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Center for Pain Medicine Clinical Research
Overview
The staff of the Massachusetts General Hospital Center for Pain Medicine is committed to advancing our knowledge of the evaluation and treatment of pain through the conduct of well-designed clinical trials. Our staff has led numerous national and international clinical trials evaluating new procedures, devices and medications for the treatment of pain.
Investigators
- James P. Rathmell, MD
- Shihab Ahmed, MD
- Jane Ballantyne, MD
- Gary Brenner, MD, PhD
- Lucy Chen, MD
- Chris Gilligan, MD, MBA
- Padma Gulur, MD
- Ron Kulich, PhD
- Jianren Mao, MD, PhD
- Gary Polykoff, MD
- Milan Stojanovic, MD
Ongoing Trials
| PI |
|
Description |
Status |
| Shihab Ahmed, M.D.
|
1 |
Research project to examine the number or chronic pain
patients versus acute pain patients on the inpatient service, by evaluating
demographics, history of chronic opioid use and substance abuse, in order to
help refine pain center services. |
On-going |
| 2 |
Longitudinal study to confirm the efficacy and side
effects associated with spinal drug delivery in cancer patients with
refractory pain. |
On-going |
| Jane Ballantyne, M.D.,
FRCA
|
1 |
Ketamine Study. A randomized, double
blind, placebo-controlled study to evaluate the efficacy and safety of
PMI-150 to placebo as an analgesic for the treatment of breakthrough pain in
cancer patients.
Co-Investigators: Jianren Mao, MD, PhD; Lucy Chen, MD |
On-going |
| 2 |
Pain in patients after total knee replacement surgery. |
On-going |
| 3 |
Acute Post-operative pain database. Analysis of patient
populations, surgical procedures, analgesic techniques, outcomes and
complications with the goal of improving on acute postoperative pain.
Co-Investigator: James Rathmell, MD
|
On-going |
|
4 |
Neuropathic pain study. A Phase 2, double blind
dose-escalation study of KRN5500 for neuropathic pain in patients with
cancer.
Co-Investigators: Shihab Ahmed, MD |
On-going |
| Lucy Chen, M.D.
|
1 |
Acupuncture
therapy survey. To determine the physician's view on acupuncture. |
On-going |
| 2 |
Opioid therapy
survey. To determine the physician's view on opioid therapy. |
On-going |
| Padma Gulur, MD
|
1 |
(Phase I) Children's computer
assessment of pain. This study uses an electronic questionnaire to study the
applicability and feasibility of a new, hand-held, interactive electronic
computer for measuring pain in children, as compared with the current static,
scaling methods of pain assessment.
|
Phase I complete |
| 2 |
(Phase II) Measuring Children's
Pain and Mood by Facial Expressions |
On-going |
| 3 |
Three-Dimensional Pain Mapping ?
To determine the benefits of using a Three-Dimensional (3-D) Pain Mapping
program for persons with chronic pain to indicate the location, intensity,
and depth of their pain on a three-dimensional model. |
On-going |
| Ronald Kulich, PhD |
1 |
Chronic Opioid Therapy Program. This program aims to
ascertain characteristics that may help providers better assess a patient's
candidacy for a chronic opioid therapy regimen as a viable treatment option
for a chronic pain condition.
Co-investigators: Jane Ballantyne, MD, Gary
Polykoff, MD |
On-going |
| Jianren Mao, M.D., Ph.D.
|
1 |
Pain responses in patients on
long-term opioid therapy for chronic pain: evaluating pain responses in
patients on long-term opiates. This study uses quantitative sensory testing
to measure pain responses in patients on long term opioid therapy compared to
patients not on opioid therapy.
Co-Investigator:
Lucy Chen, MD |
On-going |
| 2 |
Clinical management of
opioid-induced hyperalgesia with Tramadol ER?. This study aims to evaluate
the possible role of Tramadol ER? in managing opioid induce hyperalgesia.
Co-Investigator:
Lucy Chen, MD |
On-going |
| 3 |
Opioid therapy evaluation. A
chart review study to evaluate the relation of opioid therapy to various elements,
such as quality of life. |
On-going |
James Rathmell, MD |
1 |
A phase 3, randomized,
placebo-controlled, double blind study to evaluate the efficacy of a novel
sterile lidocaine hydrochloride monohydrate product in adult subjects. A
study (recently completed) that examined the effectiveness of a novel
lidocaine delivery device on reducing the pain of IV start.
Co-Investigator: Padma
Gulur, MD |
completed |
| 2 |
A Phase I, Multicenter,
Placebo-Controlled, Double-Blind, Randomized, Single Administration Clinical
Trial to Evaluate the Safety and Tolerability of Intradiscal rhGDF-5 for the
Treatment of Early Stage Lumbar Disc Degeneration.
Co-Investigator: Chris
Gilligan, MD, William Palmer, MD |
On-going |
| 3 |
Chronic Pain after Total Knee
and Hip Arthroplasty: a Survey of Present Conditions and Outcomes |
On-going |
| Milan Stojanovic, M.D. |
1 |
Evaluation of lumbar disc height as measured on MRI images
as a predictor of lumbar facet joint related pain, a joint study with MGH
department of radiology.
Co-Investigators: William Palmer, MD, Jai Sethee, MD,
Amanda Barker, MD, Meraj Mohiuddin, MD |
On-going |
For More Information
Patients wishing to get information about clinical trials or to enroll in clinical trials should contact: Naomi Shin, B.A., Clinical Research Assistant, 617-726-5186.
Industry representatives wishing to conduct clinical trials should contact Chris Gilligan, MD, Director of Clinical Trials in Pain.
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Office Information
Department of Anesthesia
and Critical Care
Gray-Bigelow 444
55 Fruit Street
Boston, MA 02114
617-726-3030
Public Transportation Access: Yes
Disabled Access: Yes
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