Muscular Physiology and Pharmacology Research
Inflammatory response and stress signaling have been implicated in many human diseases, including critical illness (e.g., burn injury, sepsis), diabetes, atherosclerosis, neurodegenerative disorders and cancer. Despite the intense investigation for a number of years, two fundamental questions remain to be answered: 1) How does inflammatory response/stress signaling mediate these diseases?; 2) How is inflammatory response/stress signaling initiated and sustained?
Major efforts in our laboratory have been focused to answer these questions so as to contribute to the development of novel preventive and/or therapeutic strategies against human diseases. To this end, we have been clarifying the roles of inducible nitric oxide synthase (iNOS) and protein S-nitrosylation, Sirt family proteins, and protein farnesylation in the pathogenesis of inflammation-involved diseases.