For Appointments
617-724-4800

Fax
617-726-9418

Office Address
Massachusetts General Hospital
Division of Surgical Oncology
55 Fruit Street, YAW 7
Boston, MA 02114

Clinical Interests
Breast Disease; Breast Cancer;
Hereditary Breast and Ovarian Cancer

Education
MD Degree: Dartmouth Medical School, Hanover, NH, 1979

Postdoctoral Training
Residency: General Surgery, Mercy Hospital, Pittsburgh, PA
Fellowship: Surgical Oncology, National Cancer Institute, Bethesda, MD

Board Certification
Surgery, 1985

Academic Appointments
Assistant Professor of Surgery, Harvard Medical School

Memberships, Offices and Committee Assignments in Private Sector
1992 - Scientific Advisory Board for Continuing Medical Education, Valleylab, Inc., Boulder, CO
1996-1997 - Chairman, Breast Cancer Medical Advisory Board OncorMed, Inc., Gaithersburg, MD
1999- Scientific Advisory Board, Imagyn, Inc., Irvine, CA
1999- - Medical Advisory Board, Assurance Medical, Hopkinton, MA

Memberships, Offices and Committee Assignments in Professional Societies
1981 - American Medical Association
1982 - 1982 American College of Surgeons
1982 - Associate Fellow
1989 - Fellow
1989-1994 Cancer Committee, Massachusetts Chapter
1985 - GI Tumor Study Group Site Visit, Division of Extramural Activities, National Cancer Institute
1987- American Society of Clinical Oncology
1987- National Surgical Adjuvant Project for Breast and Bowel Cancer
1989 - 2000 Principal Investigator, Lahey Clinic
1988 - Special Review Committee of RFA National Collaborative Diagnostic Imaging Trial, National Cancer Institute
1988 - 1989 - American Cancer Society, Sacramento, CA
Professional Education Committee
1988 - 1991 - American Society of Colon and Rectal Surgeons
1989- Cancer and Leukemia Group B (CALGB)
1989 - Breast Surgery Subcommittee
1996-1999 Surgery Committee
1990- Study Chairman Protocol 9343, A study of breast cancer treatment options for women 70 years of age and older
2000- Vice-Chairman, Breast Surgery Subcommittee
1990- New England Cancer Society
1991- Society of Surgical Oncology
1993- Society for the Study of Breast Disease
1993-1994 - Massachusetts Department of Public Health; Breast Cancer Quality Assurance Task Force
1993-1995 - Association of Community Cancer Centers
1993- - Boston Surgical Society
1994- - National Consortium of Breast Centers, Inc.
1994-1998 Chairperson, Breast Center Registry Committee
1995- Trustee-at-Large
1996- Vice President
1995- - National Institutes of Health Alumni Association
1996- - New England Surgical Society

Awards and Honors
1973 - National Merit Scholar
1982 - Laboratory Research Award, Southwestern Pennsylvania Chapter, American College of Surgeons
1983 - Laboratory Research Award
Southwestern Pennsylvania Chapter, American College of Surgeons
1995 - Proffered Paper Award, Annual Meeting, The American Society of Breast Disease

Major Hospital Committee Assignments
Longitudinal Medical Record Steering Committee, Massachusetts General Hospital

My Publications
Link to PubMed Database

Hughes KS, Schnaper L, Berry D, Cirrincione C, McCormick B, Smith T, Shank B, Smith BL, Shapiro C, Muss H, Winer E, Wood W, Sugarbaker D, Henderson C, Norton L. A randomized comparison of lumpectomy plus tamoxifen with or without irradiation in women 70 years of age or older with early stage breast cancer. NEJM 351: 971-977.

Hughes KS, Roche CA, Campbell CT, Siegel N, Salisbury L, Chekos A, Katz MS, Edell E. Prevalence of Family History of Breast and Ovarian Cancer in a Single Primary Care Practice Using a Self-Administered Questionnaire. The Breast Journal 9: 19-25.

Kopans DB, Rafferty E, Georgian-Smith D, Yeh E, D’Alessandro H, Moore R, Hughes KS, Halpern E. A Simple Model Of Breast Cancer Growth May Provide Explanations For Observations Of Apparently Complex Phenomena. Cancer 97( 12): 2951-2959. 2003

del Carmen MG , Hughes KS, Halpern E, Rafferty E, Kopans D, Parisky YR, Sardi A, Esserman L, Rust S, and Michaelson J. Racial Differences in Mammographic Breast Density. Cancer 98(3): 590-596

Euhus DM, Smith KC, Robinson L, Stuky A, Olopade OI,Cummings S, Garber JE, Chittenden A, Mills GB, Rieger P, Esserman L, Crawford B, Hughes KS, Roche CA,Ganz PA, Joyce Seldon, Fabian CJ, Klemp J,Tomlinson G. Pre-test Prediction of BRCA1 or BRCA2 Mutation by Risk Counselors and the Computer Model BRCAPRO. JNCI 94:844-851.

Berry DA, Iversen ES,Gudbjartsson DF, Hiller EH, Garber JE, Peshkin BN, Lerman C, Watson P, Lynch HT, Hilsenbeck SG, Rubinstein WS, Hughes KS, Parmigiani G. BRCAPRO Validation, Sensitivity of Genetic Testing of BRCA1/BRCA2, and Prevalence of Other Breast Cancer Susceptibility Genes. JCO 20:2701-2712.

Michaelson JS Silverstein M, Wyatt J Weber G Moore R Kopans DB, Hughes, K. Predicting the survival of patients with breast carcinoma using tumor size. Cancer 95:713-23.

Mackarem G, Roche CA, Hughes KS: The Effectiveness of the Gail Model in Estimating Risk for Development of Breast Cancer in Women Under 40 Years of Age. Breast Journal, 7:1 34-39 (2001)

Mackarem G, Roche CA, Hughes KS: The Effectiveness of the Gail Model in Estimating Risk for Development of Breast Cancer in Women Under 40 Years of Age. In: Breast Journal

Shuster TD, Girshovich L, Whitney TM, Hughes KS: Multidisciplinary Care for the Breast Cancer Patient. Surg Clin NA, 80: 505-534.

Hughes KS, Papa MZ, Whitney T, McLellan R: Prophylactic Mastectomy and Inherited Cancer Predisposition. Cancer, 86:1682-1696.

Roche CA, Lucas MR, Hughes KS: Development of a Risk Assessment Clinic. In: Management of Women at High Risk for Breast Cancer. Blackwell Science, Inc. 1999

Levine A, Hughes KS: Cost-Effectiveness of the Identification of Women at High Risk for the Development of Breast and Ovarian Cancer. In: Management of Women at High Risk for Breast Cancer. Blackwell Science, Inc. 1999.