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The Neural Systems Group at Massachusetts General Hospital is devoted to systems-level research in cognitive and computational neuroscience. Our research focuses on neuroimaging technologies (particularly functional magnetic resonance imaging, fMRI, and near-infrared spectroscopy, NIRS), computational and data analysis techniques, and investigations across a wide range of clinical populations (stroke, brain injury, neurointensive care patients).

The Neural Systems Group is involved in a number of specific research projects involving learning, rehabilitation, and technology validation. These include:

Stroke Rehabilitation Study: This study is investigating the use of NIRS and fMRI to evaluate brain activity associated with rehabilitation in individuals with unilateral stroke. Subjects perform various simple motor tasks with the affected arm to help us assess the neural basis of motor control and learning.

Traumatic Brain Injury Study: This is a longitudinal study in which patients with a traumatic brain injury and self-described memory difficulties first undergo fMRI scanning, followed by a series of memory intervention sessions. The goal is to see if brain activity measured with fMRI can be used to help predict outcome from the memory intervention.

Intracranial Pressure Study: This study takes place in the neurointensive care setting and seeks to determine if NIRS can be used as a non-invasive measure of the consequences of elevated intracranial pressure (ICP). If such measures turn out to be sufficiently informative and reliable, NIRS could potentially be used in place of the existing invasive techniques for measuring ICP.

In addition to the patient focus of these studies, these and other research projects also require healthy control subjects. If you are interested in participating in any of these studies, please call 617-724-5550.


Gary Strangman, PhD
Group Director
Publications by Dr. Strangman

Quan Zhang, PhD
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Neural Systems Group