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Programs:

Summary

Our research seeks to understand the neural correlates of cognitive and perceptual abnormalities in patients with schizophrenia, with a particular focus on the aberrant memory processing seen in this disorder. Working in collaboration with the Harvard Department of Psychology, the Massachusetts General Hospital Schizophrenia Program, and the Martinos Center for Biomedical Imaging, our work represents a confluence of cognitive psychology and functional neuroimaging. Current projects, funded by both federal grants and private foundations, utilize a multimodal imaging approach, including functional magnetic resonance imaging (FMRI), magnetoencephalography (MEG) and near-infrared spectroscopy (NIRS). The ultimate goal of this work is to develop objective diagnostic and prognostic measures, which, in combination with genetic information, may help to provide better treatment for patients with schizophrenia.

Theme

Investigating the neural basis for the cognitive and perceptual abnormalities seen in schizophrenia.

Current Projects and Funding Sources

  1. Neural correlates of source monitoring in schizophrenia (NIMH)

  2. Hippocampal function in first-degree relatives of patients with schizophrenia (NARSAD)

  3. Hallucination monitoring using near-infrared spectroscopy (CIMIT)
Key Collaborators

MGH Schizophrenia Program (Dr. Donald Goff | Dr. Eden Evins)
Harvard Department of Psychology (Dr. Daniel Schacter)
Martinos Center for Biomedical Imaging (Dr. Bruce Rosen | Dr. Eric Halgren | Dr. Gary Strangman)
McLean Hospital (Dr. Stephan Heckers)

Staff

Anthony P. Weiss, MD, MSc
Laboratory Director
Tel: 617/726-0519, E-mail

Joshua Roffman, MD (Post-doctoral fellow))
Margaret Duff (Research assistant)
Lindsay Jubelt (Medical Student-Doris Duke Scholar)
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Laboratory for the Study of Frontal-Temporal Function in Schizophrenia