Massachusetts General Hospital Department of Anesthesia, Critical Care and Pain Medicine - Critical Care Research
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Research Overview

Critical Care Research

Pain and Neurosciences Research

Biomedical Innovation

Ethics and Health Policy

Clinical Research

Grant Funding


Muscular Physiology and Pharmacology Research

Summary Science Features

Inflammatory response and stress signaling have been implicated in many human diseases, including critical illness (e.g., burn injury, sepsis), diabetes, atherosclerosis, neurodegenerative disorders and cancer.  Despite the intense investigation for a number of years, two fundamental questions remain to be answered: 1) How does inflammatory response/stress signaling mediate these diseases?; 2) How is inflammatory response/stress signaling initiated and sustained?

Major efforts in our laboratory have been focused to answer these questions so as to contribute to the development of novel preventive and/or therapeutic strategies against human diseases.  To this end, we have been clarifying the roles of inducible nitric oxide synthase (iNOS) and protein S-nitrosylation, Sirt family proteins, and protein farnesylation in the pathogenesis of inflammation-involved diseases.

Office Information

Department of Anesthesia,
Critical Care and Pain Medicine
Gray-Bigelow 444
55 Fruit Street
Boston, MA 02114


Public Transportation Access: Yes
Disabled Access: Yes



J.A. Jeevendra Martyn
Masao Kaneki
Shingo Yasuhara