| Haggarty, S.J. & Tsai,
L.H. (2011). Probing the role of HDACs and
mechanisms of chromatin-mediated Neuroplasticity.
Neurobiology of Learning & Memory, 96:
41-52. (PMC Journal - In Process)
Fass, D.M., Shah, R., Ghosh, B., Hennig,
K., Norton, S., Zhao, W.N., Reis, S., Klein,
P., Mazitschek, R., Maglathlin, R., Lewis,
T. & Haggarty, S.J. (2011). Effect of
inhibiting histone deacetylase with short-chain
carboxylic acids and their hydroxamic acid
analogs on vertebrate development and neuronal
chromatin. ACS Medicinal Chemistry Letters,
2:39-44. (PMC Journal - In Process)
Pan, J.Q., Lewis, M.C., Ketterman, J.K.,
Clore, E.L., Riley, M., Richards, K.R.,
Berry-Scott, E., Liu, X., Wagner, F.F.,
Holson, E.B., Neve, R.L., Biechele, T.L.,
Moon, R.T., Scolnick, E.M., Petryshen, T.L.
& Haggarty, S.J. (2011). AKT kinase
activity is required for lithium to modulate
mood-related behaviors in mice. Neuropsychopharmacology,
36:1397-1411. (PMC Journal - In Process)
Kuai, L, Ong, S.E., Madison, J.M., Wang,
X, Duvall, J.R., Lewis, T.A., Luce, C.J.,
Conner, S.D., Pearlman, D.A., Wood, J.L.,
Schreiber, S.L., Carr, S.A., Scolnick, E.M.
& Haggarty, S.J. (2011). Identification
of AAK1 as an inhibitor of neuregulin-1/ErbB4-dependent
neurotrophic factor signaling using integrative
chemical genomics and proteomics. Chemistry
& Biology. (manuscript in press).
Kuai, L., Wang, X., Madison, J.M., Schreiber,
S.L., Scolnick, E.M, & Haggarty, S.J.
(2010). Chemical genetics identifies
small-molecule modulators of neuritogenesis
involving neuregulin-1/ErbB4 signaling.
ACS Chemical Neuroscience,
1:325-342.
PubMed
Link
Maze, I.S., Covington, H.E., Laplant, Q.C.,
Renthal, W., Fass D.M., Haggarty, S.J.,
Tarakhovsky A. & Nestler, E.J. (2010).
Histone methylation in the nucleus accumbens
controls behavioral responses to cocaine.
Science, 327:213-216.
PubMed
Link
Bradner, J.E., West, N., Grachan, M.L.,
Greenberg, E.F., Haggarty, S.J., Warnow,
T. & Mazitsheck, R. (2010). Chemical
phylogenetics of histone deacetylases. Nature
Chemical Biology, 6:238-243.
PubMed
Link
Rihel, J., Prober, D.A., Arvanites, A.,
Lam, K., Zimmerman, S., Jang, S., Haggarty,
S.J., Kokel, D., Rubin, L.L., Peterson,
R.T. & Schier, A.F. (2010). Zebrafish
behavioral profiling links drugs to biological
targets and rest/wake regulation. Science,
327:348-351.
PubMed
Link
Bradner, J.E., Mak, R., Tanguturi, S.K.,
Mazitschek, R., Haggarty, S.J., Ross, K.,
Chang, C.Y., Bosco, J., West, N., Morse,
E., Lin, K., Shen, J.P., Kwiatkowski, N.P.,
Gheldof, N., Dekker, J., DeAngelo, D.J.,
Carr, S.A., Schreiber, S.L., Golub, T.R.
& Ebert, B.L. Chemical genetic strategy
identifies histone deacetylase 1 (HDAC1)
and HDAC2 as therapeutic targets in sickle
cell disease. Proc. Natl. Acad.
Sci. U S A, 28:12617-12622.
PubMed
Link
Kilgore, M., Miller, C.A., Fass, D.M.,
Hennig, K.M., Haggarty, S.J., Sweatt, J.D.
& Rumbaugh, G. (2009). Inhibitors of
class I histone deacetylases reverse contextual
memory deficits in a mouse model of Alzheimer's
disease. Neuropsychopharmacology,
35:870-880.
PubMed
Link
Covington, H.E., Maze, I.S., LaPlant, Q.C.,
Vialou, V.F., Yoshinori, O.N., Berton, O.,
Fass, D.M., Renthal, W., Rush, A.J., Wu,
E.T., Ghose, S., Krishnan, V., Russo, S.J.,
Tamminga, C., Haggarty, S.J. & Nestler.
E.J. (2009). Antidepressant actions of HDAC
inhibitors. Journal of Neuroscience,
29:11451-11460.
PubMed
Link
James, R.G., Biechele, T.L., Conrad, W.H.,
Camp, N.D., Major, M. M. Sommer, K., Yi
X.H., Fass, D.M., Roberts, B., Major, M.B.,
Cleary, M.A., Arthur, W.T., MacCoss, M.,
Rawlings, D.J., Haggarty, S.J. & Moon,
R.T. (2009). Bruton's tyrosine kinase revealed
as a negative regulator of Wnt/ß-catenin
signaling. Science Signaling 2:ra25.
PubMed
Link
Guan, J.S., Haggarty, S.J., Giacometti,
E., Dannenberg, J.H., Joseph N., Gao, J.,
Nieland, T.J.F., Zhou, Y., Wang, X., Mazitschek,
R., Bradner, J.E., DePinho, R.A., Jaenisch,
R. & Tsai, L.H. (2009). HDAC2 negatively
regulates memory formation and synaptic
plasticity. Nature, 459:55-60.
PubMed
Link
Mao, Y., Ge, X., Frank, C.L., Madison,
J., Koehler, A.N., Doud, M.K., Tassa, C.,
Berry, E.M., Petryshen, T.L., Soda, T.,
Biechele, T., Moon, R.T., Haggarty, S.J.
& Tsai, L.H. (2009). DISC1 regulates
neural progenitor proliferation via modulation
of GSK3ß/ß-catenin signaling.
Cell, 136:1017-1031.
PubMed
Link
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