 For Appointments
617-724-1700
Fax
617-724-3895
Office Address
Massachusetts General Hospital Cancer Center
Division of Surgical Oncology
55 Fruit Street, YAW 7
Boston, MA 02114
Clinical Interests
Gastrointestinal Cancer (Stomach, Colon, Rectum, Anus); Hepatobiliary Cancer (Liver, Bile Duct, Pancreas); Experimental Therapeutics; Melanoma
Laboratory Interests
Cusack Laboratory
Education
MD Degree: Emory University School of Medicine, Atlanta, Georgia, 1986
Postdoctoral Training
Resident: General Surgery, Tufts-New England Medical Center, Boston, MA
Fellow: Surgical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX
Board Certification
American Board of Surgery, 1993
Academic Appointments
Assistant Professor of Surgery, Harvard Medical School
Program/Specialty
Colorectal; Liver
Language:
German
Awards and Honors
National Research Service Award
MD Anderson Clinical Fellows Research Award
National Research Service Award
Clinical Oncology Fellowship Award, American Cancer Society, Texas Division
MD Anderson Clinical Fellows Research Award
American Cancer Society Clinical Oncology Career Development Award
UNC Lineberger Comprehensive Cancer Ctr Clinical/Translational Research Award
NIH Shannon Award
My Publications
Link to PubMed Database
Selected Publications (From a list of 47 publications)
Cusack, JC, Fuhrman, GM, Lee, JE, and Evans, DB. Managing unsuspected tumor invasion of the superior mesenteric-portal venous confluence during pancreaticoduodenectomy. Am J Surg, 1994; 168:1-3.
Fuhrman, GM, Leach, SD, Staley CA, Cusack, JC, Charnsangavej, C, Cleary KR, El-Naggar, AK, Fenoglio CJ, Lee, JE, Evans, DB. Rationale for en-bloc vein resection in the treatment of pancreatic adenocarcinoma adherent to the superior mesenteric-portal vein confluence. Ann Surg. 1996; 223(2):154 -162.
Cusack, JC, Giacco, GG, Cleary, K, Davidson, BS, Izzo, F, Skibber, J, Yen, J, Curley, SA. Survival factors in 186 patients under 40 years old with colorectal adenocarcinoma. J Am Coll Surg, 1996;183(2):105-112.
Evans, DB, Lee, JE, Leach, SD, Fuhrman, GM, Cusack, JC, Rich,TA. Vascular resection and intraoperative radiation therapy during pancreaticoduodenectomy: rationale and technique. Advances in Surgery, 1996; 29:235-62.
Cusack, JC, Spitz, FR, Nguyen, D, Zhang, WW, Cristiano, RJ, and Roth, JA. High levels of gene transduction in human lung tumors following intralesional injection of recombinant adenovirus. Cancer Gene Therapy, 1996; 3(4): 245-249.
Spitz, FR, Nguyen, D, Skibber, JM, Cusack, JC, Roth, JA, Cristiano, RJ. In vivo adenovirus-mediated p53 tumor suppressor gene therapy for colorectal cancer. Anticancer Res, 1996; 16:3415-3422.
Seymour, JF, Cusack, JC, Lerner, SA, Pollock, RE, Keating, MJ. Case/control study of the role of splenectomy in chronic lymphocytic leukemia. Journal of Clinical Oncology, 1997; 15(1):52-60.
Cusack, JC, Seymour, JF, Lerner, S, Keating, ML, Pollock, RE. Role of splenectomy in chronic lymphocytic leukemia. J Am Coll Surg. 1997;185:237-243.
Wang, C-Y, Cusack, JC, Liu, R, and Baldwin, AS. Control of inducible chemoresistance: enhanced anti-tumor therapy through increased apoptosis by inhibition of NF-*B. Nat Med 1999: 5(4)412-417.
Weston, BW, Hiller, KM, Mayben, JP, Manousos, GA, Bendt, KM, Liu, R, Juliano, RL, and Cusack, JC. Expression of human *(1,3) fucosyltransferase antisense sequences inhibits selectin-mediated adhesion and liver metastasis of colon carcinoma cells. Cancer Res 1999:59:2127-2135.
Cusack, JC, Liu, R, and Baldwin, AS. Inducible chemoresistance to 7-ethyl-10-*4-(1-piperidino)-1-piperidino*-carbonyloxycamptothecin (CPT-11) in colorectal cancer cells and a xenograft model is overcome by inhibition of nuclear factor-*B activation. Cancer Res 2000: 60:2323-2330.A16.
Cusack, JC, Liu, R, Baldwin, AS. NF-*B and chemoresistance: Potentiation of cancer chemotherapy via inhibition of NF-*B. Drug Resistance Updates 1999; 2: 271-273.
Russo SM, Tepper JE, Baldwin AS, Liu R, Adams J, Elliott P, Cusack JC. Enhancement of radiosensitivity by proteasome inhibition: Implications for a role for NF-kB. Int J Rad Onc Biol Phys 2001; 50(1): 183-193.
Cusack JC, Liu R, Houston MA , Abendroth K, Elliott PJ, Adams J, Baldwin AS. Enhanced chemosensitivity to CPT-11 with proteasome inhibitor PS-341: Implications for systemic NF-*B Inhibition. Cancer Research 2001; 61: 3535-3540.
Cusack, J. Overcoming anti-apoptotic responses to promote chemosensitivity in metastatic colorectal cancer to the liver. Adv in Surgery 2002.
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