Oncology News Updates

RNA 'Snippets' Play Big Role In Blood Vessel Formation
Yale Scientists say miRNA might represent target for new cancer therapies.
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Tumor Blood Vessel Cells Are Remarkably Atypical
Tumor-specific blood vessel cells are atypically stem cell-like and have potential to differentiate.
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New cervical cancer test beats pap smear
Identified 88 percent of those who had the cancer-causing lesions with far fewer false positives.
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Velcade Approved For Previously Untreated Multiple Myeloma
Approved Across all Disease Stages for Broad Spectrum of Patients.
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Chemotherapy-Stimulated Tumor Recovery Impeded By Anti-Angiogenic Drugs
Mechanism whereby chemotherapy may assist rapid regrowth of tumors after treatment.
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Many cancer patients receive insufficient pain management therapy
Not adequate for the pain caused by their disease or treatments.
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How to differentiate benign from malignant bile duct strictures?
15% patients with presumed malignancy were ultimately found to have benign strictures.
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FivePrime Initiates Phase I Clinical Trial of FP-1039
Study Treats Patients with Advanced Cancers.
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Common painkillers lower levels of prostate cancer biomarker
Impact on a man's risk for getting prostate cancer is unclear, physicians say.
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Protein 'switch' suppresses skin cancer development
When IKK alpha fails to keep cell replacement cycle in balance, cancer follows.
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Progenics Initiates Phase 1 Clinical Study of Targeted Therapy for Prostate Cancer
Monoclonal Antibody-Drug Conjugate Selectively Targets Cancer Cells.
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Elan and Biogen Idec Initiate First Clinical Trial of Tysabri in Oncology
Study in patients with relapsed or refractory multiple myeloma.
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1 step back ... 2 steps forward
Early phase breast cancer study at GUMC suggests new approach can re-sensitize tumors.
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African-Americans have unique lung cancer risks from chronic obstructive pulmonary disease
MD Anderson Cancer Center developed risk prediction assessment.
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Computerized reminder system drove up colon cancer screening rates
System can help doctors manage chronic diseases, annual screenings.
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Collaboration between researchers yields more comprehensive portrait of brain cancer
Comprehensive analysis of genomic variation in the brain cancer glioblastoma.
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Unsuccessful drug against anxiety opens a novel gateway for the treatment of cancer
Siramesine produces phosphatic acid, a phospholipid constituent of cellular membranes.
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Potential remedy for the ‘mental fog’ in cancer patients
Study suggests a possible way to offset chemobrain memory loss .
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OncoMune Publishes Positive Results of OCM-8054
Breast Cancer Dependency on BORIS Unequivocally Demonstrated by RNA Interference.
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Down-staged liver cancer associated with good post-transplant outcomes
Patients can become viable candidates for transplantation if tumors respond to treatment.
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Numerous Undiscovered Gene Alterations In Pancreatic And Brain Cancers Detected
Multitude of broken, missing, and overactive genes found.
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Cytopia Commences Second Phase II Study in Brain Cancer
CYT997 - a novel vascular-disrupting anticancer agent in patients with an aggressive form GBM.
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Results of Phase 2 Trial of HGS-ETR1 With Bortezomib in Advanced Multiple Myeloma
Drug was well tolerated; disease response comparable vs. bortezomib alone.
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Racial disparities seen in U.S. breast cancer care
Doctors are less likely to give black women radiation therapy after surgery.
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Too much calcium in blood may increase risk of fatal prostate cancer
Men in upper range of the normal distribution of serum calcium have almost 3-fold increased risk.
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Height linked to risk of prostate cancer development and progression
Though magnitude of the additional risk of being taller is small.
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Blood 'fingerprints' for cancer
Serum microRNAs can serve as biomarkers for the detection of cancer.
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Scientists produce nanoscale droplets with cancer-fighting implications
Double-emulsions hold potential for targeted drug delivery.
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Oncothyreon announces prioritization plan for development programs
Update on cancer drugs PX-478, PX-866 and Stimuvax(R).
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Study confirms colorectal cancer screening should start at age 50
Colonoscopy best prevention method for colorectal cancer.
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FDA Refuses to File BLA for Cancer Gene Therapy
Novel therapy faces regulatory challenges.
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Oncolytics Biotech Announces US Phase 2 Trial for NSCLC Patients with K-RAS or EGFR-Activated Tumors
Intravenous administration of Reolysin in combination with paclitaxel and carboplatin.
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World Cancer Declaration Sets Ambitious Targets For 2020
Global plan aimed at tackling the growing cancer crisis in developing countries.
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ERBITUX(R) Phase 3 BMS-099 Lung Cancer Study Secondary Endpoint Update:
Overall Survival Results Announced.
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Cyclacel announces recommendations of data review committee for seliciclib Phase 2b NSCLC APPRAISE trial
Drug's safety profile confirmed in a difficult-to-treat patient group.
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FDA Grants Priority Review for Gleevec in GIST
First therapy to be reviewed for use after surgery in kit-positive gastrointestinal stromal tumors.
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Curis Announces Nature Publication on Paracrine Mechanism of Action in Hedgehog-Expressing Tumors
Subsets of colorectal, endometrial, ovarian and pancreatic cancers overexpressed Hedgehog protein.
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Cell Genesys Halts VITAL-2 GVAX Trial in Advanced Prostate Cancer
Trial compared immunotherapy in combination with Taxotere to Taxotere plus prednisone.
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Curis Announces Dosing of First Patient in Phase I Clinical Trial of CUDC-101
First-in-class small molecule drug candidate inhibits EGFR, Her2 and HDAC.
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Randomized Phase 2 Study of IMC-A12 and IMC-1121B for Advanced Prostate Cancer
Studies Commence Patient Enrollment.
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Cancer patients 'not told about new treatments' (UK)
Cancer patients denied information about treatments that could help them live longer.
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Satisfaction and regret after radical prostatectomy procedures studied
New study published in European Urology.
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Eisai's Oral Aloxi Approved For Chemo-Related Nausea/Vomiting
Broadening the company's reach into the CINV market.
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Sniffing out skin cancer by smell
Smell skin gives off could indicate the presence of skin cancers.
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Breastfeeding, other factors may affect risk of breast cancer type
Age at menopause and breastfeeding practices can influence risk of developing the disease.
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Burning incense increases risk of respiratory tract cancers
New analysis is first prospective investigation of incense and cancer risk.
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MMRC Partners With Celgene on Phase I/II Trial of Pomalidomide (CC-4047)
Trial in Relapsed and Refractory Multiple Myeloma Patients.
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CSHL identifies new drug target against virulent type of breast cancer
The enzyme target, Brk, is shown to be an accelerator of HER2-positive tumors.
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AVEO Initiates Phase 1b Combination Trial of AV-951
With FOLFOX6 in Patients with Advanced Colorectal and Other GI Cancers
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Genmab Announces Upcoming Ofatumumab Studies
Front Line CLL, NHL and CLL Retreatment and Japanese Development Studies Planned.
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Normalizing tumor vessels to improve cancer therapy
Researchers explore why tumor blood vessels are abnormal and leaky.
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Hypothyroidism Often Follows Laryngeal Carcinoma Treatment
Undiagnosed hypothyroidism occurred in 28% of patients.
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Long-Term Dysphagia Common in Head and Neck Cancer Patients
In almost 40% of patients who underwent definitive radiotherapy for cancers of the head and neck.
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FDA Grants Fast Track Designation for OGX-011
In combination with docetaxel for progressive metastatic prostate cancer.
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HGS completes enrollment in Phase 2 Trial of HGS-ETR-1 in Non-Small Cell Lung Cancer
Combination study with paclitaxel and carboplatin as first-line therapy.
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Bath Researchers Study How Cancer Cells Come Unstuck
Insight into how cancer cells can break off and spread to other parts of the body.
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American Indians In Northern Plains Have Higher Rates Of Cancer
Compared to those in other regions, Whites.
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Chemokine Therapeutics Receives Approval From Hong Kong to Commence Phase II Study in Liver Cancer
FDA and Health Canada approval for the clinical trial received earlier this year.
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Delcath Expands Phase 3 Trial for Metastatic Melanoma
To Inlcude Swedish Medical Center in Colorado.
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Positive thinking may protect against breast cancer
Feelings of happiness and optimism play role.
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A role for MAPK inhibitors combined with mTORC1 inhibitors
Activation of MAPK pathway encourages cancer cell survival.
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FDA investigates possible Vytorin link to cancer
Studies provide conflicting evidence; FDA says patients should not stop taking Vytorin.
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Why a common treatment for prostate cancer ultimately fails
Hair on a man's head offers clues about versatility of molecule central to disease.
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Drugs to inhibit blood vessel growth show promise in rat model of deadly brain tumor
Glioblastoma tumor size reduced by 50 to 70 percent.
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New Trial to Evaluate Nexavar® as Adjuvant Therapy in Liver Cancer
Enrollment initiated in international phase III study.
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NovaRx Initiates Pivotal Phase III Trial in Lung Cancer
Lucanix® (belagenpumatucel-L) tested in advanced non-small cell lung cancer.
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Bristol-Myers Squibb and PDL BioPharma Enter Global Alliance to Develop Novel Treatment for Multiple Myeloma
Elotuzumab Antibody Designed to Target Highly Expressed Cell Surface Protein.
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New insights into the regulation of PTEN tumor suppression function
Findings identify novel pathway at the root of PTEN alterations in cancer.
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Stanford researchers develop model to find blood biomarkers that estimate tumor size
Correlation of levels of blood biomarkers with cancer volume.
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Statins Don't Cause Cancer in Patients With Low LDL Cholesterol
Significantly increased risk of the disease exists.
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'Cutting by color'
New imaging technique for more precise cancer surgery.
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Obese prostate cancer patients may benefit more from brachytherapy.
Being overweight less of a technical challenges for this type of therapy.
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FDA Questions LabCorp in its Ovarian Cancer Test Service
Company charged for marketing the test without proper clinical validation
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Introgen Therapeutics Announces EMEA Accepts Review of MAA for Advexin(R)
Treatment of recurrent, refractory squamous cell carcinoma of the head and neck.
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AMRI Initiates Phase I Study of Proprietary Oncology Drug Candidate
ALB109564(a), a novel tubulin inhibitor, kills cancer cells by preventing cell mitosis.
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Oncologists Show Support for Erbitux Uptake Based on K-ras Test
Testing of colorectal cancer patients could encourage earlier use of the drug.
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fMRI Becoming Mainstream for Presurgical Mapping of Brain Tumors
Reliable, safe, and effective technique.
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Long-Term BCC Clearance Sustained With Imiquimod
Cream indicated for treatment of superficial basal cell carcinoma and actinic keratosis in adults.
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Bioniche Phase III Clinical Trial in Bladder Cancer Progressing Well
5th Data Safety Monitoring Committee meeting held last week.
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Yakult Honsha to Commence ThermoDox(R) Development Program in Japan
Potential to treat primary liver cancer.
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Synthetic Molecules Could add Spice to Fight Against Cancer
Derivatives of Curcumin kill cancer cells.
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Evidence of activity seen in ASA404 prostate cancer trial
Drug is a small-molecule, tumor vascular disrupting agent.
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Spectrum Pharmaceuticals Launches FUSILEV(TM)
Levoleucovorin for injection - first Proprietary Oncology Drug Approved By The FDA In 2008.
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Prototype test for predicting clinical outcome for melanoma patients
Gene signature prognostication of rapid progression from Stage III to Stage IV.
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Cancer signatures uncovered
Systematic analysis of relationship between neoplastic and developmental transcriptome.
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Progen Resumes Phase I Development of Anticancer Agent
PG11047 evaluated in combination.
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Miraculins to Sell Research Use Kits to Detect PSP94
PSP94 is cancer biomarker that separates benign prostatic hyperplasia specimens from prostate cancer specimens.
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Moisturizers Up Skin Cancer in Mice
4 Commonly Used Moisturizing Creams Promote Tumors in UV-Exposed Mice.
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Tumor Regressions in Relapsed Lymphoma Treated with Blinatumomab
First T cell engaging antibody (BiTE) showing clinical benefit in cancer patients.
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Colon Cancer Linked to Unequal Gene Activity
Subtle difference activity of a pair of genes may be responsible for 1/10 colon-cancer cases.
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Emerging Clinical Data Continues To Support CyberKnife Radiosurgery For The Treatment Of Lung Cancer
Number of lung patients treated has grown by nearly 50 percent.
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Scientists discover major genetic cause of colorectal cancer
Hikes risk of developing cancer to 50 percent.
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Morphotek Announces License Agreement for Development of Monoclonal Antibody to Treat Prostate Cancer
Antibody Binds Novel Target Expressed on Prostate Cancer Cells.
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Tibolone Cuts Fractures and Breast Cancer but Increases Stroke
Drug also appeared to reduce the risk of colon cancer.
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Global Phase 3 Study of IMC-1121B in Metastatic Breast Cancer Commences
First patient treated with anti-VEGFR-2 IgG1 monoclonal antibody.
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Risk assessment plays key role in long-term treatment of breast cancer
MD Anderson-led team finds five-year survivors may benefit from additional therapy.
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Dedicated Breast CT Scanners More Comfortable Than Mammography
Scanners offer 3-dimensional images of the breast.
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Magnetic Resonance Spectroscopy Improves Diagnostic Accuracy in Pediatric Brain Tumors
Noninvasive way of monitoring the biochemical components of normal and abnormal brain tissue.
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Algeta begins first US clinical trial of Alpharadin
Drug used in men with advanced prostate cancer that has metastasized to the skeleton.
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NCI Starts Enrollment in Phase 2 Systemic Melanoma Clinical Trial with Reolysin®
Drug is Oncolytics’ proprietary formulation of the human reovirus.
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Experimental chemotherapy regimen shows promise in treating advanced lung cancer
Promising alternative to standard treatment.
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Breast cancer patients still have risk of relapse after 5 years of systemic therapy
Risk-reduction options for premenopausal women who have completed five years of tamoxifen therapy needed.
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Prostatectomy improves outcome of some men with prostate cancer over watchful waiting
Lower rate of death due to prostate cancer.
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Targeted radiation therapy can control limited cancer spread
Controlled all signs of cancer in 21 percent of patients who had five or fewer sites of metastatic disease.
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Cancer cells with a long breath
Seeking the origin of brain tumours in children.
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Wilex starts patient recruitment in Phase II breast cancer trial with its uPA inhibitor Mesupron(R) (WX-671)
Drug will be given in combination with the chemotherapeutic agent Capecitabine (Xeloda).
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One in five young men checked for prostate cancer
Screening rates in black men are still considered suboptimal.
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Peregrine Pharmaceuticals Doses First Patient in Phase II Trial of Bavituximab in Patients With Advanced Breast Cancer
Company also conducting two other Phase II studies in breast and non-small cell lung cancer.
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Merrimack Pharmaceuticals Initiates Enrollment in a Phase 1 Study of ErbB3 Antagonist
First patient has received an initial dose of MM-121.
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PSA screening may be biased against obese men, leading to more aggressive cancers
PSA levels of obese men tend to be deceptively low.
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First step towards switching off breast cancer and leukaemia
Gab2 operates downstream of a major breast cancer oncogene, Her2.
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Alexion Secures U.S. Patent for ALXN6000, a First-In-Class Anti-CD200 Monoclonal Antibody
Patient Recruitment Continues for Clinical Trial.
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Generex Announces Start of Enrollment in Breast and Ovarian Cancer Trial.
Antigen Express AE37 vaccine derived from the tumor-related HER-2/neu protein.
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Geron Initiates Clinical Trial of GRN163L in Combination with Paclitaxel and Bevacizumab in Patients with Breast Cancer
Fifth Clinical Trial Program for GRN163L.
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FDA Allows Phase 2 Study for Novel Drug to Prevent Chemotherapy Induced Hearing Loss
Sound Pharmaceuticals' trial will enroll 80 patients with Head and Neck and Lung Cancer.
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Researchers discover how tumor suppressor inhibits cell growth
p53 target genes provide an important link between p53 and mTOR, a central regulator of cell growth.
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Zeltia jumps on ovarian cancer drug news
Seeks regulatory approval to use Yondelis to treat ovarian cancer after good final trial results.
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NYU researchers demonstrate activity of mebendazole in metastatic melanoma
Novel assay finds that widely prescribed anti-parasite drug targets cancer-causing protein.
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Pre-cancerous condition linked to chronic acid reflux faces several hurdles
"Barrett's oesophagus" presents unique challenges in diagnosis and treatment.
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InNexus Biotechnology Announces Launch of Large Scale Primate Study of DXL625
Antibody is directed against the B-cell marker CD20.
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Researchers find cancer-inhibiting compound under the sea
Largazole derives from cyanobacteria that grow on coral reefs, targets HDAC.
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Sonus Pharmaceuticals Signs Exclusive In-Licensing Agreement With Bayer Healthcare for Caspase Activator Compounds
Small molecule drugs have been identified in preclinical research as activators of programmed cell death.
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Effect of Lapatinib on the Outgrowth of Metastatic Breast Cancer Cells to the Brain
Reduced occurrence of large brain metastases in mice injected with breast cancer cells that overexpressed HER2.
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Cancer cell growth method spurs hope for children
May speed develoopment of treatment for atypical teratoid/rhabdoid tumors.
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Visualizing the Effects of Treatment in Pediatric Brainstem Glioma Patients
Sequential diffusion tensor imaging visualizes the major brainstem white matter tracts.
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Thin Melanoma Regression Alone Found Insufficient to Order Sentinel Lymph Node Biopsy
More established risk factors include Breslow thickness greater than 1 mm, Clark level IV or V, and lesion ulceration.
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Ariad Starts Phase 2 Clinical Study of Oral Deforolimus in Patients with Advanced Endometrial Cancer
Second Phase 2 clinical trial underway this quarter to evaluate mTOR inhibitor.
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ImClone's Late-Stage Cancer Pipeline Includes a Potential Erbitux Competitor
Lead candidate is an unpartnered angiogenesis inhibitor that targets VEGF-2.
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Diatos Launches Two International Multi-center Phase II Clinical Trials for DTS-201 in Prostate and Breast Cancer
Compounds is a peptidic prodrug of doxorubicin.
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Electro-Optical Sciences Completes Patient Accrual In MelaFind(R) Pivotal Trial For Early Melanoma Detection
Non-invasive, point-of-care instrument designed and developed by EOS to assist in the early diagnosis of melanoma.
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Cancer patients often use "complementary methods"
Patients seek to relieve symptoms and side effects and increase overall wellness.
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Depression Found To Hasten Decline In Cancer Patients
7% increased chance of dying in depressed patients.
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Exposure to Agent Orange linked to prostate cancer in Vietnam veterans
Also greater risks of getting the most aggressive form of the disease.
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New Chemoprevention Gene Therapy That Kills Pancreatic Cancer Cells
VCU Massey Cancer Center and VCU Institute of Molecular Medicine Researchers Publish Findings.
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Turned-off Cannabinoid Receptor Turns On Colorectal Tumor Growth
CB1 Suppresses Tumors, A New Potential Path For Treatment, Prevention
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Immunotherapy Boosts Treatment of Kids' High-Risk Sarcomas
Patients with recurrent or metastatic disease had better-than-normal survival, study finds.
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Robotically-Assisted Operation Performed by Washington University Surgeons
First Kidney Cancer Removal Through Single Belly Button Incision
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Vitamin C may be useful to treat cancer after all
Mice receiving high-dosage injections experienced reduced tumor growth.
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Task Force: Evidence Backs No Prostate Cancer Screening After Age 75 Years
Potential harms associated outweigh any potential benefits.
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YM Biosciences Reports Phase II Data For Nimotuzumab in Metastatic Colorectal Cancer
Overall survival and disease control outcomes, coupled with low toxicity.
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Methadone Breaks Resistance in Untreatable Forms of Leukemia
Surprising killing power against leukemia cells, including treatment resistant forms of the cancer.
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Aegera Initiates a Fifth Phase 1 and 2 Clinical Trial for AEG35156
Drug is a second generation antisense therapeutic targeting XIAP.
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Genmab and GlaxoSmithKline Announce Positive Top-Line Results in Ofatumumab Chronic Lymphocytic Leukemia Pivotal Study
Phase III Pivotal Study of Ofatumumab in Refractory CLL Meets Primary Endpoint.
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MabThera Filed in the EU for Treatment of Most Common Leukemia in Adults
Phase III Study Shows Superior Results for MabThera in CLL When Added to Standard Chemotherapy.
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Prostate Cancer Detection Rate In Patients With Repeated Extended 21-Sample Needle Biopsy
Does one negative extended prostate cancer (CaP) biopsy should reassure patients that they do not have CaP?
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Pathologic T2 Stage Subgroups And Recurrence-Free Survival After Radical Prostatectomy
Pathologic subgroups of stage pT2 do not have prognostic significance.
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Bold cancer therapy begins crucial trials
In human test, world may soon know if the hype about nanoshells was deserved.
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Minorities Less Likely To Know About Breast Cancer Treatment Options
Only 34 percent of African-Americans and 37 percent of Latinas knew their survival odds.
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Digestive Specialists Freeze Out Esophagus Cancer With New Therapy
Cryoablation therapy helps Barrett's esophagus patients with dysplasia.
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Endoscopic circumferential ablation promising for Barrett's esophagus with high-grade dysplasia
90. 2 percent of patients treated were free of HGD at an average of one-year follow-up.
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Preliminary Cerepro Phase III Results Meet Primary Endpoint
Secondary endpoints yet to be established with 45% of patients still alive.
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Ultra-Miniature Bialy-Shaped Particles to Deliver Drugs to Tumor Sites
Alternative to the research group's gadolinium-containing nanoparticles, avoids nephrogenic systemic fibrosis.
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Seattle's Swedish Cancer Institute First in U.S. to Treat Cancer Patient with Elekta VM
Technique delivers a higher dose to the tumor target without compromising coverage and patient safety.
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Infinity Initiates Clinical Development of IPI-493, Its Oral Anti-Chaperone Agent, in Patients With Advanced Solid Tumors
Compound has demonstrated significant oral availability.
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Salvage Surgery Extends Survival of Recurrent Head and Neck Cancer
Should be offered as a potentially curative treatment.
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FDA Flexes New FDAAA Muscle With ESA Safety Labeling
Safety concerns surrounding the use of erythropoiesis-stimulating agents.
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Hollis-Eden Commences Phase I/II Trial with Apoptone(TM) (HE3235) in Late-Stage Prostate Cancer Patients
Small molecule compounds based on endogenous adrenal steroid hormones.
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Ariad Starts Phase 2 Trial of Oral Deforolimus in Patients with Metastatic, Her2-Positive Breast Cancer
Advances milestone in global collaboration with Merck & Co., Inc.
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Elacyt™ Clinical Update
Amendment of clinical program in haematology and solid tumours.
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Exercise Testing for Cancer Fails to Follow Guidelines
Study urges national, international standards to ensure safety, reliable results.
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Modified Salmonella Slows Tumor Growth
Bacteria engineered to express the Fas ligand accumulate in tumors and reduce their growth.
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Mitochondrial DNA Copy Number Associated With Risk Of Kidney Cancer
First molecular epidemiological study to evaluate mtDNA content in lymphocytes as a susceptibility biomarker for cancer
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Mammogram screening methods comparable
Longer screening intervals used by Europeans may be suitable for use in the U.S.
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Japanese Study Identifies Best Approach for Lymphadenectomy in Gastric Cancer
Adding para-aortic nodal dissection to D2 lymphadenectomy does not improve survival or reduce recurrences.
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New treatment for advanced prostate cancer
Using existing prostate cancer drugs in combination with new drugs at lower doses generates better results.
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Millennium Advances Oncology Pipeline
Company initiates trial of first-in-class oncology molecule and progresses Aurora A kinase program.
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Hip Bone Density Helps Predict Breast Cancer Risk
Measuring a woman’s bone mineral density can provide additional information.
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Prostate Cancer Patients Undergoing Hormone Therapy May Experience Cognitive Effects
Ability to recall and concentrate affected.
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Erectile dysfunction drugs allowed more chemotherapy to reach brain tumors in laboratory study
Drugs blocked enzyme and opened blood vessels to tumors but not normal brain.
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NewYork-Presbyterian/Columbia leads research into robotic surgery for kidney cancer
New research helps optimize benefits of robotic approach
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GPC Biotech withdraws European prostate drug filing
European regulators indicate that the application is currently not approvable.
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How molecules out of balance lead to human multiple myeloma and other cancers
Readouts could help in the tailored treatment of patients.
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Rise in Health Care Spending Linked to the Decline in Cancer Mortality in 10 Countries
Reductions in cancer deaths are influenced by increased expenditures on the newer and more costly anticancer drugs.
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Surgery Plus Radiotherapy Plus Chemotherapy Best for Oropharyngeal Squamous Cell Carcinoma.
Longest overall survival when treated by surgery along with adjuvant radiotherapy and chemotherapy.
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Cell Genesys' Final Results From Phase 2 Clinical Trial of GVAX Immunotherapy Published
Second of two Phase 2 clinical trials (G-0010) of GVAX immunotherapy for prostate cancer.
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EpiCept AML Drug Gets "Exceptional Circumstances" Stamp From EU Regulators
Ceplene (histamine dihydrochloride) for remission maintenance and relapse prevention in adults with acute myeloid leukemia.
To read more >>>

Plasma DNA level is a reliable marker of recurrent esophageal cancer, study finds.
Elevated plasma DNA levels occur prior to clinical evidence of recurrence in majority of patients.
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Consortium Develops New Method Enabling Routine Targeted Gene Modification
'Open source' strategy should be valuable tool for genomic research, gene therapy.
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Tumor Growth Significantly Inhibited When Tumor Blood Flow Is Interrupted Following Radiotherapy.
Vascular Disprupting Agent destroyed the microcirculation at any time after the irradiation and inhibited tumor regrowth.
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A new cellular pathway linked to cancer is identified by NYU researchers.
Finding may be used to sensitize cells to chemotherapy.
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JCO Article Highlights CellSearch(TM) Circulating Tumor Cell Test in Treatment of Metastatic Colorectal Cancer
Data Support Prognostic Value of Circulating Tumor Cells.
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Cornerstone Pharmaceuticals Announces Approval to Conduct Phase I/II Clinical Trial of CPI-613 in Cancer Patients by US FDA
First-in-class Altered Energy Metabolism-Directed (AEMD) compound, CPI-613, will be tested in a variety of cancer types.
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Studies conclude impurity in Roche's Viracept did not increase patients' risk of cancer
Confirmation by The European Committee for Human Medicinal Products (CHMP).
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Patient recruitment in Phase II trial with Mesupron(R) (WX-671) in pancreatic cancer patients successfully completed.
Oral drug candidate given in combination with the chemotherapeutic agent Gemcitabine.
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Novel structure proteins could play a role in apoptosis
Two NSP isoforms interact with B23, a multifunctional protein involved in cell division, DNA repair and apoptosis.
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Adenocarcinoma of the Ethmoid Sinus Strongly Related to Wood Dust, Leather Dust
Most patients had been exposed to organic dusts for 25-58 years in their jobs as woodworkers or shoemakers.
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Imiquimod, an immune response modifier, is dependent on the OGF-OGFr signaling pathway.
New insights into a widely used drug that may lead to new agents that will enhance effectiveness and attenuate side-effects.
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Bevacizumab Looks Safe to Add to Modified FOLFOX6 for Colon Cancer
Does not appear to increase the incidence of adverse events that are typically associated with the monoclonal antibody.
To read more >>>

Bradmer Initiates Enrollment in Phase III GLASS-ART Trial in Primary Glioblastoma Multiforme
Monoclonal antibody conjugated to Iodine-131, used as front-line therapy GBM.
To read more >>>

Advexin Shows Significant Six-Month and Overall Survival Benefit over Methotrexate in Prospectively Defined Biomarker Patient Population
Supplemental Findings Presented at AACR's Cancer Clinical Trials and Personalized Medicine Conference
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NEJM Publishes Nexavar Study Demonstrating Significant Improvement in Overall Survival in Patients With Liver Cancer
Nexavar is First Approved Systemic Therapy to Treat the Disease.
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Sound Pharmaceuticals Files Second IND for the Prevention of Chemotherapy-Induced Hearing Loss in Advanced Stage Cancer
SPI-3005 to be tested in advanced stage lung and head and neck cancer patients receiving platinum-based chemotherapy.
To read more >>>

Merck Serono Receives European Approval for Broader Usage of Erbitux in Metastatic Colorectal Cancer
Including First-Line Treatment.
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Progen Terminates Pathway Phase III Trial
Company confirms Focus on Potential High Value Molecules.
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Surgery Could Accelerate Tumor Growth.
While surgery can be very beneficial in cancer, it may also have detrimental effects for some patients.
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Cetuximab Plus Bevacizumab With Chemo Shortens Progression-Free Survival in Advanced Colorectal Cancer
Results of the CAIRO2 study.
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Dendreon Expects Interim Data Analysis for Phase 3 Provenge IMPACT Trial in October
Immunotherapy for Prostate AdenoCarcinoma Treatment (also known as D9902B) clinical trial.
To read more >>>

Prostate Cancer Drug Hailed as Breakthrough
After treatment with abiraterone tumors shrank in almost 80% of men on initial trials.
To read more >>>

Methylgene and Celgene Announce Precuationary Suspension of New Enrollments into MGCD0103 Clinical Trials
Recommendation of a standing internal safety committee halts study.
To read more >>>

Head And Neck Cancer: Quick Way To Determine If Cancer Has Spread
PET-CT scanner can be used as a stand-alone tool to detect secondary cancers
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Rexahn Pharmaceuticals Receives U.S. Patent For New Cancer Compounds
Targeted, small molecule quinazoline analogues inhibit key molecules such as c-Fos and Akt proteins.
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PhiloGene Announces that VEGFb(TM) has been Granted Orphan Drug Designation by the FDA for the Treatment of Advanced Melanoma
Approval includes melanoma in stages IIb through IV.
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Imaging System Offers Glimpse Of Rare Mutant Cells
May Help Understand Origins Of Cancer.
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Halozyme Therapeutics Announces Positive Findings With Pegylated Enzyme in Prostate Cancer Models
Substantial increase in anti-tumor activity in combination with docetaxel (Taxotere) or liposomal doxorubicin (Doxil).
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Tobacco Used To Make Cancer Vaccine
Future of the plant may lie in growing vaccines against cancer
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Over-the-counter Anesthetic Gel Puts the Squeeze on Mammogram Pain
Application of a pain-relieving gel may reduce the breast discomfort.
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Jennerex Publishes Clinical Trial Data With JX-594 Demonstrating Efficacy Against Liver Cancer and Associated Hepatitis B Virus
Study Demonstrates Feasibility and Efficacy of Treating Patients with Primary Liver Cancer.
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Checking More Lymph Nodes Linked to Cancer Patient Survival
May explain why patients at cancer centers and high-volume hospitals live longer.
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New Breast Cancer Test Under Study
Painless, portable device that uses electrical current to look for breast cancer could be an alternative to traditional mammograms.
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GeneNews Launches World's First Blood Test for Colorectal Cancer Screening
Test assesses a patient’s current risk of having colorectal cancer.
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Once Suspect Protein Found to Promote DNA Repair, Prevent Cancer
M.D.Anderson scientists caution against targeting HMGB1 to treat other diseases.
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Cancer Signal Triggers Vytorin Study Review
Patients taking the combination lipid-lowering drug are not at increased risk for cancer despite troubling study data.
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Ambrilia Initiates Phase I/II Clinical Program of its Novel Goserelin Formulation in Prostate Cancer
Next step should greatly enhance the valuation of goserelin formulation.
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Curis Selects Hsp90 Inhibitor CUDC-305 as Development Candidate from Targeted Cancer Drug Development Platform
CUDC-305 meets key preclinical criteria for advancement.
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Exelixis Initiates Phase 3 Trial of XL184 in Medullary Thyroid Cancer
Agent is small molecule anticancer compound targeting the MET, RET, and VEGFR2 receptor tyrosine kinases.
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Repros Therapeutics Inc. Announces That Initial Findings for Proellex® Show No Tumorigenic Response
Two-year Carcinogenicity Study in Rats conducted
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Biovest Reports Results for Patients Treated with Anti-Cancer Vaccine
BiovaxID Demonstrates Clinically and Statistically Significant Improvement of Disease-Free Survival in NHL.
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New Research From Rhode Island Hospital May Help Predict Outcomes For Stomach Cancer Patients
Molecular Markers gastrokine 1 and 2 (GKN1 and GKN2) are produced by normal stomach cells.
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Pediatric Cancer Foundation Launches Clinical Trials
First clinical trial for treatment of pediatric solid tumors in more than 20 years
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Cancer Drug Resistance
Enzyme Expression Levels Correlated With Chemotherapy Drug Response.
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Bradmer Reports Progression-Free Survival Data From Previous Phase II Glioblastoma Multiforme Trials
Data exceed the results achieved in any other clinical trial in newly-diagnosed GBM.
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Using Magnetic Nanoparticles To Combat Cancer
Particles capture free-floating cancer cells and take them out of the body.
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ASA404 Programme to Expand with New Pivotal Trial in Lung Cancer
ATTRACT-2 study will evaluate ASA404 as second-line treatment.
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New Approach to Cancer
Find most tightly controlled genes.
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Cancer Researchers Call for Ethnicity to be Taken into Account.
Breast cancer research needs to investigate how a person's ethnicity influences their response to treatment and its outcome.
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Analgesic Drugs Don't Reduce Ovarian Cancer Risk
Association observed between acetaminophen and aspirin may actually lead to slightly increased risk of ovarian cancer.
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As Rates Rise, Researchers Find Better Way to Identify Melanoma
IMP-3 is not over-expressed in harmless moles but is increased in the most dangerous types of skin cancer.
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Higher-Dose Prophylactic Cranial Irradiation Worsens Lung Cancer Survival
Does not produce a significant reduction in the incidence of brain metastasis.
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Limited Benefit Seen with Docetaxel and Rapid Androgen Cycling for Prostate Cancer
Study with 100 patients with noncastrate levels of testosterone who had undergone no more than 6 months of hormone therapy.
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Micro-RNAs Could Be Markers for Aggressive Melanomas
Expressed at significantly higher levels in primary malignant melanoma tumor samples than in samples from benign nevi .
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BioNumerik Pharmaceuticals Observes Evidence of a Survival Increase in Lung Cancer Patients Participating in Tavocept™ Clinical Trial
Median survival increase of 6.5 months seen for patients with adenocarcinoma.
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Compugen Planning Proof of Concept Human Trial for Breast Cancer Drug Candidate in 2009
Breast Cancer Study in 2009 for CGEN-50001, a known central nervous system drug.
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Mologen AG: First Patient Enrolled in Clinical Study with Cancer Therapy MGN1703
Drug is based on the DNA immunomodulator dSLIM®.
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Dendreon Initiates Phase 2 Trial of Provenge in Patients with Localized Prostate Cancer Prior to Surgery
NeoACT (NEOadjuvant Active Cellular immunoTherapy), or P07-1 has begun enrolling approximately 40 patients.
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BioAlliance Pharma suspends the Phase II/III trial of doxorubicin Transdrug® in primary liver cancer
Follows advice of Drug Safety Monitoring Board and the Steering Committee
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Tumor-inhibiting Protein Could be Effective in Treating Leukemia
Angiocidin also shown to stimulate the body's immune system.
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Focused Internet Services Provide Better Support to Breast Cancer Patients
Integrated system of internet health resources helps patients more than simply providing a list of URLs to accredited sites.
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Infinity Provides Update On Phase 2 Signal-Finding Clinical Study of IPI-504 in Advanced Prostate Cancer
Further enrollment discontinued.
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Nurse-Delivered Therapy Improves Depression Among Cancer Patients
Therapy delivered to cancer patients by oncology nurses improves cancer-related depression compared with standard therapies.
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MRC Technology and Biolex Therapeutics Successfully Complete Collaboration to Humanize a Novel Antibody Targeting CD20
BLX-301 indicated in NHL and rheumatoid arthritis.
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Cyclacel Study of Seliciclib Synergy with Tarceva and Herceptin in Journal Clinical Cancer Research
Synergistic activity between seliciclib and multiple epidermal growth factor receptor in lung cancer and trastuzumab in breast cancer.
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Colorectal Cancer Screening Rates Still Too Low
Only about half of U.S. men and women 50 and older receive the recommended tests.
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FDA Accepts Genta's NDA Amendment as Complete Response for Genasense Treatment of Chronic Lymphocytic Leukemia
Submission Based on Increased 5-Year Survival in Responding Patients.
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New Flavopiridol Regimen Improves Activity, Safety in Chronic Lymphocytic Leukemia
Experimental agent in relapsed, genetically high-risk CLL.
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Nelarabine Improves Event-Free Survival in High-Risk T-ALL
3-year event-free survival rate of at least 70% when nelarabine was added to intensive chemotherapy.
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Reports of Microangiopathic Hemolytic Anemia Halt Phase II Oncology Drug Study
Toxicity in patients on a combination regimen of bevacizumab and sunitinib led to the termination of Genentech phase II study.
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OncoGenex receives completed SPA for primary registration study of lead drug candidate OGX-011
Agreement reached with FDA on the design of a Phase 3 registration trial.
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Schering's Pegintron Cuts Melanoma Return Risk
Hepatitis C drug Pegintron helps stop the return of melanoma after surgery.
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Magnolia Compound Hits Elusive Target in Cancer Cells
Natural compound from magnolia cones blocks pathway for cancer growth previously considered "undruggable".
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Oxford Biomedica announces DSMB Recommendation for Trovax Phase III TRIST Study
Recommendation that the renal cancer trial should continue but that further vaccinations be discontinued.
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Fewer Americans Are Breathing Secondhand Smoke
Nearly half of nonsmoking Americans are still breathing in cigarette fumes, but since the early 1990s the percentage has declined dramatically.
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ED from Prostate Cancer Hormone Therapy Treatable
Many men receiving androgen deprivation therapy for prostate cancer respond well to erectile dysfunction therapy.
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UCLA Researchers Locate and Image Prostate Cancer as it Spreads to Lymph Nodes
Discovery may lead to more effective diagnostic and therapeutics
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Wilm's Tumor Survivors Have Increased Chance of Second Cancer
British Childhood Cancer Survivor Study looked at the medical history of 1,441 adults.
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Treating Rare Breast Cancer With Radiation Therapy May Lower Recurrence Rate
Patients with Phyllodes Tumors may benefit from receiving radiation therapy in addition to surgery.
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Experimental Agent Denosumab Active Against Giant Cell Tumor of Bone
87% of patients had a significant tumor response to the humanized monoclonal antibody.
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UGA Researchers Discover Mechanism that Explains How Cancer Enzyme Winds Up on Chromosomes
Mechanism explains how two essential components of human telomerase are "recruited" from distinct sites in the cell to the telomere.
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Comparison of Angiogenesis-related Factor Expression in Primary Tumor Cultures
Expression levels greater under hypoxic conditions than under normoxia.
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Cancer Drug Shows Promise Against Graft vs. Host Disease
HDAC inhibitors provide novel way to treat major complication of bone marrow transplants, as well as autoimmune diseases.
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Adding Gefitinib to Anastrozole Delays Progression of Metastatic Breast Cancer
Doubled progression-free survival in postmenopausal women with newly diagnosed, hormone receptor-positive metastatic breast cancer.
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MRI Detects Mammographically Occult Breast Cancer in Women Aged 70 and Older
MRI detected a contralateral cancer even when mammography and palpation failed to do so.
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Phase III Trial Supports Continuing Trastuzumab Beyond Breast Cancer Progression
Does not confer undue toxicity.
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FDA Grants Epeius Biotechnologies' Rexin-G a Third Orphan Drug Designation
Treatment of soft tissue sarcomas.
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Mitochondrial cholesterol makes response to chemotherapy difficult in hepatic cancer
Plays key role in the resistance to cytotoxic agents acting via mitochondrion, including doxorubicin.
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GlobeImmune and NIH to Develop Cancer Therapeutics
Company will utilize proprietary Tarmogen® technology to develop multiple immunotherapy products expressing various cancer antigens.
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Molecule targets kidney cancer cells
Drug created from this molecule would help fight the life-threatening disease while leaving patients' kidneys intact.
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Recruitment Completed in Ofatumumab CLL Front Line Study
56 patients in study of ofatumumab in combination with fludarabine and cyclophosphamide to treat CLL in previously untreated patients.
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ValiRx Acquires Global Rights to Novel Compound Targeted at Prostate Cancer
Licence Agreement with Cancer Research Technology Limited to evaluate a novel prostate cancer compound (VAL201).
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Merck Serono: Erbitux® Phase III Clinical Study in Gastric Cancer Started
First patient enrolled in Phase III gastric cancer clinical study, EXPAND (Erbitux in combination with Xeloda and cisPlatin in AdvaNceD esophago-gastric cancer)
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Treatment Delays Result In Poor Outcomes For Men With Breast Cancer
Men who develop breast cancer are often not treated until the disease has spread to the point that treatment becomes difficult.
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Thickness, Location Predict Skin Cancer's Spread
The thicker the skin cancer tumor, the more likely it will spread or recur.
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Awareness of Epidemiology's Limitations Could Reduce Impact of False-positive Cancer Results
Researchers should use more exacting standards when interpreting and reporting results.
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Previously Found Cancer-Promoting Protein in Animal Model Shown to Act as Tumor Suppressor in Cell Culture
A protein thought to promote colorectal cancer in animal models actually suppresses the growth of human cancer cells in culture.
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Single-nucleotide Polymorphisms Do Not Improve Risk Prediction for Breast Cancer
SNPs associated with small but statistically significant increase in the risk of breast cancer do not appear to substantially predict an individual's risk.
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Patients Unaware of Link between Smoking and Bladder Cancer
Better counseling by physicians is necessary.
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Argyrin: Natural Substance Raises Hope for New Cancer Therapies
Scientists at HZI, MHH and LUH publish previously-unknown chemical mechanism
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ImmunoGen, Inc. Announces Start of IMGN388 Clinical Testing
Company announced patient dosing in Phase I clinical trial with targeted anticancer compound for the treatment of solid tumors.
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Preoperative Radiation Impairs Postoperative Bowel Function in Rectal Cancer Patients
Patients with low rectal cancer who underwent long-course radiation before restorative surgery experienced significantly worse bowel function postoperatively.
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pSivida Corp: BrachySil™ Pancreatic Cancer Trials Commence
Phase IIb clinical trial with BrachySil™ (P32 BioSilicon™) as a potential new brachytherapy treatment for inoperable pancreatic cancer
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Oncogenex Increases Economic Interest in Lead Cancer Drug OGX-011
OncoGenex Technologies Inc. and Isis Pharmaceuticals, Inc have amended their agreement and OncoGenex has elected to independently develop its lead cancer drug OGX-011.
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Lorus Therapeutics Publishes Demonstrating Encouraging Results with LOR-2040 with Cytarabine in Patients with AML
Study also points to potential of pre-treatment R2 levels as a possible predictor of clinical activity.
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Peregrine Pharmaceuticals Reports Positive Early Results in Phase II Study of Bavituximab in Breast Cancer
Pre-Specified Primary Efficacy Endpoint Met in Stage 1 of Two-Stage Study.
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Circulating Tumor Cells Reveal Insights Into Lung Cancers
Technology could one day help tailor treatments to individual patients, study says.
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SuperGen - Preliminary Efficacy Update on EORTC Phase 3 Trial of Dacogen vs Supportive Care in Myelodysplastic Syndromes
The company commented on the preliminary efficacy data from a trial comparing Dacogen for Injection to best supportive care in elderly patients with MDS.
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VGX Pharmaceuticals Receives FDA Approval of IND for Novel DNA Vaccine for Cervical Cancer Therapy
The Company expects to initiate the Phase I clinical study for VGX-3100 in patients in a multi-center study in the third quarter of 2008.
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Determining Genetic Signature of Lung Tumors Can Help Guide Treatment
First US clinical trial using genetic screening to identify lung tumors to respond to targeted therapies.
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Merck Receives FDA "Complete Response" on Gardasil
Two supplemental BLAs seeking approval in women ages 27 to 45 and for cross-protection.
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Symptom Screening Plus A Simple Blood Test Improves Early Detection Of Ovarian Cancer
May improve the early detection of ovarian cancer by 20 percent.
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Crucial Factors in Lymphoma Development and Survival Discovered
Researchers at National Jewish Medical and Research Center have discovered an important factor in the development of B-cell lymphomas.
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A Shot in the Arm Against Breast Cancer
A breast cancer vaccine currently being tested in a Phase II trial has demonstrated to be safe and well tolerated in patients.
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Study Evaluates Factors Associated with Racial Disparities in Colon Cancer Screening
Blacks and Hispanics appear less likely to undergo colorectal cancer screening than whites because of socioeconomic, health care access and language barriers.
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Cervarix Wins Tender for UK National Immunisation Program
GSK’s cervical cancer vaccine, Cervarix TM, was confirmed as the UK Department of Health’s vaccine of choice for its national HPV immunisation program.
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Detection of Rare Tumor Cells in Blood
Mehmet Toner, MD, Daniel A. Haber, MD, PhD and many others from MGH developed circulation tumor cell technology that can reliably identify rare tumor cells that circulate in the blood.
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How EGFR Promotes Skin Cancer
Study reveals how scientists have pinpointed the molecular mechanisms underlying tumour response to EGFR.
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HER-2 Improves Survival in Patients with Breast Cancer Brain Metastasis
Yet, established prognostic factors have not taken HER-2 status into account.
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