Jonathan E. Alpert, M.D. Ph.D.

Jonathan E. Alpert, M.D. Ph.D. is Assistant Professor in Psychiatry at Harvard Medical School in Boston, Massachusetts. In addition, he is Associate Director of the Depression Clinical and Research Program and Co-Founder and Co-Director of the Depression and Anxiety Associates practice at Massachusetts General Hospital. Dr. Alpert is a chair of the Partners Human Research Committee (Institutional Review Board) as well as the Director of Medical School Education in Psychiatry at Harvard Medical School.

Dr. Alpert earned his B.A. and M.D. from Yale University. He earned a Ph.D. in behavioral pharmacology from the University of Cambridge (U.K.) on a Marshall Scholarship. He completed a residency in Pediatrics at Children's Hospital in Boston and a residency in Psychiatry at McLean Hospital in Belmont, Massachusetts where he was also chief resident of the psychopharmacology program.

He is principal and co-investigator on research studies involving novel and existing approaches to depression treatment, surrogate markers of response to drug and placebo, impact of maternal depression on offspring, and influence of comorbid psychiatric disorders and an early age of onset on clinical features of depression and response to treatment. He is also interested in folate, s-adenosyl-methionine and the one carbon cycle as it relates to depressive disorders and pharmacotherapy. Dr. Alpert is author or co-author of over 80 original reports and reviews and co-editor of the Handbook of Chronic Depression (2003).