Geriatric Anesthesia Research Unit (GARU)

Summary Science Features

Selected publications:

1. Xie, Z., Moir, RD., Romano, DM., Tesco, G., Kovacs, DM., and Tanzi, RE.: Hypocapnia Induces Caspase-3 Activation
   and Increases Ab Production. Neurodegenerative Disease,
    2004; 1:29-37.
2. Xie, Z., Romano, DM., Kovacs, DM., and Tanzi, RE. Effects of RNAi-mediated silencing of g-secretase complex components on cell sensitivity to caspase-3 activation. Journal of Biological Chemistry, 2004; 279: 34130-34137.
3. Xie, Z., Romano, DM., and Tanzi, RE. Effects of RNAi-mediated silencing of PEN-2, APH-1a, and Nicastrin on wild-type versus FAD mutant forms of presenilin 1. Journal of Molecular Neuroscience, 2005; 25: 67-77.
4. Xie, Z., Romano, DM., and Tanzi, RE. RNAi-mediated silencing of X11a and X11b attenuate Ab levels via differential effects on APP processing. Journal of Biological Chemistry, 2005; 280: 15413 - 15421.
5. Xie Z., Dong Y, Maeda U, Alfille P, Culley DJ, Crosby G, Tanzi RE. The common inhalation anesthetic isoflurane induces apoptosis and increases A? levels. Anesthesiology, 2006; 104:988-994.
6. Romano, DM., Dong, Y., Hiltunen, M. Tanzi, RE. Xie, Z. Effects of lipid cell transfection reagents on APP processing and Ab production. Amyloid-The Journal of Protein Folding Disorders, 2006; 13(2): 86-92.
7. Xie, Z. and Tanzi, RE. Alzheimer's Disease Dementia and Post-operative Cognitive Dysfunction. Experimental Gerontology, 2006; 41: 346 - 359.
8. Xie, Z., Dong, Y., Maeda, U., Moir, R., Inouye, S., Culley, DJ., Crosby, G., Tanzi, RE. Isoflurane-induced apoptosis: a potential pathogenic link between delirium and dementia. Journal of Gerontology: Medical Sciences, 2006; 61(12):1300-6.
9. Xie, Z., Dong, Y., Maeda, U., Moir, R., Xia, W., Culley, DJ., Crosby, G., Tanzi, RE.
   Inhalation Anesthetic Isoflurane Induces a Vicious Cycle of Apoptosis and Ab generation. Journal of Neuroscience; 2007; 27 (6): 1247 - 1254.
10. Culley, DJ., Xie, Z. and Crosby, G. General Anesthetic-Induced Neurotoxicity: An Emerging Problem for the Young and Old? Current Opinion in Anesthesiology; 2007, 20:408-413.
11. Zhang, G., Dong, Y., Zhang, B., Xu Wu, Culley, DJ., Crosby, G., Tanzi, RE, Xie, Z.
    Isoflurane-induced caspase-3 activation is dependent on cytosolic calcium and can be attenuated by memantine. Journal of Neuroscience (In Revision).
12. Zhang, B., Dong, Y., Zhang, G., Moir, RD., Xia, W., Yue, Y., Tian, M., Culley, DJ., Grosby, G., Tanzi, RE., Xie, Z. The inhalation anesthetic desflurane induces caspase activation and increases amyloid-b protein levels under hypoxic conditions. Journal of Biological Chemistry (In press).