Massachusetts General Hospital Department of Anesthesia, Critical Care and Pain Medicine - Critical Care Research
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Research Overview

Critical Care Research

Pain and Neurosciences Research

Biomedical Innovation

Ethics and Health Policy

Clinical Research

Grant Funding



Summary Science Features

Sepsis is a devastating consequence of infection that frequently causes shock, dysfunction of organs such as the heart and lungs, and coagulation abnormalities. It is the most common cause of death in non-coronary critical care units.  In sepsis, components of microorganisms activate host inflammatory cells to release inflammatory mediators and factors involved in coagulation, and to express receptors and adhesion molecules responsible for recruiting inflammatory cells into organs.  The Sepsis Laboratory is broadly interested in the interplay between microorganisms and the host innate immune system, and in their relation to sepsis-induced dysfunction of organs and systems.

Office Information

Department of Anesthesia,
Critical Care and Pain Medicine
Gray-Bigelow 444
55 Fruit Street
Boston, MA 02114


Public Transportation Access: Yes
Disabled Access: Yes



Judith Hellman