Facilities & Resources

     
The Beagle Genome Annotation Database
Beagle is a human-centered database designed as a tool for biological discovery and exploration. The 2.4 GB database, which includes build-in software, has records for all ~245,000 Homo sapiens, Pan troglodytes, Canis lupus familiaris, Mus musculus, Danio rerio, Drosophila melanogaster, Caenorhabditis elegans, Saccharomyces cerevisiae, and Schizosaccharomyces pombe genes.

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CHGR Clinical Genetic Research Facility
The facility's primary mission is to support and promote genetic clinical research. It provides an infrastructure and space where clinical investigators can study disease states and collect specimens for their genetic research.

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CHGR DNA and Tissue Culture Resource
This facility provides processing of cell lines, human blood and tissue samples for DNA, plasma and buffy coat storage and for initiation of lymphoblast and fibroblast cell lines in furtherance of the CHGR mission to promote the use of genetic strategies in basic and clinical research.

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CHGR Genotyping Resource
Genotyping is performed for determining genetic variation in man and mouse, of interest for studies of human health and disease.

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CHGR Monoclonal Antibody Production Facility
This Facility provides a monoclonal antibody production service to research projects. Protein/peptides provided by the individual investigators will be used to generate mouse monoclonal antibodies.

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              C57BL/J



                 A/J
CHGR Chromosome Substitution Strain (CSS) Resource
The C57BL6/J and A/J strains exhibit inherited variation in many phenotypes of interest for human disease, including physiology, metabolism, susceptibility or resistance to spontaneous diseases, such as arthritis, atherosclerosis and cancer, as well as differences in susceptibility or resistance to infection and inflammation.

A panel of 22 related inbred C57BL/6 lines each homozygous for a different A/J chromosome (19 autosomes, X, Y, mitochondria), called a chromosome substitution strain set, provides a tool for studies, to identify genetic variation that contributes to complex phenotypes of interest to human health and disease.

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