome sequence data, computational
and statistical methods development, pharmacogenomic
studies, integration of genetic variation and gene expression
data, pathway analysis and related areas. In addition,
the project will involve the integration of results
with ongoing clinical studies aiming to characterize
outcomes in mood and psychotic disorders. This is a
unique opportunity for working in a fast-paced, and
highly collaborative, translational research group working
at the interface of clinical investigation, biology,
and therapeutic development.
Qualifications:
- Ph.D., MD/Ph.D., or MD in Genetic Epidemiology,
Biostatistics, and/or Computational Biology required,
which may include advanced degrees in math or physics.
- Expert level statistical and programming skills
(Unix and database skills)
- Demonstrated success in technical proficiency,
scientific creativity, collaboration with others and
independent thought.
- Ideally, familiarity with statistical genetics
packages and experience working on large-scale genetics
and genomics projects
- Proven record of significant contributions to research
projects as individual contributor.
- Excellent communication skills
Interested applicants should send cover letter, curriculum
vitae, and the names, telephone numbers, and email addresses
of three references to:
rperlis@chgr.mgh.harvard.edu
Roy Perlis, MD MSc
Simches Research Building
185 Cambridge St., 6th Floor
Boston, MA 02114
http://pngu.mgh.harvard.edu/~perlis/
http://pngu.mgh.harvard.edu/~purcell/
Postdoctoral position in the Soukas lab
Genomics and genetics of fat storage in mice and mammalian
cells
Postdoctoral fellow position available in the Soukas
lab in Massachusetts General Hospital/Harvard Medical
School, Boston, MA. This lab, located in the ultramodern
Simches Research Building within the Center for Human
Genetic Research (http://www.massgeneral.org/chgr),
studies the complex genetics of obesity and diabetes
using vertebrate and invertebrate genetics, physiology,
and metabolism.
Postdoctoral fellows will use and develop models of
mammalian obesity and diabetes based upon genetic and
genomic data from C. elegans fat screens. Mice have
been constructed and are ready for molecular and physiologic
studies immediately. Interested individuals should have
experience in mouse metabolism, including body mass
and composition measurements, insulin and glucose homeostasis,
ELISA measurements of hormone levels, molecular biology
(cloning, real-time PCR, genotyping) and biochemistry
(western blotting and immunoprecipitation). The lab
employs a multidisciplinary approach using genomics,
genetics, molecular biology, biochemistry, and microscopy.
We are seeking a highly motivated individual with a
doctorate degree in molecular biology, biochemistry,
genetics, or related sciences. Prior lab experience
in genetics, genomics, biochemistry, or metabolism is
essential. Experience with mice and/or cell culture
metabolism is also critical. The fellow will conduct
independent scientific experiments designed in conjunction
with Dr. Soukas and will present at lab meetings and
at local scientific conferences. It is important that
the candidate possess an eagerness to learn new scientific
ideas and methods.
Interested applicants should submit their CV and references
to soukaslab@gmail.com.
Postdoctoral position in the Soukas lab
C. elegans genomics and genetics of fat storage
Postdoctoral fellow position available in the Soukas
lab in Massachusetts General Hospital/Harvard Medical
School, Boston, MA. This lab, located in the ultramodern
Simches Research Building within the Center for Human
Genetic Research (http://www.massgeneral.org/chgr),
studies the complex genetics of obesity and diabetes
using vertebrate and invertebrate genetics, physiology,
and metabolism.
Postdoctoral fellows will conduct systems level genetic
and genomic experiments using C. elegans to identify
and analyze genes required for normal fat storage. The
lab employs a multidisciplinary approach using genomics,
genetics, molecular biology, biochemistry, and microscopy.
We are seeking a highly motivated individual with a
doctorate degree in molecular biology, biochemistry,
genetics, or related sciences. Prior lab experience
in genetics, genomics, biochemistry, or metabolism is
preferred. Experience with C. elegans is not necessary,
but of value. Skills in bioinformatics are highly valued.
The fellow will conduct independent scientific experiments
designed in conjunction with Dr. Soukas and will present
at lab meetings and at local scientific conferences.
It is important that the candidate possess an eagerness
to learn new scientific ideas and methods.
Interested applicants should submit their CV and references
to soukaslab@gmail.com.
Postdoctoral Fellow (Chemical Genomics)
Job Description: The Massachusetts General Hospital
Center for Human Genetic Research/Harvard Medical School
is seeking a highly motivated post-doctoral fellow in
the area of chemical genomics and stem cell models of
human disease. This is a unique opportunity for working
in a fast-paced, and highly collaborative research group
working at the interface of chemistry, biology, and
medicine. The emphasis of the position will be on the
use of reprogramming methods to generate genetically
accurate models of human diseases mechanisms and the
implementation of cell-based assays using high-content
imaging and automated microscopy. Candidates will be
required to use molecular and cell biology techniques,
including maintaining and manipulate mammalian fibroblast
and stem cell lines and using viral-mediated gene delivery.
The position will also require familiarity with the
use of genomic analysis methods, including gene expression
profiling and SNP detection.
Qualifications: PhD in cell biology, neurobiology,
or stem cell biology or related field. Must posses familiarity
with the operation of standard lab equipment, and techniques
related to mammalian cell culture, fluorescence microscopy,
immunocytochemistry, and molecular biology. Must have
excellent computer skills and ability to perform basic
quantitative analysis of large data sets. More advanced
statistics or programming skills a plus. Requires effective
oral and written communication skills along with meticulous
laboratory technique and recording skills. Must be able
to use discretion to organize workflow and to change
methodologies to optimize work results and communicate
effectively with all levels of staff to ensure that
work supports team goals.
Interested applicants should send curriculum vitae and
names of three references to:
Dr. Stephen Haggarty, Center for Human Genetic Research,
Massachusetts General Hospital, 185 Cambridge Street,
Boston, MA 02114, e-mail: haggarty@chgr.mgh.harvard.edu
Post-Doctoral Fellow
(Psychiatric Genetics, Pharmacogenetics, and Statistical
Genetics)
The Psychiatric and Neurodevelopmental Genetics Unit
in the MGH Center for Human Genetic Research and the
Psychiatric Genetics Program in Mood and Anxiety Disorders
in the MGH Department of Psychiatry has an immediate
opening for a postdoctoral position to conduct cutting-edge
genetic, statistical and bioinformatic analyses of large-scale
studies of a range of psychiatric phenotypes including
disease susceptibility and pharmacogenetic outcomes.
Ongoing studies include genomewide and candidate gene
analyses of antidepressant response, psychotic, mood,
and anxiety disorders, and substance use disorders.
Close supervision and intensive training will be provided
by a team of collegial experts in neuropsychiatric genetics,
statistical genetics, bioinformatics, and genetic epidemiology.
We seek a highly motivated and dedicated MD or PhD in
genetics, bioinformatics or statistical genetics with
excellent quantitative skills, proven ability to work
well in a collaborative environment, fluency with all
modes of communication in English, and strong writing
skills. The successful applicant will have strong training
in statistics or biostatistics, data mining, and genetic
analysis as well as experience with database management
and computer programming. To apply, please send a single
email containing your CV, a short statement describing
your qualifications for this position, and contact information
for three professional references to:
Dr. Jordan W. Smoller
e-mail: jsmoller@hms.harvard.edu |
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| Staff Positions |
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Clinical Director of Phenotyping
The Autism Consortium funded study on Phenotype and
Genetic Factors in Autism Spectrum Disorders, operating
within the Psychiatric and Neurodevelopmental Genetics
Unit in the MGH Center for Human Genetic Research, has
an immediate opening for a Clinical Director of Autism
Phenotyping. This is a faculty level position, with
an academic appointment in the Department of Psychiatry
at Harvard Medical School.
The Autism Consortium (AC) is a scientific and clinical
collaboration involving 11 Boston area institutions.
Supported by a non-profit that is dedicated to facilitating
and funding research and clinical care, the Consortium’s
mission is to support a disease-based collaboration
dedicated to rapidly advancing the understanding, diagnosis,
and treatment of autism through collaborative research
to improve the care of children and families affected
by autism and related disorders. The mission of the
Phenotyping Core Project is to improve diagnostic and
assessment tools and improve understanding of the relationship
between individual phenotype and underlying genotype.
The applicant will work closely with the Principal
Investigator and the Clinical Research Program Manager
as part of the AC’s centralized Phenotyping Core,
will participate in all AC phenotyping activities, with
a focus on clinical research activities, including staff
training, research report writing, and family feedback.
Associated responsibilities will include daily research
flow/design, family screening, data collection, data
management, conference calls and meetings, manuscript
preparations, and proposal activity.
Principal Duties and Responsibilities:
• Provide training and ongoing supervision to
project staff in the administration and scoring of all
standardized measures required for the core phenotype
research battery, including cognitive, language and
related assessments.
• Provide training in the administration and scoring
of ADI-R and ADOS and ensure maintenance of research
reliability.
• Compose research reports for study participants,
summarizing the findings of the project assessment battery
for affected individuals.
• Provide verbal feedback to families and provide
clinical referrals as needed.
• Organize and lead AC ‘Journal Club’,
summarizing recent empirical literature and coordinating
presentations from AC members.
• Carry out data extraction, analyses and reporting
for presentations of phenotype data at relevant academic
conferences.
Qualifications: PhD level psychologist
with training in related field(s) (neuropsychology,
clinical psychology, developmental psychology, etc.)
required. Excellent organizational, interpersonal and
communication skills required. Previous supervisory
experience required.
Skills/Abilities/Competencies Required:
Ability to work well with a team and function as a leader
and team member; to make independent effective decisions,
knowledge of research design; strong organizational,
oral and written communications skills; strong database
management and clear understanding of clinical and research
data bases. At least 5 years experience with administration
of ADI-R and ADOS required, as well as at least 3 years
experience training others on these instruments.
Interested applicants should send curriculum vitae and
names of three references to:
Dr. Susan Santangelo
Center for Human Genetic Research
Massachusetts General Hospital
CPZN-6256
185 Cambridge Street
Boston, MA 02114
email:
ssantangelo@pngu.mgh.harvard.edu
Senior Research Scientist (Biochemistry)
Job Description: The Massachusetts
General Hospital Center for Human Genetic Research/Harvard
Medical School is seeking a highly motivated individual
to developing chemical screens for targets relevant
to neuropsychiatric and neurodegenerative disorders.
Emphasis will be on the development of novel enzymatic
assays and cell-based secondary assays and the integration
of this information with structural biology. Projects
will involve detailed knowledge of enzymology and protein
biochemistry. Position is ideal for those interested
in CNS pharmacology and drug discovery.
Qualifications: a PhD in biochemistry,
molecular biology, cell biology, or related field required
with at least 2 years of laboratory experiences in an
laboratory environment preferably working on an independent
project. Must also have an in-depth understanding of
the principles of enzymology and knowledge of high-throughput
screening approaches. Familiarity with biophysical approaches
to characterizing protein-small molecule interactions
and structural biology a plus. Must have familiarity
with the operation of standard lab equipment, and techniques
related to mammalian cell culture, fluorescence microscopy,
immunocytochemistry, and molecular biology (cloning,
RT-PCR, western blotting). Must have excellent computer
skills and ability to perform basic quantitative analysis
of large data sets. Knowledge of programs such as Spotfire,
PipelinePilot and GraphPrism would be preferred. More
advanced statistics or programming skills a plus. Excellent
critical thinking skills and attention to detail needed.
Must be able to use sound judgment to effectively solve
problems, work independently, and handle a variety of
tasks. Requires effective oral and written communication
skills along with meticulous laboratory technique and
recording skills. Must be able to use discretion to
organize workflow and to change methodologies to optimize
work results and communicate effectively with all levels
of staff to ensure that work supports team goals.
Interested applicants should send curriculum vitae
and names of three references to:
Dr. Stephen Haggarty, Center for Human Genetic Research,
Massachusetts General Hospital, 185 Cambridge Street,
Boston, MA 02114,
email: haggarty@chgr.mgh.harvard.edu
Senior Research Scientist (Neural Stem Cell
Biology)
Job Description: The Massachusetts
General Hospital Center for Human Genetic Research/Harvard
Medical School is seeking a highly motivated individual
to fill a Research Scientist position in the area of
neural stem cell biology and neurodevelopment. The focus
will be on the use of molecular techniques to characterize
the effects of small-molecule probes on disease genes
and pathways. In addition, the project will involve
the integration of these data with results from other
model organisms, including mouse and zebrafish. This
is a unique opportunity for working in a fast-paced,
and highly collaborative, translational research group
working at the interface of chemistry, biology, and
therapeutic development.
Qualifications: PhD in neurobiology,
molecular biology, or related field required. Must have
1-2 years experience in working with stem cells and
have demonstrated expertise in the use of fluorescence
microscopy, flow cytometry, cellular imaging/microscopy,
and molecular biology (RT-PCR, western blotting). Additional
expertise in the use of siRNA and recombinant viral
vector systems would be an advantage. Prior work with
small molecules and familiarity with high-throughput
screening a plus. Must posses excellent computer skills
and ability to perform basic quantitative analysis of
large data sets. Knowledge of programs such as Spotfire,
PipelinePilot and GraphPrism would be preferred. More
advanced statistics or programming skills a plus. Excellent
critical thinking skills and attention to detail needed.
Must be able to use sound judgment to effectively solve
problems, work independently, and handle a variety of
tasks. Requires effective oral and written communication
skills along with meticulous laboratory technique and
recording skills. Must be able to use discretion to
organize workflow and to change methodologies to optimize
work results and communicate effectively with all levels
of staff to ensure that work supports team goals.
Interested applicants should send curriculum vitae and
names of three references to:
Dr. Stephen Haggarty, Center for Human Genetic Research,
Massachusetts General Hospital, 185 Cambridge Street,
Boston, MA 02114,
email:
haggarty@chgr.mgh.harvard.edu
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| Technician Positions |
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Research Tecnician position in the Haggarty lab
Job Description: The Haggarty Laboratory
within the Massachusetts General Hospital Center for
Human Genetic Research/Harvard Medical School is seeking
a highly motivated individual to work in the area of
chemical neurobiology and translational neuroscience.
Position is ideal for those interested in neural stem
cell biology, neurobiology, and CNS pharmacology. This
is a two-year appointment with the possibility of renewal
based on merit and achievement.
Principal duties and responsibilities will include
performing cutting edge research in the following areas:
molecular/cellular biology, neural stem cells, protein
biochemistry, imaging, synapse biology and neurochemistry.
Candidates should have a proven track record in contributing
to scientific research at an advanced level in an academic
or industrial setting. Excellent critical thinking skills
and attention to detail needed. Must be able to use
sound judgment to effectively solve problems, work independently,
and handle a variety of tasks. Requires excellent oral
and written communication skills along with meticulous
laboratory technique and recording skills.
Must have clear experience in aseptic techniques including,
but not limited to the culture of mammalian cell lines,
primary tissue culture and long-term cultures. Experience
with neural cell culture and/or stem cells highly desired.
Additionally, bench-level experience in biochemical
assays such as Western analysis, PCR and RT-PCR, immunohistochemistry,
ELISA, luminescence, etc. is required.
General understanding of the principles of high-throughput
screening approaches including familiarity with the
use of automated methods such as liquid handling, microscopy
and multiwell or multiplexed biochemical analysis is
highly desirable. Must have excellent computer skills,
the ability to perform quantitative analysis and be
able to execute the handling of large data sets. Knowledge
of programs such as Spotfire, PipelinePilot and GraphPad
Prism would be preferred. More advanced statistics or
programming skills a plus. Must be able to use discretion
to organize workflow and to change methodologies to
optimize work results and communicate effectively with
all levels of staff to ensure that work supports team
goals. May be required to train and assist other members
of the research team and collaborating labs.
Qualifications: Masters degrees in
cell biology, neurobiology, biochemistry, molecular
biology or related field required with at least an additional
4-6 years of laboratory experience. Experience in tissue
culture techniques required. Stem cell related research
experience greatly preferred but not required. Recent
Ph.D. graduates in the above fields are encouraged to
apply.
Interested applicants should send curriculum vitae
and names of three references to:
Dr. Stephen Haggarty, Center for Human Genetic Research,
Massachusetts General Hospital, 185 Cambridge Street,
Boston, MA 02114,
email: haggarty@chgr.mgh.harvard.edu
Research Tecnician position in the Soukas lab
A Research Assistant/Technician position is available
in the Soukas lab in Massachusetts General Hospital/Harvard
Medical School, Boston, MA. This lab, located in the
ultramodern Simches Research Building within the Center
for Human Genetic Research (http://www.massgeneral.org/chgr),
studies the complex genetics of obesity and diabetes
using vertebrate and invertebrate genetics, physiology,
and metabolism.
We use C. elegans to conduct high-througput genomic
and genetic analysis of genes required for normal fat
storage. Mouse models of metabolism are subsequently
developed to study metabolism in a mammalian setting.
The lab employs a multidisciplinary approach using genomics,
genetics, molecular biology, biochemistry, and microscopy.
We are seeking a highly motivated individual with at
least a Bachelor's degree in molecular biology, biochemistry,
genetics, biological or related sciences. Prior lab
experience is required. Experience with C. elegans is
preferred, but not essential. Experience with mice and
cell culture is also of tremendous value. The lab technician
will be a full member of the lab, participating in research
and in lab management and organizational tasks. The
job will include independent scientific and organizational
duties such as conducting an independent research project,
keeping meticulous records, and presenting at lab meetings
and at local scientific conferences. It is important
that the candidate possess an eagerness to learn new
scientific ideas and methods.
A two- or three-year commitment is preferred. Interested
applicants should submit CV and references to soukaslab@gmail.com.
Senior Research Technologist (Chemical Genomics)
Job Description: The Massachusetts
General Hospital Center for Human Genetic Research/Harvard
Medical School is seeking a highly motivated individual
to fill a Senior Research Technologist position in the
area of high-throughput screening/assay development
with a focus on brain disorders. Overall the position
will support the development and implementation of cell-
and protein-based assays for chemical lead discovery.
This is a unique opportunity for working in a fast-paced,
and highly collaborative, translational research group
working at the interface of chemistry, biology, and
therapeutic development. The position will involve responsibility
for operation of robotic liquid-handling systems, plate
readers, and high-content imaging systems, as well as
training group members in the use of instruments as
needed. The position will also require formatting and
managing a compound library to support probe development
efforts.
Qualifications: PhD in molecular biology,
chemistry, or related field required with at least 2
years of laboratory experiences in an environment involving
work with robotics, HTS, small molecule or RNAi libraries.
Must posses familiarity with the operation of standard
lab equipment, and techniques related to mammalian cell
culture, fluorescence microscopy, and molecular biology.
Must posses excellent computer skills and ability to
perform basic quantitative analysis of large data sets.
Knowledge of programs such as Spotfire, PipelinePilot
and GraphPrism would be preferred. More advanced statistics
or programming skills a plus. Excellent critical thinking
skills and attention to detail needed. Must be able
to use sound judgment to effectively solve problems,
work independently, and handle a variety of tasks. Requires
effective oral and written communication skills along
with meticulous laboratory technique and recording skills.
Must be able to use discretion to organize workflow
and to change methodologies to optimize work results
and communicate effectively with all levels of staff
to ensure that work supports team goals.
Interested applicants should send curriculum vitae and
names of three references to:
Dr. Stephen Haggarty, Center for Human Genetic Research,
Massachusetts General Hospital, 185 Cambridge Street,
Boston, MA 02114,
email: haggarty@chgr.mgh.harvard.edu
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