Depression Clinical
and Research Program

• Director
• Associate Directors
• Psychiatrists
• Psychologists
• Administrative Staff
• Program Coordinator
• Research Coordinators
• Previous Staff

Associate Directors

Jonathan E. Alpert M.D., Ph.D.

Dr. Alpert is an Associate Director of the MGH Depression Clinical and Research Program and an Assistant Professor of Psychiatry at Harvard Medical School. He is a co-founder and co-director of the MGH Depression and Anxiety Associates Group Practice and a chairperson of the Partners Human Research Committee (IRB). Dr. Alpert received his B.A. from Yale College, M.D. from Yale University School of Medicine, and Ph.D. in behavioral pharmacology from the University of Cambridge (U.K.). Dr. Alpert has a special interest in pharmacological and other innovative approaches to treatment resistant major depressive disorder, clinical features of depressive subtypes including early onset, anxious, chronic, and atypical depressive subtypes, psychotropic drug metabolism and drug-drug interactions, surrogate biomarkers of response to antidepressants and placebo, behavioral factors concerning offspring of depressed parents, the role of folate, S-adenosyl-methionine (SAMe) and other substrates of one carbon metabolism in the pathophysiology and treatment of depression, and ethical issues in the design and conduct of human studies. Dr. Alpert is an author or co-author of over 80 publications.

Andrew Nierenberg M.D.

Dr. Andrew Nierenberg graduated from the Albert Einstein College of Medicine of Yeshiva University, Bronx, New York. He did his residency in psychiatry at New York University/Bellevue Hospital in New York City, where he became a chief resident, and then went on as a Robert Wood Johnson Clinical Scholar at Yale University to study clinical epidemiology. He continued his trek north to join the faculty at Harvard, and then to direct the Affective Disorders Outpatient Unit at McLean Hospital. Dr. Nierenberg then joined the Psychopharmacology Unit at Massachusetts General Hospital in Boston in 1992 where he is currently Associate Director of the Depression Clinical and Research Program, Medical Director of the Bipolar Programs, and Associate Professor of Psychiatry at Harvard Medical School. His primary interests are treatment resistant depression, management of antidepressant side effects, the longitudinal course of affective disorders, and pharmacoepidemiology.