Careers Naar Laboratory

Postdoctoral Fellow (1)
A Postdoctoral Fellow position is available at the MGH Cancer Center/Harvard Medical School to investigate molecular mechanisms of gene regulation in normal cells and cancers. Our research is mainly focused on elucidating functions of the human ARC/Mediator family of transcriptional co-activator complexes in different gene expression pathways, such as SREBP regulation of cholesterol and lipids (see Yang et al. 2006, Nature 442:700-4), as well as the NF-kappaB regulator of inflammation and immunity. Other projects available in the Naar laboratory include exploring the role of the SIRT1 deacetylase in modulation of chromatin structures and gene expression programs governing metabolism, development and aging using model systems such as human cells, the worm Caenorhabditis elegans, and the fruitfly Drosophila melanogaster. We also investigate transcriptional programs involved in multidrug resistance (MDR) in S. cerevisiae and pathogenic fungi. These studies utilize both contemporary and state-of-the-art cellular, molecular, and biochemical strategies, such as small interfering RNA/RNAi technologies, whole genome expression analysis with Affymetrix DNA microarrays, chromatin immunoprecipitation (ChIP), tandem mass spectrometry, and high-throghput robotic screening for small-molecule inhibitors of gene regulatory pathways. We are also pursuing collaborative structural studies of activator/co-activator interactions using electron microscopy and NMR. Interested applicants should be highly motivated, have a Ph.D. or M.D. degree, a strong background in biochemistry, molecular biology, or cell biology, and publications in internationally recognized journals.

Contact: Please send a letter stating research interests, a curriculum vitae with past research experience, and contact information for 3 references to: Anders M. Naar, PhD Assistant Professor of Cell Biology Harvard Medical School and Massachusetts General Hospital Cancer Center Building 149, 13th Street, Room 7407 Charlestown, MA 02129 USA E-mail: naar@helix.mgh.harvard.edu

Postdoctoral Fellow (1)
Positions are available at the Massachusetts General Hospital Cancer Center/Harvard Medical School to investigate molecular mechanisms of Eeukaryotic transcriptional regulation. The Naar laboratory is pursuing a number of research directions, including elucidating functions of the human ARC/Mediator family of transcriptional co-activator complexes in different gene expression pathways, such as SREBP regulation of cholesterol and lipids (see Yang et al. Nature 442:700-4, 2006), as well as the NF-kappaB regulator of inflammation, immunity, and cancer. We are also investigating a novel nuclear receptor-like transcriptional program controlling multidrug resistance in S. cerevisiae and pathogenic fungi (e.g. Candida species) (see April 3rd issue of Nature; Thakur et al. Nature 452:604-609, 2008). Other projects available in the Naar laboratory include exploring conserved roles of the SIRT1 deacetylase in modulation of chromatin structure and gene expression programs governing lipid metabolism, differentiation and development, aging, and cancer. We have also identified several novel SIRT1 protein complexes that we are further characterizing using various biochemical and mammalian cell assays, as well as in vivo models such as the the roundworm Caenorhabditis elegans, the fruitfly Drosophila melanogaster, and mice. Our studies utilize both contemporary and state-of-the-art genetic/genomic, cellular, molecular, and biochemical strategies, such as small interfering RNA/RNAi technologies, whole genome expression analysis with Affymetrix DNA microarrays, chromatin immunoprecipitation (ChIP), protein affinity chromatography/tandem mass spectrometry, and high-throughput robotic screening for small-molecule inhibitors of gene regulatory pathways. We are also pursuing collaborative structural studies of activator/co-activator interactions using electron microscopy and NMR. Interested applicants should be highly motivated, have a PhD or MD degree, a strong background in molecular biology, biochemistry, or cell biology, and publications in internationally recognized journals.

Contact: Please send a letter describing your research interests, a curriculum vitae with past research experience, and contact information for at least 3 references to: Anders M. Naar, PhD Assistant Professor of Cell Biology Harvard Medical School and Massachusetts General Hospital Cancer Center Building 149, 13th Street, Room 7407 Charlestown, MA 02129 USA E-mail: naar@helix.mgh.harvard.edu



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