Faculty > Stephen J. Haggarty    
       

Stephen J. Haggarty, Ph.D.

Selected Publications

 
 

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 PUBLICATIONS
 

Haggarty, S.J. & Tsai, L.H. (2011). Probing the role of HDACs and mechanisms of chromatin-mediated Neuroplasticity. Neurobiology of Learning & Memory, 96: 41-52. (PMC Journal - In Process)

Fass, D.M., Shah, R., Ghosh, B., Hennig, K., Norton, S., Zhao, W.N., Reis, S., Klein, P., Mazitschek, R., Maglathlin, R., Lewis, T. & Haggarty, S.J. (2011). Effect of inhibiting histone deacetylase with short-chain carboxylic acids and their hydroxamic acid analogs on vertebrate development and neuronal chromatin. ACS Medicinal Chemistry Letters, 2:39-44. (PMC Journal - In Process)

Pan, J.Q., Lewis, M.C., Ketterman, J.K., Clore, E.L., Riley, M., Richards, K.R., Berry-Scott, E., Liu, X., Wagner, F.F., Holson, E.B., Neve, R.L., Biechele, T.L., Moon, R.T., Scolnick, E.M., Petryshen, T.L. & Haggarty, S.J. (2011). AKT kinase activity is required for lithium to modulate mood-related behaviors in mice. Neuropsychopharmacology, 36:1397-1411. (PMC Journal - In Process)

Kuai, L, Ong, S.E., Madison, J.M., Wang, X, Duvall, J.R., Lewis, T.A., Luce, C.J., Conner, S.D., Pearlman, D.A., Wood, J.L., Schreiber, S.L., Carr, S.A., Scolnick, E.M. & Haggarty, S.J. (2011). Identification of AAK1 as an inhibitor of neuregulin-1/ErbB4-dependent neurotrophic factor signaling using integrative chemical genomics and proteomics. Chemistry & Biology. (manuscript in press).

Kuai, L., Wang, X., Madison, J.M., Schreiber, S.L., Scolnick, E.M, & Haggarty, S.J. (2010). Chemical genetics identifies small-molecule modulators of neuritogenesis involving neuregulin-1/ErbB4 signaling. ACS Chemical Neuroscience, 1:325-342.
PubMed Link

Maze, I.S., Covington, H.E., Laplant, Q.C., Renthal, W., Fass D.M., Haggarty, S.J., Tarakhovsky A. & Nestler, E.J. (2010). Histone methylation in the nucleus accumbens controls behavioral responses to cocaine. Science, 327:213-216.
PubMed Link

Bradner, J.E., West, N., Grachan, M.L., Greenberg, E.F., Haggarty, S.J., Warnow, T. & Mazitsheck, R. (2010). Chemical phylogenetics of histone deacetylases. Nature Chemical Biology, 6:238-243.
PubMed Link

Rihel, J., Prober, D.A., Arvanites, A., Lam, K., Zimmerman, S., Jang, S., Haggarty, S.J., Kokel, D., Rubin, L.L., Peterson, R.T. & Schier, A.F. (2010). Zebrafish behavioral profiling links drugs to biological targets and rest/wake regulation. Science, 327:348-351.
PubMed Link

Bradner, J.E., Mak, R., Tanguturi, S.K., Mazitschek, R., Haggarty, S.J., Ross, K., Chang, C.Y., Bosco, J., West, N., Morse, E., Lin, K., Shen, J.P., Kwiatkowski, N.P., Gheldof, N., Dekker, J., DeAngelo, D.J., Carr, S.A., Schreiber, S.L., Golub, T.R. & Ebert, B.L. Chemical genetic strategy identifies histone deacetylase 1 (HDAC1) and HDAC2 as therapeutic targets in sickle cell disease. Proc. Natl. Acad. Sci. U S A, 28:12617-12622.
PubMed Link

Kilgore, M., Miller, C.A., Fass, D.M., Hennig, K.M., Haggarty, S.J., Sweatt, J.D. & Rumbaugh, G. (2009). Inhibitors of class I histone deacetylases reverse contextual memory deficits in a mouse model of Alzheimer's disease. Neuropsychopharmacology, 35:870-880.
PubMed Link

Covington, H.E., Maze, I.S., LaPlant, Q.C., Vialou, V.F., Yoshinori, O.N., Berton, O., Fass, D.M., Renthal, W., Rush, A.J., Wu, E.T., Ghose, S., Krishnan, V., Russo, S.J., Tamminga, C., Haggarty, S.J. & Nestler. E.J. (2009). Antidepressant actions of HDAC inhibitors. Journal of Neuroscience, 29:11451-11460.
PubMed Link

James, R.G., Biechele, T.L., Conrad, W.H., Camp, N.D., Major, M. M. Sommer, K., Yi X.H., Fass, D.M., Roberts, B., Major, M.B., Cleary, M.A., Arthur, W.T., MacCoss, M., Rawlings, D.J., Haggarty, S.J. & Moon, R.T. (2009). Bruton's tyrosine kinase revealed as a negative regulator of Wnt/ß-catenin signaling. Science Signaling 2:ra25.
PubMed Link

Guan, J.S., Haggarty, S.J., Giacometti, E., Dannenberg, J.H., Joseph N., Gao, J., Nieland, T.J.F., Zhou, Y., Wang, X., Mazitschek, R., Bradner, J.E., DePinho, R.A., Jaenisch, R. & Tsai, L.H. (2009). HDAC2 negatively regulates memory formation and synaptic plasticity. Nature, 459:55-60.
PubMed Link

Mao, Y., Ge, X., Frank, C.L., Madison, J., Koehler, A.N., Doud, M.K., Tassa, C., Berry, E.M., Petryshen, T.L., Soda, T., Biechele, T., Moon, R.T., Haggarty, S.J. & Tsai, L.H. (2009). DISC1 regulates neural progenitor proliferation via modulation of GSK3ß/ß-catenin signaling. Cell, 136:1017-1031.
PubMed Link