Massachusetts General Hospital Department of Anesthesia, Critical Care and Pain Medicine - Faculty
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Clifford Woolf, MB, BCh, PhD

Clifford Woolf, MB, BCh, PhD


Director, Neural Plasticity Research Group; Richard J. Kitz Professor of Anesthesia Research, Harvard Medical School

Professional Activities

Our group is devoted to investigating the way in which the functional, chemical and structural plasticity of neurons contributes to adaptive and maladaptive changes in the mammalian nervous system. Our major efforts are devoted to the study of pain, the formation of neural circuits during development and failure of regeneration of the adult CNS. Most of our work is concentrated on primary sensory and spinal cord neurons using a multidisciplinary approach spanning genetics, molecular and cell biology, synaptic electrophysiology, neuroanatomy, integrative systems biology and behavior. We have established several functional and comparative genomic strategies using gain and loss of function approaches to screen for genes involved in neuronal development, pain and regeneration. The group works closely with a wide number of academic groups and the pharmaceutical and biotechnology industry to identify and validate molecular targets for novel analgesics and axonal growth determinants.

Medical Training

University of Witwatersrand, Johannesburg, South Africa


View Publications

Related Links

Neural Plasticity Research Group

Contact Information

Department of Anesthesia, Critical Care and Pain Medicine
Building 149 13th St
Charlestown, MA 02129
Phone: 617-724-3622

Office Information

Department of Anesthesia,
Critical Care and Pain Medicine
Gray-Bigelow 444
55 Fruit Street
Boston, MA 02114

Public Transportation Access: Yes
Disabled Access: Yes