Massachusetts General Hospital Department of Anesthesia, Critical Care and Pain Medicine - Pain and Neurosciences Research
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Research Overview

Critical Care Research

Pain and Neurosciences Research

Biomedical Innovation

Ethics and Health Policy

Clinical Research

Grant Funding

 
 

Henry K. Beecher Pharmacology Laboratory

Summary Science Features

Research Strategies and Techniques

To investigate how general anesthetics affect ligand-gated ion channels, we study "artificial synapses" using submillisecond superfusion switching and patch-clamp electrophysiology. The effects of anesthetics on agonist-stimulated currents are analyzed using kinetic models. We also use Xenopus oocytes and two-microelectrode electrophysiology to study drug effects on ion channels with low time resolution. To get information about where anesthetics interact with ligand-gated ion channels to produce their effects, we create structural changes in cloned/expressed ion channels using molecular biological techniques. These mutated channels are investigated using the same electrophysiological techniques used to characterize wild-type receptors.


 
Office Information

Department of Anesthesia,
Critical Care and Pain Medicine
Gray-Bigelow 444
55 Fruit Street
Boston, MA 02114

Public Transportation Access: Yes
Disabled Access: Yes