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The Effects of Anorexia Nervosa on Peak Bone Mass

This study examines the effect of low-dose estrogen administration on bone density and bone metabolism in adolescent girls. Anorexia nervosa can cause severe bone loss at an early age, and no treatment has thus far been documented to successfully improve bone mass in this population. The study recruits adolescent girls between the ages of 13 and 18 with anorexia nervosa, as well as healthy, normal weight girls of the same age range. Eligible candidates may enroll in the 18-month long placebo-controlled study consisting of 4 overnight hospital visits and 7 outpatient visits. The study includes bone density and hormonal evaluations, and administration of estrogen (a natural female hormone). Remuneration up to $1050 is offered, as well as free parking at the hospital.
 
For more information, please contact Dr. Madhu Misra by phone: (617) 726-3870
or e-mail:
mmisra@partners.org
 
Osteopenia in Adolescents with Anorexia Nervosa
This screening study evaluates bone loss in boys and girls ages 12-18, and adults ages 18-50, who suffer from anorexia nervosa.  We are investigating the prevalence, causes, and predictors of osteopenia, or bone loss, in the spine, hip, wrist and total body.  The study involves only one visit of approximately 3 hours and includes a bone density test, hormonal evaluation, and nutritional assessment at no cost.
 

For more information, please contact Dr. Madhu Misra by phone: (617) 726-3870
or e-mail:
mmisra@partners.org

 

For additional educational information and resources on anorexia nervosa and bone health, please see the educational information section of this site.