Faculty > Jose C. Florez.    
       

Jose C. Florez, M.D., Ph.D.

Selected Publications

1. Florez JC, Burtt N, de Bakker PIW, Almgren P, Tuomi T, Homkvist J, Gaudet D, Hudson TJ, Schaffner SF, Daly MJ, Hirschhorn JN, Groop L, Altshuler D. Haplotype structure and genotype-phenotype correlations of the sulfonylurea receptor (SUR1) and the islet ATP-sensitive potassium channel (Kir6.2) gene region. Diabetes 2004;53:1360-1368. (PMID: 15111507).
 
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2. Florez JC, Jablonski KA, Bayley N, Pollin TI, de Bakker PIW, Shuldiner AR, Knowler WC, Nathan DM, Altshuler D, for the Diabetes Prevention Program Research Group: TCF7L2 polymorphisms and progression to diabetes in the Diabetes Prevention Program. N Engl J Med 2006;355:241-250. (PMID: 16855264).

3. The Diabetes Genetics Initiative of Broad Institute of Harvard and MIT, Lund University and Novartis Institutes for BioMedical Research. Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science 2007;316:1331-1336. (PMID: 17463246).

4. Florez JC, Manning AK, Dupuis J, Gianniny L, Irenze K, McAteer J, Mirel DB, Fox CS, Cupples LA, Meigs JB. A 100K genome-wide association scan for diabetes and related traits in the Framingham Heart Study: Replication and integration with other genome-wide datasets. Diabetes 2007;56:3063-3074. (PMID: 17848626).

5. Moore AF, Jablonski KA, McAteer JB, Saxena R, Pollin TI, Franks PW, Hanson RL, Shuldiner AR, Knowler WC, Altshuler D, Florez JC for the Diabetes Prevention Program Research Group. Extension of type 2 diabetes genome-wide association scan results in the Diabetes Prevention Program. Diabetes 2008;57:2503-2510. (PMID: 18544707).

6. Meigs JB, Shrader P, Sullivan LM, McAteer JB, Fox CS, Dupuis J, Manning AK, Florez JC, Wilson PF, D’Agostino RB, Cupples LA. Genotype score in addition to common risk factors for prediction of type 2 diabetes. N Engl J Med 2008;359:2208-2219. (PMID: 19020323).

7. Dupuis J*, Langenberg C*, Prokopenko I*, Saxena R*, Soranzo N*, (…), Boehnke M†, McCarthy MI†, Florez JC† and Barroso I† for the MAGIC investigators. New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet 2010;42:105-116. (PMID: 20081858).

8. Ingelsson E*†, Langenberg C*, Hivert M-F*, (…), Groop L†, Watanabe RM†, Florez JC† on behalf of the MAGIC investigators. Detailed physiologic characterization reveals diverse mechanisms for novel genetic loci regulating glucose and insulin metabolism in humans. Diabetes 2010;59:1266-1275. (PMID: 20185807).

9. Jablonski KA, McAteer JB, de Bakker PIW, Franks PW, Pollin TI, Hanson RL, Saxena R, Fowler S, Shuldiner AR, Knowler WC, Altshuler D, Florez JC for the Diabetes Prevention Program Research Group. Common variants in 40 genes assessed for diabetes incidence and response to metformin and lifestyle interventions in the Diabetes Prevention Program. Diabetes 2010;59:2672-2681. (PMID: 20682687).

10. Soranzo N*, Sanna S*, Wheeler E*, Gieger C*, Radke D*, (…), Florez JC†, Uda M†, Wareham NJ†, Barroso I†, Meigs JB†. Common variants at ten genomic loci influence hemoglobin A1C levels via glycemia and non-glycemic pathways. Diabetes 2010;59:3229-3239. (PMID: 20858683).

11. Walford GA, Florez JC. Type 2 diabetes and genetics, 2010: Translating knowledge into understanding. Curr Cardio Risk Rep 2010;4:437-445.

12. Billings LK, Florez JC. The genetics of type 2 diabetes: What have we learned from GWAS? Ann NY Acad Sci 2010;1212:59-77. (PMID: 21091714).

13. Hivert M-F, Jablonski KA, Perreault L, Saxena R, McAteer JB, Franks PW, Hamman RF, Kahn SE, Haffner S, the DIAGRAM Consortium, Meigs JB, Altshuler D, Knowler WC, Florez JC for the Diabetes Prevention Program Research Group. An updated genetic score based on 34 confirmed type 2 diabetes loci is associated with diabetes incidence and regression to normoglycemia in the Diabetes Prevention Program. Diabetes 2011 (in press).

14. Wang TJ, Larson MG, Vasan RS, Cheng S, Rhee EP, McCabe E, Lewis GD, Palma M, Hardy G, Kristo F, Palma A, Fox CS, Jacques PF, Fernandez C, O’Donnell CJ, Carr SA, Mootha SK, Florez JC, Souza A, Melander O, Clish CB, Gerszten RE. Metabolite profiles and the risk of developing diabetes. Nat Med 2011 (in press).

15. Rhee EP, Cheng S, Larson MG, Walford GA, Lewis GD, McCabe E, Yang E, Farrell L, Fox CS, O’Donnell CJ, Carr SA, Vasan RS, Florez JC, Clish CB, Wang TJ, Gerszten RE. Lipid profiling identifies a triacylglycerol signature of insulin resistance and improves diabetes prediction in humans. J Clin Invest 2011 (in press).

For Pubmed Bibliography: click here