Associate Directors
Jonathan E. Alpert M.D., Ph.D.
Dr. Jonathan Alpert received his BA and MD from Yale University and his PhD in behavioral pharmacology from the University of Cambridge (UK), where he was a Marshall Scholar. He completed residencies at Boston Children’s Hospital and at McLean Hospital before joining the Depression Clinical and Research Program in 1992 where he is an Associate Director as well as Co-Director of the MGH Depression and Anxiety Associates Group Practice. He is also Associate Chief of the Department of Psychiatry for Clinical Services. He is an Associate Professor of Psychiatry and Co-Director of Medical Student Education in Psychiatry at Harvard Medical School and a chairperson of the Partners Human Research Committee (IRB).
Dr. Alpert’s research interests have included pharmacological and other innovative approaches to treatment-resistant major depressive disorder; clinical features of depressive subtypes; psychotropic drug metabolism and drug interactions; surrogate biomarkers of response to antidepressants and placebo; behavioral factors concerning offspring of depressed parents; the role of folate, S-adenosyl-methionine (SAMe) and other substrates of one carbon metabolism in the pathophysiology and treatment of depression; and ethical issues in the design and conduct of human studies.
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Andrew Nierenberg M.D.
Dr. Andrew Nierenberg graduated from the Albert Einstein College of Medicine of Yeshiva University, Bronx, New York. He did his residency in psychiatry at New York University/Bellevue Hospital in New York City, where he became a chief resident, and then went on as a Robert Wood Johnson Clinical Scholar at Yale University to study clinical epidemiology. He continued his trek north to join the faculty at Harvard, and then to direct the Affective Disorders Outpatient Unit at McLean Hospital. Dr. Nierenberg then joined the Psychopharmacology Unit at Massachusetts General Hospital in Boston in 1992 where he is currently Associate Director of the Depression Clinical and Research Program, Co-Director of the Bipolar Programs, and Professor of Psychiatry at Harvard Medical School. His primary interests are treatment resistant depression, bipolar disorder, and the longitudinal course of affective disorders.