Mass General Hospital, Est. 1811

Depression Clinical
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  • All Current Treatment Studies
  • Studies for depressed patients not taking any antidepressants
    • A Study of Omega 3-EPA vs. DHA Fatty Acids in the Treatment of Major Depression
    • A Double-Blind, Placebo-Controlled Study of the Alternative Therapy S-adenosyl-L-methionine (SAMe) versus Escitalopram in Major Depressive Disorder
    • Magnetic Resonance Scan (MRS) Study for Depressed Participants
    • Ziprasidone Augmentation Study
  • Studies for depressed patients currently taking antidepressants
  • Non-treatment studies
  • Studies for Smoking Cessation & Relapse Prevention
  • Other Studies
  • Psychotherapy Studies

A Study of Omega 3-EPA vs. DHA Fatty Acids in the Treatment of Major Depression

This research study examines the difference in the effectiveness of two natural compounds, EPA and DHA omega-3 fatty acids, in treating major depressive disorder. Both types of omega-3 fatty acids are commonly found in fish oils, such as Salmon, Mackerel and Tuna, as well as other marine sources. It is believed that a deficiency in these omega-3 fatty acids may lead to the development of major depression.

The research study lasts for 8 weeks and involves 4 visits after the screen and baseline visits (biweekly). If eligible, participants will be randomly placed into one of three groups. People in the first group will take 1g/day of EPA omega-3 fatty acid, those in the second group will take 1 g/day of DHA omega-3 fatty acid, and those in the third group will take a placebo (a sugar-like pill with no active ingredient). This research study is double-blind, which means that neither you nor the doctor nor any of the research staff will know which group you are in. At the end of this 8-week period you will be offered 3 months of follow-up care at no cost to you at the Depression Clinical and Research Program.

If interested, please contact Soo at syoun@partners.org or at 617-724- 2936.


We initiate new studies regularly, so please contact us for additional information.

© 2008 The Depression Clinical and Research Program at Massachusetts General Hospital
50 Staniford Street, 4th Floor | Boston, MA 02114 | 1-877-55-BLUES

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