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Journal Articles:

Herndandez-Diaz, S., Mittendorf, R., Smith, C.R., Hauser, W.A., Yerby, M., Holmes L.B. Association Between Topiramate and Zonisamide Use During Pregnancy and Low BirthWeight. Obstetrics & Gynecology 2014; 123(1):21-28. (click for full text)

Herndandez-Diaz, S., Smith, C.R., Shen, A., Mittendorf, R., Hauser, W.A., Yerby, M., Holmes L.B. Comparative Safety of Antiepileptic Drugs During Pregnancy. Neurology; Published online before print May 2, 2012. (click for abstract - public view, click for full text - subscription only)

Holmes L.B., Wyszynski D.F., Baldwin, E.J., Smith, C.R., Habecker, E., Glassman, L.H. Increased Frequency for Isolated Cleft Palate Among Infants Exposed to Lamotrigine During Pregnancy. Neurology 2008; 70:2152-2158. (click for full text)

Wyszynksi D.F., Nambisan M., Surve T., Alsdorf R.M., Smith C.R., Holmes L.B. Increased rate of major malformations in offspring exposed to valproate during pregnancy. Neurology 2005; 64:961-965. (click for full text)

Holmes L.B., Wyszynski D.F. North American Antiepileptic Drug Pregnancy Registry. Epilepsia 2004; 45(11):1465. (click for full text)

Holmes L.B., Wyszynski D.F., Lieberman E.S., The AED (Antiepileptic Drug) Pregnancy Registry: A 6-Year Experience. Arch Neurol. 2004; 61:673-678.(click for full text)

Abstracts & Other Texts:

Herndandez-Diaz, S., Mittendorf, R., Holmes L.B. Comparative Safety of Topiramate During Pregnancy. Birth Defects Research (Part A); 88:408 (2010). (click for abstract)

Bromfield, E. B., Dworetzky, B. A., Wyszynski, D. F., Smith, C.R., Baldwin, E. J., Holmes, L. B. Valproate Teratogenicity and Epilepsy Syndrome. Epilepsia 2008; 49(12):2122-2124. (click to view text)

Smith, C.R., Holmes, L.B. Recruitment of An Unexposed Control Group For A Pregnancy Registry. Birth Defects Research (Part A) 82:311 (2008). (click to view text)

Holmes, L.B., Smith, C.R., Herndandez-Diaz, S. Pregnancy Registries: Larger Sample Sizes Essential. Birth Defects Research (Part A) 82:307 (2008). (click to view text)

Holmes, L.B., Pregnancy Registries: The Importance of Inclusion and Exclusion Criteria. Birth Defects Research (Part A) 82:337 (2008). (click to view text)

Herndandez-Diaz, S., Smith, C.R., Wyszynski D.F., Holmes L.B. Risk of Major Malformations Among Infants Exposed to Carbamazepine During Pregnancy.
Birth Defects Research (Part A); 79:357 (2007). (click for abstract)

Unger L., Holmes L.B, Wyszynski D.F., Exclusion and Inclusion Criteria For Major Malformations: Impact on Studies of Potential Teratogens. Birth Defects Research (Part A); 76:5 (2006). (click for abstract)

Nambisan, M., Wyszynski, D.F., Holmes, L.B. Solutions to some common problems of pregnancy registries: The experience of the AED (Antiepileptic Drug) Pregnancy Registry, Birth Defects Research 2003; 67:5 (click for abstract)

A North American Registry for Epilepsy and Pregnancy, a unique public/private partnership of health surveillance. Epilepsia 1998;39:793-798. (click for abstract)

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Press Releases:

March 21, 2005 American Academy of Neurology - Press Release (Valproate) (.pdf file)

March 21, 2005 Massachusetts General Hospital - Press Release (Valproate) (.pdf file)

February 14, 2003 Press Release (Valproate)
(.pdf file)

Media Coverage:

March 22, 2005 "Anti-Seizure Drug Valproate Linked to Birth Defects"
(.pdf file)
Daily News Central

March 21, 2005 "Seizure Drug May Be Harmful During Pregnancy"
(.pdf file)


December 8, 2004 "Risk of Birth Defects Found in 2 Epilepsy Drugs" (.pdf file)
LA Times

December 7, 2004 "Antiseizure Drug Depakote Under Fire: Evidence Linking Depakote to Birth Defects is Mounting"

WebMD Medical News

May 1, 2003 "Maternal Valproate Use Tied to Major Birth Defects "
(.pdf file)
Ob.Gyn. News

March 24, 2003 "Drug Tied to Higher Risk of Birth Defects" (.pdf file)
San Diego Union-Tribune

March 14, 2003 "Seizure Prevention Drug May Lead to Birth Defects" (.pdf file)
Harvard Crimson

March 18, 2003 "Mom's valproate use increases infant's risk of major birth defects" The Medical Post

June 2001 "New Study Concludes Phenobarbital Not Safest During Pregnancy"
between us/Epilepsy Foundation

March/April 2000 "Pregnancy Has Been A Blessing"
between us/Episepsy Foundation


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